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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Composition :

METHOTREXATE-1000MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Merex 1000 mg Injection

Merex 1000 mg Injection belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis and severe psoriasis. Merex 1000 mg Injection is also used to treat cancer such as breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), bone cancer, and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Merex 1000 mg Injection contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Merex 1000 mg Injection prevents and stops the growth of cancer cells, thereby helps treat cancer. Merex 1000 mg Injection treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

Merex 1000 mg Injection will be administered by a qualified healthcare professional; do not self-administer. In some cases, Merex 1000 mg Injection may cause side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience any of the side effects persistently.

Do not take Merex 1000 mg Injection if you are pregnant or breastfeeding. Merex 1000 mg Injection may cause dizziness and fatigue, so avoid driving or operating machinery. Avoid consuming alcohol whilst on treatment with Merex 1000 mg Injection. If you are due to undergo any surgery, including dental surgery, inform the doctor that you are receiving Merex 1000 mg Injection. Do not have any vaccinations during treatment with Merex 1000 mg Injection without consulting your doctor. Inform your doctor about your medications and health condition to rule out any unpleasant side effects.

Uses of Merex 1000 mg Injection

Rheumatoid arthritis, Psoriasis, Cancer

Directions for Use

Merex 1000 mg Injection will be administered by a qualified healthcare professional; do not self-administer.

Medicinal Benefits

Merex 1000 mg Injection belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis including polyarticular juvenile rheumatoid arthritis (arthritis in children) and severe psoriasis. Merex 1000 mg Injection helps treat rheumatoid arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Merex 1000 mg Injection treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Merex 1000 mg Injection is used to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Merex 1000 mg Injection prevents and stops the growth of cancer cells by interfering with DNA production.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Merex 1000 mg Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

Drug Warnings

Do not take Merex 1000 mg Injection if you are allergic to any of its contents; if you are pregnant or breastfeeding. Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, liver, lung or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if are due to have any, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Merex 1000 mg Injection may cause a serious, life-threatening reaction. If you experience symptoms such as rash, itching, hives, throat tightness, trouble swallowing, swelling of the face, throat, lips, or tongue; runny or stuffy nose, lightheadedness or dizziness, chest pain, difficulty breathing, wheezing, or feeling faint, consult your doctor immediately. Inform your doctor if you are undergoing radiation therapy; if you receive Merex 1000 mg Injection while you are being treated with radiation therapy for cancer, it may cause damage to the skin, bones, or other parts of the body.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateEtodolac
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Merex 1000 mg Injection 40 ml:
Co-administration of Etretinate with Merex 1000 mg Injection 40 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Merex 1000 mg Injection 40 ml is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateEtodolac
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Co-administration of Merex 1000 mg Injection 40 ml with etodolac can increase the level and effects of Merex 1000 mg Injection 40 ml. This can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Merex 1000 mg Injection 40 ml and etodolac, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateDicloxacillin
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Co-administration of Merex 1000 mg Injection 40 ml with dicloxacillin can increase the levels and effects of Merex 1000 mg Injection 40 ml. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Merex 1000 mg Injection 40 ml and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateLeflunomide
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Coadministration of leflunomide with Merex 1000 mg Injection 40 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Merex 1000 mg Injection 40 ml, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MethotrexateTolmetin
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Coadministration of Merex 1000 mg Injection 40 ml with tolmetin can increase the levels and side effects of Merex 1000 mg Injection 40 ml.

How to manage the interaction:
Although there is a possible interaction between tolmetin and Merex 1000 mg Injection 40 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateHuman immunoglobulin
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Taking Human immunoglobulin with Merex 1000 mg Injection 40 ml may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Human immunoglobulin with Merex 1000 mg Injection 40 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
MethotrexateHydroxychloroquine
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Combine use of hydroxychloroquine with Merex 1000 mg Injection 40 ml may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between hydroxychloroquine and Merex 1000 mg Injection 40 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexatePhenylbutazone
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Coadministration of phenylbutazone with Merex 1000 mg Injection 40 ml may increase the levels and side effects of phenylbutazone.

How to manage the interaction:
Although there is a possible interaction between phenylbutazone and Merex 1000 mg Injection 40 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateDexlansoprazole
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Co-administration of Merex 1000 mg Injection 40 ml with Dexlansoprazole can increase the levels and side effects of Merex 1000 mg Injection 40 ml.

How to manage the interaction:
Although there is a possible interaction between Merex 1000 mg Injection 40 ml and Dexlansoprazole, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as tiredness, dizziness, fainting, unusual bleeding or bruising, chills, fever, sore throat, or body pains. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateNitrous oxide
Severe
How does the drug interact with Merex 1000 mg Injection 40 ml:
Combine use of nitrous oxide with Merex 1000 mg Injection 40 ml may increase the levels and side effects of nitrous oxide.

How to manage the interaction:
Although there is a possible interaction between nitrous oxide and Merex 1000 mg Injection 40 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, pale skin, easy bruising or bleeding, unusual weakness, mouth sores, black or bloody stools, and decreased urine output, consult the doctor. Do not discontinue any medications without doctors advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Merex 1000 mg Injection acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby providing relief from rheumatoid arthritis.

Merex 1000 mg Injection works by suppressing the overactive immune system that is responsible for causing psoriasis. Merex 1000 mg Injection interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis.

Merex 1000 mg Injection may affect fertility in men and women. Consult your doctor if you have any concerns regarding this.

Merex 1000 mg Injection causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Merex 1000 mg Injection may make your skin sensitive to sunlight. Therefore, avoid prolonged or unnecessary exposure to sunlight or ultraviolet light such as tanning beds and sunlamps. Wear protective clothing, sunglasses, and sunscreen while going out.

Drug-Drug Interactions Checker List

  • CISPLATIN
  • MERCAPTOPURINE
  • AZATHIOPRINE
  • TETRACYCLINE
  • CHLORAMPHENICOL
  • SULFASALAZINE

Special Advise

  • Women of child-bearing potential must use effective contraception whilst on treatment with Merex 1000 mg Injection and for at least 6 months after the last dose.
  • If you are a male, you and your partner should use reliable contraception during treatment with Merex 1000 mg Injection and for at least 3 months after the last dose.
  • Merex 1000 mg Injection may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Psoriasis: It is a chronic autoimmune skin condition that causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints, and dry skin.

Cancer: It is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer, namely benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy. 

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