MEFRAN SPAS TABLET is a combination medicine used to treat abdominal pain, dysmenorrhea (period pain), and colicky pain. Abdominal (tummy) pain occurs between the chest and pelvic region (below the belly button and leg). Menstrual cramps, also known as dysmenorrhea, are characterised by cramps and pain during menstruation. Colic is a form of pain that starts and stops abruptly.

MEFRAN SPAS TABLET is a combination of two drugs: Dicyclomine (anti-spasmodic) and Mefenamic acid (NSAID). Dicyclomine works by relieving contractions associated with the smooth muscles of the abdomen. Mefenamic acid works by blocking the effect of chemical messengers called prostaglandins. This helps reduces mild to moderate pain and inflammation at the injured or damaged site. Together, MEFRAN SPAS TABLET helps in relieving pain.

You are advised to take MEFRAN SPAS TABLET for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, MEFRAN SPAS TABLET may cause common side effects such as nausea, vomiting, diarrhoea, dry mouth, and weakness. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. MEFRAN SPAS TABLET may cause dizziness and drowsiness, so drive with caution. MEFRAN SPAS TABLET is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol with MEFRAN SPAS TABLET as it could lead to increased drowsiness and dizziness, it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

MEFRAN SPAS TABLET is a combination of two drugs, namely: Dicyclomine (anti-spasmodic) and Mefenamic acid (NSAID). MEFRAN SPAS TABLET is used to treat abdominal pain, dysmenorrhea (period pain), and colicky pain. Dicyclomine works by relieving contractions associated with the smooth muscles of the abdomen. Mefenamic acid works by blocking the effect of chemical messengers called prostaglandins. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Together, MEFRAN SPAS TABLET helps in relieving pain.

• Nausea
• Vomiting
• Diarrhoea
• Dizziness
• Headache
• Dry mouth
• Weakness
• Nervousness
• Loss of appetite

Do not take MEFRAN SPAS TABLET if you are allergic to any of its contents, if you have severe heart failure, or have suffered bleeding problems such as bleeding from the stomach or bowels while taking any painkillers. Inform your doctor if you have/had asthma, glaucoma, myasthenia gravis, high blood pressure, inflammatory bowel disease, paralytic ileus, intestinal atony, heart, kidney, or liver problems. Consult your doctor if you are pregnant or breastfeeding. MEFRAN SPAS TABLET may cause dizziness and drowsiness, so drive only if you are alert. MEFRAN SPAS TABLET should not be given to children as safety has not been established. Avoid consuming alcohol with MEFRAN SPAS TABLET as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Stop taking MEFRAN SPAS TABLET and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with MEFRAN SPAS TABLET unless prescribed. 

Drug-Drug Interactions: MEFRAN SPAS TABLET may interact with pain killers (aspirin), diuretics (furosemide), anti-psychotics (lithium, quinidine, phenothiazine), anti-rheumatoid (methotrexate), blood thinners (warfarin), cardiac glycoside (digoxin), anti-diabetic (glibenclamide, gliclazide, glimepiride), antibiotic (gentamycin, tobramycin, amikacin, cyclosporine), anti-platelet (clopidogrel), steroid (mifepristone), immunosuppressant (tacrolimus), anti-HIV (zidovudine), and anti-emetic medications (metoclopramide).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have peptic ulcers, bleeding disorders, asthma, glaucoma, myasthenia gravis, high blood pressure, inflammatory bowel disease, paralytic ileus, intestinal atony, heart, kidney, or liver problems.

• ASPIRIN
• FUROSEMIDE
• LITHIUM
• QUINIDINE
• PHENOTHIAZINE
• METHOTREXATE
• WARFARIN
• CLOPIDOGREL
• DIGOXIN
• GLIMEPIRIDE
• GLICLAZIDE
• GLIBENCLAMIDE
• GENTAMICIN
• TOBRAMYCIN
• AMIKACIN
• CYCLOSPORINE
• MIFEPRESTONE
• TACROLIMUS
• ZIDOVUDINE
• METOCLOPRAMIDE

• Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching.
• Massages can also be helpful.
• Avoid freezing and hot temperatures.
• Avoid wearing tight-fitting clothes, instead, wear loose garments.
• Rest well, and get plenty of sleep.
• To avoid developing pressure sores, change your position every two hours.
• Hot or cold therapy can help treat muscle spasms. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.
• Stay hydrated, drink plenty of water.

• MEFRAN SPAS TABLET may prolong prothrombin time (blood test to measure blood clotting time). Therefore, frequent monitoring of prothrombin time is advised while taking MEFRAN SPAS TABLET.
• MEFRAN SPAS TABLET may cause a false-positive reaction for urinary bile test. Inform the person doing the test that you are taking MEFRAN SPAS TABLET.

Abdominal pain and cramps: Abdominal pain occurs between the chest and pelvic region, generally known as stomach or tummy pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. The common causes of abdominal pain include inflammation, infections, intestinal disorders, and obstruction/blockage.

Dysmenorrhea: Menstrual cramps, also known as dysmenorrhea, is characterised by cramps and pain during menstruation due to heavy flow. Pain, cramps, and discomfort during periods are normal. However, excessive pain during periods is not normal and requires medication. Menstrual cramps cause throbbing, aching pain in the lower belly that occurs before or during the periods.