MEGATRUM OINTMENT

MEGATRUM OINTMENT belongs to the class of dermatological preparation called 'antibiotics' combined with 'antiseptic' primarily used to treat the skin's burns and wounds. It also helps to treat wound infections after surgery. MEGATRUM OINTMENT is abroad spectrum antibiotics which help in early wound healing. MEGATRUM OINTMENT also prevents skin infection spread by harmful bacteria due to cuts, wounds and burns. 

MEGATRUM OINTMENT contains a combination of two medicines: Povidone-iodine and Metronidazole. Povidone Iodine can easily penetrate microorganisms and oxidise essential natural substances, leading to cell death. Metronidazole is an antibiotic which kills bacteria and other harmful organisms by damaging their DNA. MEGATRUM OINTMENT has broad-spectrum activity and is effective against many microbes, including gram-positive and gram-negative bacteria, fungi and protozoa. MEGATRUM OINTMENT is used in degerming (physical removal of microbes), stasis ulcers (wound on the leg or ankle due to damaged veins), decubitus ulcers (bed sores) and the umbilical area.

MEGATRUM OINTMENT is for external use only. Your doctor will decide the dose depending on the medical condition. Contact of MEGATRUM OINTMENT with eye should be avoided; if you accidentally touch eyes while applying MEGATRUM OINTMENT, please wash it immediately. MEGATRUM OINTMENT has common side effects, as every medicine does. These include local swelling, itchiness, redness, small blisters and irritation at the application site. These side effects gradually resolve during the treatment and do not require medical attention.

Brief your medical history to the doctor if you are allergic to MEGATRUM OINTMENT. Please consult your doctor if you are pregnant or planning to conceive before using MEGATRUM OINTMENT since it can affect the unborn baby. Using MEGATRUM OINTMENT during breastfeeding may increase the iodine levels in the breastmilk, which can cause hypothyroidism in breastfed infants. Let your doctor know if you have an overactive thyroid gland (hyperthyroidism), thyroid disease, or liver and kidney problems. Please tell your doctor if you are undergoing lithium therapy or radioactive iodine treatment. MEGATRUM OINTMENT should not be used before or after radioiodine scintigraphy or radioiodine treatment of thyroid carcinoma.

MEGATRUM OINTMENT is a combination medication containing Povidone-iodine (antiseptic) and Metronidazole (antibiotic) primarily used to treat and prevent skin infections in minor burns, lacerations (deep cut in the skin), cuts, and abrasions (the first layer of skin is scraped off). It is also used to treat postoperative wound infections. Povidone-iodine is an antiseptic applied on skin infected or likely to get infected. It slowly releases iodine which kills or prevents the growth of these microorganisms. Metronidazole, being bactericidal in nature, kills the bacteria by damaging its genetic material (DNA) and preventing its growth, hence relieving the symptoms. Together, MEGATRUM OINTMENT prevents the growth of the microorganisms and promotes early wound healing.

• Local swelling
• Dry skin
• Irritation
• Redness
• Itchiness

Do not use MEGATRUM OINTMENT if you are allergic to povidone-iodine and metronidazole. Use MEGATRUM OINTMENT for the full recommended length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of another disease resistant to antibiotics. Avoid contact with your eyes, nose, or mouth. Rinse it off with water if you accidentally get the cream in these areas. Let your doctor know if you have an overactive thyroid gland (hyperthyroidism), any other thyroid diseases, or liver and kidney problems since the usage of MEGATRUM OINTMENT can cause iodine absorption into the body. This iodine absorption may lead to a rapid heartbeat (tachycardia) and restlessness, imbalance of electrolytes, abnormal blood concentration (osmolarity), and abnormal kidney function (renal impairment). Please tell your doctor if you are undergoing lithium therapy or radioactive iodine treatment. MEGATRUM OINTMENT should not be used before or after radioiodine scintigraphy or radioiodine treatment of thyroid carcinoma. Please consult your doctor if you are pregnant or planning to conceive before using the MEGATRUM OINTMENT since it can affect the unborn baby. Using MEGATRUM OINTMENT during breastfeeding may increase the iodine levels in the breastmilk, which can cause hypothyroidism in breastfed infants.

Drug-Drug Interactions: MEGATRUM OINTMENT may interact with other antiseptics and products containing enzymatic components, alkali, mercury, silver, hydrogen peroxide, tannic acid, and taurolidine, psychiatric medication (lithium), antiviral (amprenavir, ritonavir, tipranavir), a medicine used to treat chronic alcoholism (disulfiram), blood thinner (warfarin).

Drug-Food Interactions: No interaction found/established.

Drug-Disease Interactions: Before taking MEGATRUM OINTMENT, let your doctor know if have any allergic reactions to iodine or povidone, overactive thyroid gland (hyperthyroidism), or any other thyroid diseases, liver, and kidney problems.

• SILVER NITRATE
• LITHIUM
• AMPRENAVIR
• RITONAVIR
• DISULFIRAM
• WARFARIN
• TAUROLIDINE
• TIPRANAVIR
• HYDROGEN PEROXIDE
• TANNIC ACID

• Use mild soap while taking baths and prefer warm baths.
• Avoid harsh products on your skin.
• Do not scratch or pick your skin to avoid infecting the affected area.
• Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
• Do not walk barefoot at places like gym showers to prevent bacterial infections.

• Thyroid function monitoring (thyroid function tests like T3, T4, and TSH levels) is recommended in patients to check on overactive thyroid gland function, possibly due to iodine absorption into the body. 
• Regular monitoring of electrolytes is necessary since iodine is possibly absorbed into the body and causes an imbalance of electrolytes.
• It is better to take an electrocardiograph (ECG) if you notice rapid heartbeat (tachycardia).
• Taking a blood osmolarity test is advised since MEGATRUM OINTMENT may cause iodine absorption leading to abnormal blood concentration. 
• Kidney function monitoring is advised in patients since MEGATRUM OINTMENT may affect kidney disease patients with renal impairment.

Skin infection: Skin infection occurs when the skin is broken, cut or wounded. This skin infection allows pathogenic microorganisms to enter and invade the tissues surrounding the wound.

Burns: It is a type of cell injury and other skin tissues due to heat, overexposure to the sun, fire, chemical or electric contact. Skin burns can cause sepsis, increasing the chance of skin infections caused by bacteria, viruses, fungi or protozoa. Burns are of three types: first-degree, second degree and third-degree.