MACOX 450MG TABLET belongs to the group of medicines called macrolide antibiotics, primarily used in combination with other medicines to treat tuberculosis (TB). Tuberculosis is an infectious respiratory disease that affects the lungs but can also spread to other body parts such as the kidneys, brain, spine, and bone marrow. It is also used to treat other bacterial infections. MACOX 450MG TABLET does not work against infections caused by the virus, including cold and flu. As MACOX 450MG TABLET is an antibiotic, it does not work against infections caused by the virus, including cold and flu. The bacteria causing tuberculosis (TB) are highly contagious that spread from one person to another via tiny droplets released into the air (through coughs or sneezes).

MACOX 450MG TABLET consists of a drug called 'rifampicin' which works by inactivating a bacterial protein enzyme (RNA-polymerase) and inhibits bacterial cell death.  MACOX 450MG TABLET acts against the bacteria called Mycobacterium tuberculosis, which causes TB (tuberculosis). 

MACOX 450MG TABLET should be taken as recommended by your doctor. It should be taken 30 minutes before food or 2 hours after food on an empty stomach. In some cases, you may experience certain common side effects, such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhea, gas, and numbness or tingling sensation. Most of these side effects are mild and subside over time. However, if any of these effects persist contact your doctor immediately.

MACOX 450MG TABLET may raise liver enzymes like ALT and can cause jaundice if taken longer. Hence, a regular liver function test (LFT) is recommended while taking treatment with MACOX 450MG TABLET. Maintain a gap of one hour between MACOX 450MG TABLET and antacid medicines. MACOX 450MG TABLET is not recommended if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking MACOX 450MG TABLET as it passes into breast milk. MACOX 450MG TABLET may cause dizziness, and vision problems; hence avoid driving vehicles or operating machines that require mental concentration. Avoid alcohol consumption while taking MACOX 450MG TABLET as it could lead to increased drowsiness, dizziness, and liver damage.

MACOX 450MG TABLET contains 'Rifampicin' that treats Tuberculosis (TB) by inactivating a bacterial genetic material that allows TB bacteria to make a copy of its protein for further growth inside the host cell (human). MACOX 450MG TABLET is active against gram-positive cocci bacteria like Mycobacteria, Clostridium difficle and gram-negative bacteria like Neisseria meningitides, N. gonorrhoeae and Hemophilus influenzae. MACOX 450MG TABLET is also used as a second-line treatment in the treatment of cholestatic pruritus. It also treats leprosy, severe gram-positive bacterial infections (like osteomyelitis, endocarditis, brain abscess, meningitis and implant infections) in combinations with other antibiotics. 

• Drowsiness
• Dizziness 
• Headache 
• Weakness
• Muscle pain
• Heartburn 
• Diarrhoea 
• Gas 
• Numbness or tingling sensation 

MACOX 450MG TABLET should be avoided if you are allergic to any of its contents. Inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems on priority before starting treatment with MACOX 450MG TABLET. Avoid foods and drinks containing histamines or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while treating with MACOX 450MG TABLET as they might cause interaction. Maintain a gap of one hour between MACOX 450MG TABLET and antacid medicines.

MACOX 450MG TABLET is not recommended for pregnant women. Hence, inform your doctor if you are pregnant or planning for pregnancy. Avoid breastfeeding while using MACOX 450MG TABLET as it passes into breast milk. MACOX 450MG TABLET should be given to children only if prescribed by the paediatrician. MACOX 450MG TABLET may cause dizziness or drowsiness, so avoid driving vehicles. Avoid alcohol consumption along with MACOX 450MG TABLET as it could lead to increased drowsiness, dizziness and liver damage.

DRUG-DRUG INTERACTIONS: MACOX 450MG TABLET may have interaction with pain killers (acetaminophen, hydrocodone), anti-TB (ethambutol, pyrazinamide) and vitamins (ergocalciferol, cholecalciferol, ascorbic acid), blood thinners (warfarin), Antacids (Pantoprazole, omeprazole), Antibiotics (doxycycline, ciprofloxacin, amoxicillin), cough syrups (diphenhydramine), anti-seizure drugs  ( phenytoin, phenobarbital, Iamotrigine),  azole antifungals (itraconazole, ketoconazole, voriconazole), calcium channel blockers (diltiazem, nimodipine, verapamil).

FOOD-DRUG INTERACTIONS: Do not consume alcohol while taking MACOX 450MG TABLET as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking MACOX 450MG TABLET as they might cause interaction.

DRUG-DISEASE INTERACTION: MACOX 450MG TABLET may have interactions with colitis (inflammation in the lining of the colon),  porphyria ( blood disease), hemodialysis, liver toxicity, and kidney and liver dysfunction.

• ACETAMINOPHEN
• HYDROCODONE
• ERGOCALCIFEROL
• ASCORBIC ACID
• CHOLECALCIFEROL
• WARFARIN
• PANTOPRAZOLE
• DOXYCYCLINE
• CIPROFLOXACIN
• AMOXICILLIN
• DIPHENHYDRAMINE

• Try to take foods rich in vitamin C such as orange, kiwi, broccoli, and bell pepper which helps in improving the immune system. 
• Avoid consuming processed and fried foods.
• Warm ginger tea or warm soup can help in providing relief from cough.
• Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.
• Smoking and alcohol consumption should be avoided as it causes dizziness.
• Drinking pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.

• MACOX 450MG TABLET may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.
• MACOX 450MG TABLET may cause temporary discolouration of urine, tears, and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discoloured. Contact your doctor for further advice.
• Regular liver tests may be advised by your doctor while taking MACOX 450MG TABLET to check how your liver is functioning.
• MACOX 450MG TABLET may affect test results of some blood tests such as folate, vitamin B12, and liver function tests. Hence inform your doctor or the lab person if any such tests are advised.

Tuberculosis (TB): It is an infectious disease that affects the lungs, but it could also spread to other body parts such as the kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease that can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.