Manflam MR 100mg/500mg/250mg Tablet is a combination drug that belongs to NSAIDs (non-steroidal anti-inflammatory drugs) or pain killers primarily used for pain relief and muscle relaxation. Muscle pain (myalgia) is widespread and generally refers to uncomfortable sensations in the muscles which can be due to illness, injury or excessive exercise. It can be continuous or can also occur at intervals.

Manflam MR 100mg/500mg/250mg Tablet contains three medicines, namely: Aceclofenac (pain killer), Paracetamol (fever reducer/mild pain reliever) and Chlorzoxazone (muscle relaxant). Aceclofenac and Paracetamol together work by blocking the effect of a natural chemical messenger called cyclo-oxygenase (COX) enzymes that make another chemical (prostaglandins). These prostaglandins are produced at sites of damage or injury and cause inflammation and pain. On the other hand, Chlorzoxazone is a muscle relaxant that works by centrally acting on the spinal cord by depressing reflexes, thereby relieving pain and stiffness caused due to muscle strains and sprains.

Manflam MR 100mg/500mg/250mg Tablet can be taken with or without food as advised by your doctor for the best results. Do not stop taking Manflam MR 100mg/500mg/250mg Tablet even if you feel better to avoid any unpleasant side effects. Common side effects of Manflam MR 100mg/500mg/250mg Tablet include nausea, vomiting, heartburn, stomach pain, diarrhoea, and loss of appetite. If any of these side effects get worse or do not subside, please visit your doctor immediately.

Manflam MR 100mg/500mg/250mg Tablet should not be taken if you have any serious medical condition, severe kidney or liver disease, are planning to become pregnant or are pregnant. Also, consumption of alcohol should be avoided while taking Manflam MR 100mg/500mg/250mg Tablet as it may increase the drowsiness and dizziness. So, driving a motor vehicle and operating heavy machinery should be avoided. Excess of paracetamol intake can cause liver damage so; its dose should not exceed more than 4 gm per day.

Aceclofenac and Paracetamol together work by blocking the effect of a natural chemical messenger called cyclo-oxygenase (COX) enzymes that make another chemical (prostaglandins). These prostaglandins are produced at sites of damage or injury and cause inflammation and pain. On the other hand, Chlorzoxazone is a muscle relaxant that works by centrally acting on the spinal cord by depressing reflexes, thereby relieving pain and stiffness caused due to muscle strains and sprains.

• Nausea
• Vomiting
• Heartburn
• Stomach pain
• Diarrhoea
• Loss of appetite
• Tiredness
• Sleepiness

Manflam MR 100mg/500mg/250mg Tablet should not be taken if you have any serious medical condition, severe kidney or liver disease, are planning to become pregnant or are pregnant. Also, consumption of alcohol should be avoided while taking Manflam MR 100mg/500mg/250mg Tablet as it may increase the drowsiness and dizziness. So, driving a motor vehicle and operating heavy machinery should be avoided. Excess of paracetamol intake can cause liver damage so; its dose should not exceed more than 4 gm per day.

Drug-Drug Interactions: Manflam MR 100mg/500mg/250mg Tablet interacts with sleeping pills (alprazolam, escitalopram, zolpidem), pain killers (tramadol, oxycodone, hydrocodone), antiepileptics or medicines for fits (gabapentin, topiramate, pregabalin), diuretics or water pills (fluoxetine), an antidepressant (duloxetine), antiallergic (diphenhydramine, cetirizine), muscle relaxant and antispasmodic (baclofen).

Drug-Food Interactions: St. John's wort (a herbal supplement) used as an antidepressant can interact with Manflam MR 100mg/500mg/250mg Tablet and cause dizziness, so its usage should be avoided with Manflam MR 100mg/500mg/250mg Tablet.

Drug-Disease Interactions: People with alcoholism, liver disease, kidney disease, stomach ulcer/bleeding, and intestinal ulcer/bleeding should avoid using Manflam MR 100mg/500mg/250mg Tablet.

• ALPRAZOLAM
• ESCITALOPRAM
• ZOLPIDEM
• TRAMADOL
• OXYCODONE
• GABAPENTIN
• TOPIRAMATE
• PREGABALIN
• FLUOXETINE
• DULOXETINE
• DIPHENHYDRAMINE
• CETIRIZINE
• BACLOFEN

• Try to increase the consumption of calcium and vitamin D, as recommended as part of a healthy bone diet.
• Omega 3 fatty acid oils enriched food should include in your daily meal for keeping joints healthy.
• Connective tissues are the “cellular glue” that connects and support vital organs in the body. This connective tissue is comprised of proteins like collagen and elastin. So the requirement of proteins are required for keeping your muscle healthy, so intake of high protein diets like fish (salmon, sardines, and tuna), chicken, and eggs for non-vegetarian. While legumes, nuts, seed and dairy items (milk, yoghurt, cheese) for a vegetarian person is recommended. 
• Magnesium, Vitamin K and Zinc enriched foods can help in keeping your bones and muscle healthy so its intake should be enhanced in your daily diet plan. 
• Physical activities like Tai chi, Yoga, swimming and walking have shown improvement in managing muscle pain. 
• Do not sit for a longer duration. Try to take a gap of 10 minutes by brisk walking or stretching.

Musculoskeletal pain: It is a pain of bones, muscles, the tissues connecting to muscle-muscle and bone-muscle (cartilage, tendon) and nerves which can be felt just in one area of the body, like low back pain. This type of pain can be felt throughout the body if widespread as in the case of fibromyalgia. The musculoskeletal pain can range from mild/moderate to severe enough, which is sufficient to interfere with your daily routine. It can short-lived (acute) as well as can continue for more than 3-6 months (chronic). The most common musculoskeletal pain includes muscle pain (myalgia) from an injury, spasm, infection, or cramp. Loss of blood flow to the muscle can be one of the cause for muscle pain and inflammation. Joint pain due to rheumatoid arthritis (immune disorder) and osteoarthritis can be another contributing factor in causing the pain. Another pain-inducing factor can be nerve compression pain due to high pressure on the nerves.