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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
Non returnable*
COD available

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Whats That

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Composition :

VALPROIC ACID-250MG

Manufacturer/Marketer :

Matias Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Manigrain Er 250 Tablet 10's

Manigrain Er 250 Tablet 10's belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. In addition, Manigrain Er 250 Tablet 10's also treats manic episodes associated with bipolar disorder. Besides this, it can also prevent migraine symptoms (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state.

Manigrain Er 250 Tablet 10's contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Manigrain Er 250 Tablet 10's raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches.

Manigrain Er 250 Tablet 10's should be taken as prescribed by the doctor. You may sometimes experience nausea, upset stomach or stomach pain, tremors (shakes), sleepiness, headache, weight gain and thinning hair. Most of these side effects are temporary and will go away on their own. However, if you suffer these adverse effects on a regular basis, you should consult your doctor.

Inform your doctor if you are allergic to any components present in Manigrain Er 250 Tablet 10's. If you are pregnant, do not take Manigrain Er 250 Tablet 10's because it may cause serious congenital defects. Use effective contraception if you are of childbearing age while taking Manigrain Er 250 Tablet 10's. If you are breastfeeding, inform your doctor before taking Manigrain Er 250 Tablet 10's. As Manigrain Er 250 Tablet 10's causes sleepiness and dizziness, do not drive or operate machinery. Avoid drinking alcohol with Manigrain Er 250 Tablet 10's as it may cause dizziness and tiredness. To rule out any negative effects, keep your doctor updated about your health condition and medications.

Uses of Manigrain Er 250 Tablet 10's

Epilepsy (fits), Bipolar disorder, Migraine

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Oral Suspension/syrup: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Manigrain Er 250 Tablet 10's contains Valproic acid, an anticonvulsant (or anti-epileptic) medicine that reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Manigrain Er 250 Tablet 10's raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches.

Storage

Store in a cool and dry place away from sunlight
Side effects of Manigrain Er 250 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drug Warnings

Before taking the Manigrain Er 250 Tablet 10's, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby, or are breastfeeding. You should not become pregnant while you are receiving Manigrain Er 250 Tablet 10's. Consult your doctor immediately if you become pregnant while receiving a Manigrain Er 250 Tablet 10's. Alcohol should be avoided during treatment with this medicine. You must not drive or operate machinery while receiving Manigrain Er 250 Tablet 10's.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
DivalproexErtapenem
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Glycerol phenylbutyrate and Manigrain Er 250 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Manigrain Er 250 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexErtapenem
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Ertapenem with Manigrain Er 250 Tablet may reduce the blood levels of Manigrain Er 250 Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Manigrain Er 250 Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexMeropenem
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and Meropenem can reduce the blood levels of Manigrain Er 250 Tablet sodium.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexLeflunomide
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Manigrain Er 250 Tablet and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DivalproexMipomersen
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexBuprenorphine
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of buprenorphine with Manigrain Er 250 Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Manigrain Er 250 Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexBexarotene
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Esketamine and Manigrain Er 250 Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Manigrain Er 250 Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexKetamine
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and Ketamine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet and Ketamine can lead to an interaction, it can be taken if advised by your doctor. If you have any symptoms such as dizziness, drowsiness, shortness of breath, or impairment in thinking and motor coordination, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Sodium phenylbutyrate and Manigrain Er 250 Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Adolescents and adults are advised to follow the Atkins diet (high fat, low carbohydrate).
  • Exercising on a regular basis aids with weight maintenance and general health.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and drinking alcohol.
  • Meditation and yoga can help reduce stress, reduce pain sensitivity, and increase coping abilities.
  • Have a seizure response plan in place, and make sure everyone around you knows what to do in the event of a seizure.
  • Prepare your living environment; simple changes may help reduce the risk of physical damage during a seizure.
  • Understand what causes seizures and try to reduce or avoid them.
  • Please keep your overall health in mind, as it can aid in the reduction of seizure activity.
  • Install an alarm or an emergency gadget to summon help during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

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Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Manigrain Er 250 Tablet 10's decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.

Manigrain Er 250 Tablet 10's helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.

Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

Manigrain Er 250 Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with Manigrain Er 250 Tablet 10's. Avoid getting pregnant while taking Manigrain Er 250 Tablet 10's as it could lead to serious birth defects. Do not stop taking Manigrain Er 250 Tablet 10's and consult your doctor immediately if you become pregnant.

Manigrain Er 250 Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Drug-Drug Interactions Checker List

  • CARBAMAZEPINE
  • WARFARIN
  • ASPIRIN
  • CIMETIDINE
  • RITONAVIR
  • ERYTHROMYCIN
  • VENLAFAXINE
  • QUETIAPINE
  • CHOLESTYRAMINE
  • MEFLOQUINE
  • CHLOROQUINE

Special Advise

  • Blood and urine tests may be affected by the Manigrain Er 250 Tablet 10's. Inform the person conducting the exams that you will be taking Manigrain Er 250 Tablet 10's.
  • If you are of childbearing age, utilise effective contraception continuously during your treatment with Manigrain Er 250 Tablet 10's.
  • Contact your doctor immediately if you become pregnant while taking Manigrain Er 250 Tablet 10's.

Disease/Condition Glossary

Epilepsy: It is a sudden rush of electricity in the brain. It is a nervous system disorder that occurs due to disturbed nerve cell activity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures. In patients with seizures, the typical brain electrical pattern is disrupted by sudden electrical impulses that affect an individual's consciousness, movements, or sensations. Seizures are of two types: generalized and partial seizures. Generalized seizures affect the entire brain, whereas partial seizures affect only a part of the brain. Seizures can cause uncontrollable muscle cramps and spasms. More substantial seizures may cause people to become confused or unconscious. Possible causes include high fever, trauma, genetic disorder, brain injury, or stroke.

Bipolar disorder: Bipolar disorder, also known as manic depression or bipolar disease, is a mental health disorder associated with episodes of mood swings ranging from manic highs to depressive lows. Symptoms of manic episodes include high energy, loss of touch with reality, and reduced need for sleep. Symptoms of depressive episodes include low motivation, low energy, and loss of interest in daily life.

Migraine: Migraine is a neurological condition that is characterized by intense headaches. A migraine is usually a moderate or severe headache felt as a throbbing pain on one side of the head.

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