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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Whats That

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Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About Macox-Plus Kid Tablet

Macox-Plus Kid Tablet belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.

Macox-Plus Kid Tablet is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, Macox-Plus Kid Tablet kills Mycobacterium tuberculosis which causes TB (tuberculosis).

In some cases, you may experience certain common side-effects such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor before taking Macox-Plus Kid Tablet if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Macox-Plus Kid Tablet as it passes into breast milk. Macox-Plus Kid Tablet may cause dizziness, and vision problems, so drive only if you are alert. Avoid alcohol consumption while taking Macox-Plus Kid Tablet as it could lead to increased drowsiness, dizziness and liver damage.

Uses of Macox-Plus Kid Tablet

Tuberculosis.

Directions for Use

Take Macox-Plus Kid Tablet 30 minutes before food or 2 hours after food. Swallow Macox-Plus Kid Tablet as a whole; do not crush or chew it.

Key Benefits

Macox-Plus Kid Tablet is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, Macox-Plus Kid Tablet kills Mycobacterium tuberculosis which causes TB (tuberculosis).

Storage

Store in a cool and dry place away from sunlight
Side effects of Macox-Plus Kid Tablet

Drug Warnings

Do not take Macox-Plus Kid Tablet if you are allergic to any of its contents; if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting Macox-Plus Kid Tablet , please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Consult your doctor before taking Macox-Plus Kid Tablet if you are pregnant or planning for pregnancy. Avoid breastfeeding while taking Macox-Plus Kid Tablet as it passes into breast milk. Macox-Plus Kid Tablet may cause dizziness, and drowsiness, so drive only if you are alert. Avoid alcohol consumption while taking Macox-Plus Kid Tablet as it could lead to increased drowsiness, dizziness and liver damage.

Drug-Drug Interactions

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RifampicinSaquinavir
Critical

Drug-Drug Interactions

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RifampicinSaquinavir
Critical
How does the drug interact with Macox-Plus Kid Tablet:
Taking saquinavir with Macox-Plus Kid Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
When Indinavir is taken with Macox-Plus Kid Tablet, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Taking pirfenidone with Macox-Plus Kid Tablet can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Taking darunavir with Macox-Plus Kid Tablet can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
Taking Voriconazole with Macox-Plus Kid Tablet can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with Macox-Plus Kid Tablet, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
When ranolazine is taken with Macox-Plus Kid Tablet, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Macox-Plus Kid Tablet:
When Macox-Plus Kid Tablet is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Macox-Plus Kid Tablet is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidLomitapide
Critical
How does the drug interact with Macox-Plus Kid Tablet:
When Lomitapide is taken with Macox-Plus Kid Tablet, Macox-Plus Kid Tablet may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Macox-Plus Kid Tablet with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
How does the drug interact with Macox-Plus Kid Tablet:
When Lovastatin is taken with Macox-Plus Kid Tablet, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Macox-Plus Kid Tablet with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
RifampicinBedaquiline
Severe
How does the drug interact with Macox-Plus Kid Tablet:
Taking bedaquiline with Macox-Plus Kid Tablet can decrease the blood levels of bedaquiline, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between bedaquiline and Macox-Plus Kid Tablet, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C such as kiwi, broccoli, and bell pepper helps in improving the immune system. 
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from cough.
  • Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Side Effects of Macox-Plus Kid Tablet

  • Drowsiness
  • Dizziness
  • Headache
  • Weakness
  • Muscle pain 
  • Heartburn 
  • Diarrhoea
  • Gas
  • Numbness 

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Macox-Plus Kid Tablet is a combination of two anti-tuberculosis drugs, namely: Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, Macox-Plus Kid Tablet kills Mycobacterium tuberculosis which causes TB (tuberculosis).

Do not stop taking Macox-Plus Kid Tablet despite symptomatic relief. To treat your condition effectually, continue taking Macox-Plus Kid Tablet for as long as it has been prescribed for you.

Do not take Macox-Plus Kid Tablet along with antacids as it might decrease the effectiveness of Macox-Plus Kid Tablet . Maintain a minimum gap of 1hour between both.

Consult your doctor before taking Macox-Plus Kid Tablet with other medicines. Medicines used to treat TB such as PAS (P-amino salicylic acid) and cycloserine should be taken 8hours apart from Macox-Plus Kid Tablet .

Macox-Plus Kid Tablet contains isoniazid which might interact with foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking Macox-Plus Kid Tablet .

Macox-Plus Kid Tablet might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking Macox-Plus Kid Tablet . Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.

Macox-Plus Kid Tablet may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time even after you stop taking Macox-Plus Kid Tablet . Do not worry as it is a common side-effect of Macox-Plus Kid Tablet .

Yes, Macox-Plus Kid Tablet might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lens while taking Macox-Plus Kid Tablet .

Macox-Plus Kid Tablet may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking Macox-Plus Kid Tablet .

Yes, Macox-Plus Kid Tablet may cause liver problems, especially in people who are 35 and older. Consult your doctor if you notice symptoms such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may advise you to get regular liver tests while taking Macox-Plus Kid Tablet to check how your liver is functioning.

Drug-Drug Interactions Checker List

  • SAQUINAVIR
  • RITONAVIR
  • ACETAMINOPHEN
  • HYDROCODONE
  • DULOXETINE
  • BUPROPION
  • DILTIAZEM
  • ETHAMBUTOL
  • PYRAZINAMIDE
  • CHOLECALCIFEROL
  • ERGOCALCIFEROL

Special Advise

  • Macox-Plus Kid Tablet may affect test results of some blood tests such as tests for folate, vitamin B12, and liver function. Inform the person doing the tests that you are taking Macox-Plus Kid Tablet .
  • Your doctor may advise you to get regular liver tests while taking Macox-Plus Kid Tablet to check how your liver is functioning.

Disease/Condition Glossary

Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine, and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or with normal breathing, unexplained fatigue, fever, night sweats, loss of appetite and weight. People who smoke or consume alcohol, people diagnosed with HIV, and immune system problems are more likely at risk of developing active TB.

Have a query?

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Alcohol

Safe if prescribed

Avoid alcohol consumption while taking Macox-Plus Kid Tablet as it could lead to increased drowsiness, dizziness and liver damage.

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Pregnancy

Consult your doctor

Please consult your doctor if you are pregnant, your doctor will prescribe Macox-Plus Kid Tablet only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Macox-Plus Kid Tablet passes into breast milk. Do not breastfeed while taking Macox-Plus Kid Tablet .

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Driving

Safe if prescribed

Macox-Plus Kid Tablet may cause dizziness, drowsiness, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Consult your doctor

Dose adjustment may be needed. Please consult your doctor before taking Macox-Plus Kid Tablet if you have liver impairment/liver disease.

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Kidney

Consult your doctor

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Macox-Plus Kid Tablet .

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Children

Safe if prescribed

Please consult your doctor. Your doctor may suggest suitable dose and dosage form based on your child's age, body weight and medical condition. Kid tablets could be used in children if prescribed by the doctor.

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