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  3. Mantedanib-100 Softgel Cap 10'S

Mantedanib-100 Softgel Cap 10'S, Pack of 10 CAPSULES
Mantedanib-100 Softgel Cap 10'S, Pack of 10 CAPSULES
Mantedanib-100 Softgel Cap 10'S, Pack of 10 CAPSULES
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sureshvarma D , MPharma
Non returnable*
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Whats That

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Composition :

NINTEDANIB-100MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Mantedanib-100 Softgel Cap

Mantedanib-100 Softgel Cap belongs to the category of 'anti-fibrotic medicine', and it is primarily used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, due to which it gets difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.

Mantedanib-100 Softgel Cap contains 'Nintedanib', which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Mantedanib-100 Softgel Cap helps in slowing down the progress of idiopathic pulmonary fibrosis.

Always use this medicine as your doctor has told you or per the package leaflet. You must keep to your doctor's instructions to get the maximum benefit. In some cases, you may experience common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking Mantedanib-100 Softgel Cap if you are pregnant or breastfeeding. Mantedanib-100 Softgel Cap may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Mantedanib-100 Softgel Cap as it could lead to increased dizziness. Mantedanib-100 Softgel Cap is not recommended for children below 18 years as safety and effectiveness have not been established. Mantedanib-100 Softgel Cap is listed as pregnancy category D. Because Mantedanib-100 Softgel Cap can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Mantedanib-100 Softgel Cap . Consult your doctor if you are breastfeeding; your doctor will decide whether the Mantedanib-100 Softgel Cap can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Mantedanib-100 Softgel Cap

Idiopathic pulmonary fibrosis

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Mantedanib-100 Softgel Cap is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. Mantedanib-100 Softgel Cap can help effectively slow the rate of lung function decline by 50%. Mantedanib-100 Softgel Cap helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Mantedanib-100 Softgel Cap helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Mantedanib-100 Softgel Cap
  • Do not scratch the affected region to avoid discomfort and infection.
  • Avoid spicy and fatty foods and caffeine and alcohol as they can worsen diarrhoea and irritate the skin.
  • Frequently wash your hands to avoid infection.
  • Clean the skin with fragrance-free, soft wipes to reduce inflammation.
  • Let your doctor know if the rash is severe, widespread, or painful.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To minimize pain and swelling, apply an ice pack or cold compress wrapped in a cloth as soon as there is bleeding or bruises.
  • Use a warm compress 48 hours later to promote blood flow and hasten the healing process.
  • Rest and limit activity to prevent further injury.
  • Elevate the affected area above the level of your heart to reduce blood flow.
  • To treat discomfort, your doctor may offer over-the-counter pain medicines.
  • Inform your doctor if you develop large bruises without injury or experience frequent bruising, as this may indicate an underlying condition.
  • Follow a low-fiber, soft food diet with easily digestible liquids and pureed foods.
  • Begin with clear liquids like water, broth, and electrolyte drinks.
  • Progress to soft foods like mashed potatoes, applesauce, plain yogurt, scrambled eggs, and well-cooked rice.
  • Avoid high-fiber foods, raw vegetables, tough meats, spicy foods, and irritants to the digestive tract.
  • Eat smaller, frequent meals to reduce digestive strain.
  • Stay hydrated with plenty of fluids, avoiding sugary drinks.
  • Chew food thoroughly to aid digestion.
  • Avoid strenuous activities and rest when needed.
  • Before altering your diet, seek guidance from your healthcare provider.
  • Always follow your doctor's instructions on dietary restrictions and medical supervision.

Drug Warnings

Do not use Mantedanib-100 Softgel Cap if you are allergic to any components present in Mantedanib-100 Softgel Cap . Mantedanib-100 Softgel Cap is listed as pregnancy category D; because Mantedanib-100 Softgel Cap can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Mantedanib-100 Softgel Cap . Consult your doctor if you are breastfeeding; your doctor will decide whether the Mantedanib-100 Softgel Cap can be taken by breastfeeding mothers or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. Mantedanib-100 Softgel Cap may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Mantedanib-100 Softgel Cap as it could lead to increased dizziness. Mantedanib-100 Softgel Cap is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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NintedanibCarbamazepine
Severe
NintedanibTipranavir
Severe

Drug-Drug Interactions

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NintedanibCarbamazepine
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap with Carbamazepine can reduce the levels and effects of Mantedanib-100 Softgel Cap.

