MACORATE CR 400MG TABLET belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. In addition, MACORATE CR 400MG TABLET also treats manic episodes associated with bipolar disorder. Besides this, it can also prevent migraine symptoms (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state.

MACORATE CR 400MG TABLET contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. MACORATE CR 400MG TABLET raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. MACORATE CR 400MG TABLET limits the transmission of nerve pain, thereby preventing migraine headaches.

MACORATE CR 400MG TABLET should be taken as prescribed by the doctor. You may sometimes experience nausea, upset stomach or stomach pain, tremors (shakes), sleepiness, headache, weight gain and thinning hair. Most of these side effects are temporary and will go away on their own. However, if you suffer these adverse effects on a regular basis, you should consult your doctor.

Inform your doctor if you are allergic to any components present in MACORATE CR 400MG TABLET. If you are pregnant, do not take MACORATE CR 400MG TABLET because it may cause serious congenital defects. Use effective contraception if you are of childbearing age while taking MACORATE CR 400MG TABLET. If you are breastfeeding, inform your doctor before taking MACORATE CR 400MG TABLET. As MACORATE CR 400MG TABLET causes sleepiness and dizziness, do not drive or operate machinery. Avoid drinking alcohol with MACORATE CR 400MG TABLET as it may cause dizziness and tiredness. To rule out any negative effects, keep your doctor updated about your health condition and medications.

MACORATE CR 400MG TABLET contains Valproic acid, an anticonvulsant (or anti-epileptic) medicine that reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. MACORATE CR 400MG TABLET raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. MACORATE CR 400MG TABLET limits the transmission of nerve pain, thereby preventing migraine headaches.

• Stomach pain
• Feeling or being sick
• Diarrhoea
• Dry or sore mouth or swollen gums
• Shakes (tremors) in a part of your body
• Unusual eye movements
• Feeling tired or sleepy
• Headache
• Weight gain
• Thinning hair, or changes to the colour or texture of your hair
• Irregular or delayed periods

Before taking the MACORATE CR 400MG TABLET, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby, or are breastfeeding. You should not become pregnant while you are receiving MACORATE CR 400MG TABLET. Consult your doctor immediately if you become pregnant while receiving a MACORATE CR 400MG TABLET. Alcohol should be avoided during treatment with this medicine. You must not drive or operate machinery while receiving MACORATE CR 400MG TABLET.

Drug-Drug Interactions: MACORATE CR 400MG TABLET may interact with other anti-epileptic drugs (e.g. carbamazepine), blood thinner (e.g. warfarin), pain killers (e.g. aspirin), a medicine for stomach ulcers (e.g. cimetidine), medicines to treat HIV and AIDS (e.g. ritonavir), antibiotics (e.g. erythromycin), medicines for depression or other mental health problems (e.g. venlafaxine, quetiapine), cholesterol-lowering medicines (e.g. cholestyramine), medicines to prevent malaria (e.g. mefloquine, chloroquine).

Drug-Food Interactions: Avoid alcohol consumption while taking MACORATE CR 400MG TABLET as it might cause increased dizziness and sleepiness. 

Drug-Disease Interactions: Inform your doctor if you have depression, liver disease, urea cycle disorders, suicidal tendencies, HIV disease, hereditary mitochondrial disorders, or thrombocytopenia (low platelets).

• CARBAMAZEPINE
• WARFARIN
• ASPIRIN
• CIMETIDINE
• RITONAVIR
• ERYTHROMYCIN
• VENLAFAXINE
• QUETIAPINE
• CHOLESTYRAMINE
• MEFLOQUINE
• CHLOROQUINE

• Adolescents and adults are advised to follow the Atkins diet (high fat, low carbohydrate).
• Exercising on a regular basis aids with weight maintenance and general health.
• Rest well, and get plenty of sleep.
• Avoid smoking and drinking alcohol.
• Meditation and yoga can help reduce stress, reduce pain sensitivity, and increase coping abilities.
• Have a seizure response plan in place, and make sure everyone around you knows what to do in the event of a seizure.
• Prepare your living environment; simple changes may help reduce the risk of physical damage during a seizure.
• Understand what causes seizures and try to reduce or avoid them.
• Please keep your overall health in mind, as it can aid in the reduction of seizure activity.
• Install an alarm or an emergency gadget to summon help during a seizure attack.

• Blood and urine tests may be affected by the MACORATE CR 400MG TABLET. Inform the person conducting the exams that you will be taking MACORATE CR 400MG TABLET.
• If you are of childbearing age, utilise effective contraception continuously during your treatment with MACORATE CR 400MG TABLET.
• Contact your doctor immediately if you become pregnant while taking MACORATE CR 400MG TABLET.

Epilepsy: It is a sudden rush of electricity in the brain. It is a nervous system disorder that occurs due to disturbed nerve cell activity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden electrical impulses that affect an individual's consciousness, movements, or sensations. Seizures are of two types: generalized and partial seizures. Generalized seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle cramps and spasms. More substantial seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury, or stroke.

Bipolar disorder: Bipolar disorder, also known as manic depression or bipolar disease, is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. Symptoms of manic episodes include high energy, loss of touch with reality, and reduced need for sleep. Symptoms of depressive episodes include low motivation, low energy, and loss of interest in daily life.

Migraine: Migraine is a neurological condition that is characterized by intense headaches. A migraine is usually a moderate or severe headache felt as a throbbing pain on one side of the head.