MACOX PLUS 150MG TABLET belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.

MACOX PLUS 150MG TABLET is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, MACOX PLUS 150MG TABLET kills Mycobacterium tuberculosis which causes TB (tuberculosis).

In some cases, you may experience certain common side-effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor before taking MACOX PLUS 150MG TABLET if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking MACOX PLUS 150MG TABLET as it passes into breast milk. MACOX PLUS 150MG TABLET may cause dizziness, and vision problems, so drive only if you are alert. Avoid alcohol consumption while taking MACOX PLUS 150MG TABLET as it could lead to increased drowsiness, dizziness and liver damage.

MACOX PLUS 150MG TABLET is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, MACOX PLUS 150MG TABLET kills Mycobacterium tuberculosis which causes TB (tuberculosis).

• Drowsiness
• Dizziness
• Headache
• Weakness
• Muscle pain 
• Heartburn 
• Diarrhoea
• Gas
• Numbness 

Do not take MACOX PLUS 150MG TABLET if you are allergic to any of its contents; if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting MACOX PLUS 150MG TABLET, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Consult your doctor before taking MACOX PLUS 150MG TABLET if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking MACOX PLUS 150MG TABLET as it passes into breast milk. MACOX PLUS 150MG TABLET may cause dizziness, and drowsiness, so drive only if you are alert. Avoid alcohol consumption while taking MACOX PLUS 150MG TABLET as it could lead to increased drowsiness, dizziness and liver damage.

Drug-Drug Interactions: MACOX PLUS 150MG TABLET may interact with anti-HIV (saquinavir, ritonavir), pain killer (acetaminophen, hydrocodone), anti-depressant (duloxetine, bupropion), calcium channel blocker (diltiazem), anti-TB (ethambutol, pyrazinamide), and vitamins (ergocalciferol, cholecalciferol).

Drug-Food Interactions: Do not consume alcohol while taking MACOX PLUS 150MG TABLET as it could lead to increased dizziness and liver damage. Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer while taking MACOX PLUS 150MG TABLET as they might cause interaction.

Drug-Disease Interactions: Inform your doctor if you have colitis (inflammation in the lining of the colon), peripheral neuropathy (numbness and pain in hands and feet), porphyria, haemodialysis, liver toxicity, kidney and liver dysfunction.

• SAQUINAVIR
• RITONAVIR
• ACETAMINOPHEN
• HYDROCODONE
• DULOXETINE
• BUPROPION
• DILTIAZEM
• ETHAMBUTOL
• PYRAZINAMIDE
• CHOLECALCIFEROL
• ERGOCALCIFEROL

• Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
• Foods rich in vitamin C such as kiwi, broccoli, and bell pepper helps in improving the immune system. 
• Avoid processed and fried foods.
• Warm ginger tea or warm soup can help in providing relief from cough.
• Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
• Quit smoking and avoid alcohol consumption.

• MACOX PLUS 150MG TABLET may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking MACOX PLUS 150MG TABLET.
• Your doctor may advise you to get regular liver tests while taking MACOX PLUS 150MG TABLET to check how your liver is functioning.

Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.