How to manage the interaction:
Although taking carbamazepine and Mantedanib-100 Softgel Cap together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
NintedanibTipranavir
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap and Tipranavir can reduce the blood levels of Mantedanib-100 Softgel Cap.

How to manage the interaction:
There may be a possibility of interaction between Mantedanib-100 Softgel Cap and Tipranavir, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without first consulting your doctor.
NintedanibRifampicin
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap with Rifampicin can decrease the blood levels of Mantedanib-100 Softgel Cap, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Mantedanib-100 Softgel Cap and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
NintedanibLomitapide
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Co-administration of Lomitapide and Mantedanib-100 Softgel Cap can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Mantedanib-100 Softgel Cap can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NintedanibTeriflunomide
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Teriflunomide and Mantedanib-100 Softgel Cap can increase the risk of liver problems.

How to manage the interaction:
Coadministration of Teriflunomide and Mantedanib-100 Softgel Cap can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, loss of appetite, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately.
NintedanibPhenytoin
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Phenytoin and Mantedanib-100 Softgel Cap may decrease the blood levels of Mantedanib-100 Softgel Cap, which may reduce Mantedanib-100 Softgel Cap's effectiveness.

How to manage the interaction:
Although taking Phenytoin and Mantedanib-100 Softgel Cap together can result in an interaction, it can be taken when your doctor has prescribed it. Contact a doctor if your symptoms do not improve. Do not stop taking any drugs without consulting a doctor.
NintedanibFosphenytoin
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap with Fosphenytoin can reduce the levels of Mantedanib-100 Softgel Cap. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Mantedanib-100 Softgel Cap and Fosphenytoin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
NintedanibRifapentine
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap and Rifapentine can reduce the blood levels of Mantedanib-100 Softgel Cap.

How to manage the interaction:
There may be a possibility of interaction between Mantedanib-100 Softgel Cap and Rifapentine, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.
NintedanibPrimidone
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap and primidone can reduce the blood levels of Mantedanib-100 Softgel Cap.

How to manage the interaction:
Although there is an interaction between Mantedanib-100 Softgel Cap and primidone, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibPhenobarbital
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Taking Phenobarbital and Mantedanib-100 Softgel Cap can drastically lower Mantedanib-100 Softgel Cap levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Mantedanib-100 Softgel Cap can lead to interaction, they can be taken if recommended by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Mantedanib-100 Softgel Cap Substitute

Substitutes safety advice

Product Substitutes

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:40 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Mantedanib-100 Softgel Cap helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.

Avoid smoking before starting the treatment while taking Mantedanib-100 Softgel Cap as smoking might alter the effectiveness of Mantedanib-100 Softgel Cap .

Mantedanib-100 Softgel Cap should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Mantedanib-100 Softgel Cap until your doctor asks you to stop it.

If you have any surgery, including dental surgery, please inform your doctor if you are taking Mantedanib-100 Softgel Cap as your doctor might stop Mantedanib-100 Softgel Cap before undergoing surgery.

In elderly patients, the risk of side effects is more if you are taking Mantedanib-100 Softgel Cap . For the patients who are elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.

Idiopathic pulmonary fibrosis is treated with Mantedanib-100 Softgel Cap (IPF; scarring of the lungs with an unknown cause). It's also used to treat fibrosing interstitial lung disorders.

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ERYTHROMYCIN
  • CYCLOSPORINE
  • RIFAMPICIN
  • CARBAMAZEPINE
  • PHENYTOIN

Special Advise

  • Regular blood tests and occasional tests of your bone marrow will be carried out to check whether the treatment is working. If it does work, it will usually be taken for life.

Disease/Condition Glossary

Idiopathic pulmonary fibrosis (IPF): Idiopathic pulmonary fibrosis belongs to a group of interstitial lung diseases. It is an irreversible chronic disease marked by a progressive decline in lung function. The tissues in the lungs become inflamed and scarred over time, due to which it gets difficult to breathe properly. The scar tissue, known as fibrosis, becomes thick /stiff over time, making it hard for the lungs to work efficiently. This causes decreased lung function, which leads to increased breathlessness and coughing. Breathing difficulties can lead to other medical problems. Symptoms of IPF are shortness of breath, persistent dry cough, loss of appetite, weight loss, and rounded and widened tips of the fingers and toes.

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