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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Synonym :

EPIRUBICIN HYDROCHLORIDE

Composition :

EPIRUBICIN-50MG

Manufacturer/Marketer :

Amps Biotech Biotech Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Mapsepicin-50 Injection 1's

Mapsepicin-50 Injection 1's is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer in people who have had tumor removal surgery. Mapsepicin-50 Injection 1's is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast).

Mapsepicin-50 Injection 1's contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Mapsepicin-50 Injection 1's may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Mapsepicin-50 Injection 1's. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Mapsepicin-50 Injection 1's should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines, and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (eg, Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. Mapsepicin-50 Injection 1's is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Mapsepicin-50 Injection 1's is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF.

Uses of Mapsepicin-50 Injection 1's

Breast Cancer

Directions for Use

A trained healthcare professional will administer Mapsepicin-50 Injection 1's. Hence, do not self-administer.

Medicinal Benefits

Mapsepicin-50 Injection 1's contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. It is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mapsepicin-50 Injection 1's

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection
  • Red discoloration of urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Weight gain
  • Pale skin

Drug Warnings

Mapsepicin-50 Injection 1's should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (e.g., Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. Mapsepicin-50 Injection 1's is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Mapsepicin-50 Injection 1's is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF. Do not stop receiving Mapsepicin-50 Injection 1's without a doctor’s advice, as it can cause serious health conditions. Mapsepicin-50 Injection 1's is known to cause severe life-threatening haematological reactions, tissue necrosis, cardiomyopathy, secondary acute myelogenous leukaemia, and severe myelosuppression in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
EpirubicinEtanercept
Severe

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
How does the drug interact with Mapsepicin-50 Injection:
Using ziprasidone together with Mapsepicin-50 Injection can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Ziprasidone with Mapsepicin-50 Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinEtanercept
Severe
How does the drug interact with Mapsepicin-50 Injection:
When Etanercept is used with Mapsepicin-50 Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Mapsepicin-50 Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EpirubicinGatifloxacin
Severe
How does the drug interact with Mapsepicin-50 Injection:
Taking Mapsepicin-50 Injection with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Mapsepicin-50 Injection with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EpirubicinBaricitinib
Severe
How does the drug interact with Mapsepicin-50 Injection:
Coadministration of baricitinib and Mapsepicin-50 Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Mapsepicin-50 Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
EpirubicinMifepristone
Severe
How does the drug interact with Mapsepicin-50 Injection:
Co-administration of Mapsepicin-50 Injection with mifepristone can increase the risk of irregular heart rhythms. Prolonged treatment with Mifepristone may result in low potassium levels.

How to manage the interaction:
Taking Mapsepicin-50 Injection with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
EpirubicinTofacitinib
Severe
How does the drug interact with Mapsepicin-50 Injection:
Taking Tofacitinib with Mapsepicin-50 Injection may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Mapsepicin-50 Injection with Tofacitinib can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - make sure to call your doctor right away. Do not discontinue any medications without first consulting your doctor.
EpirubicinNilotinib
Severe
How does the drug interact with Mapsepicin-50 Injection:
Coadministration of Mapsepicin-50 Injection and nilotinib can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Mapsepicin-50 Injection and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
EpirubicinDisopyramide
Severe
How does the drug interact with Mapsepicin-50 Injection:
The combined use of Efavirenz and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Efavirenz and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EpirubicinHaloperidol
Severe
How does the drug interact with Mapsepicin-50 Injection:
Co-administration of Mapsepicin-50 Injection and Haloperidol can affect the rhythm of the heart.

How to manage the interaction:
Co-administration of Mapsepicin-50 Injection and Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EpirubicinMoxifloxacin
Severe
How does the drug interact with Mapsepicin-50 Injection:
Using Moxifloxacin together with Mapsepicin-50 Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Mapsepicin-50 Injection together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heart rhythm, vomiting, dizziness, difficulty breathing, or irregular heartbeat call a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to eat more healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.
  • Doing meditation and yoga for some time is very effective in helping cancer patients maintain a healthy attitude and body.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Mapsepicin-50 Injection 1's Substitute

Substitutes safety advice
  • ALRUBICIN 50MG INJECTION 25ML

    by Others

    46.80per tablet
  • Anthracin 50mg Injection

    by Others

    54.80per tablet
  • Epricin 50mg Injection

    by Others

    1875.00per tablet
  • Epialfa 50mg Injection

    by Others

    1350.00per tablet
  • Epicin RD 50mg Injection

    by Others

    2241.00per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Mapsepicin-50 Injection 1's contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Mapsepicin-50 Injection 1's can disrupt a woman's natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with Mapsepicin-50 Injection 1's.

Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • DOXORUBICIN
  • ABIRATERONE
  • TAMOXIFEN
  • LETROZOLE
  • PACLITAXEL
  • DOCETAXEL
  • CIMETIDINE
  • CILNIDIPINE
  • NIFEDIPINE

Special Advise

  • Avoid having intercourse while on treatment with Mapsepicin-50 Injection 1's.
  • Regular monitoring of complete blood count  (CBC) and liver function (LFT) is important while receiving Mapsepicin-50 Injection 1's.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

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