Mesbro Solution 3 ml

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹220

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₹33.0 Cashback (15%)

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About Mesbro Solution 3 ml

Mesbro Solution 3 ml belongs to a class of medication known as 'cytoprotectant' primarily used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). Our body breaks down the anticancer agent (Ifosfamide) to form a chemical (acrolein) that can harm and irritate the bladder. Mesbro Solution 3 ml reduces the risk of inflammation and bleeding in the bladder due to other anti-cancer medications.

Mesbro Solution 3 ml contains 'Mesna', a chemo-protectant medicine. It works by altering the breakdown of anti-cancer agents (Ifosfamide) found in urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Mesbro Solution 3 ml should be used as advised by your physician. Avoid using more than the recommended dose. The dose of medicine will be advised by your doctor based on your health condition. In some cases, this medicine may cause certain side effects such as nausea, vomiting, headache, flushing (sense of warmth in the face, ears, neck, and trunk), lethargy, rash, diarrhea, light-headedness, abdominal pain, flu-like symptoms and fever. Most of these side effects of Mesbro Solution 3 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Mesbro Solution 3 ml is not recommended if you are allergic to it or any of its ingredients. Women of childbearing age should use an effective birth control method to prevent getting pregnant. While utilising Mesbro Solution 3 ml to track your CBC, your doctor could advise routine urine and blood tests (blood cell count). Because of various underlying clinical disorders, including thrombocytopenia, Mesbro Solution 3 ml is contraindicated for usage in hematuria. While using Mesbro Solution 3 ml, it is advisable to consume at least 1-2 litres of liquids every day. Due to significant adverse effects, this medication should not be used in pregnant or nursing women; thus, consult your doctor before beginning treatment with Mesbro Solution 3 ml.

Uses of Mesbro Solution 3 ml

Ifosfamide-induced hemorrhagic cystitis.

Directions for Use

Respirator solution: Mesbro Solution 3 ml is meant for inhalation/instillation (tracheopulmonary use) only and not to be injected. Read the instruction leaflet carefully before using it. Use as prescribed by the doctor.

Medicinal Benefits

Mesbro Solution 3 ml is a member of the 'chemoprotectant' class of drugs, which are principally used to stop urine bleeding caused by the anticancer drug ifosfamide (ifosfamide-induced hemorrhagic cystitis). Additionally, it lessens the chance that anti-cancer medications would induce bladder irritation and bleeding. It includes Mesna, which detoxifies the urotoxic ifosfamide (anti-cancer medication) metabolites by chemically interacting with them. Additionally, it binds to other urotoxic metabolites and prevents their bladder-damaging effects.

Storage

Keep Mesbro Solution 3 ml out of the sight and reach of children.

Side effects of Mesbro Solution 3 ml

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Low White Blood Cell Count

Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
Get sufficient sleep and manage stress which helps in improving white blood cell count.
Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Chest Pain

Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
Take rest and refrain from doing physical activity for a while, and restart after a few days.
Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Low Potassium Levels In Blood

Talk to your doctor about oral potassium supplements.
Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Do not use Mesbro Solution 3 ml if you are allergic to it or any of its ingredients. Mesbro Solution 3 ml should be used under the supervision of a doctor only. An effective birth control method should be used to avoid pregnancy in women of childbearing age. Maintain a 6-month gap between your last dose of name and your next pregnancy. Regular urine and blood test should be done while using this medicine to monitor your CBC (blood cell count). It is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. It is important to drink at least 1 litre of fluid daily while using Mesbro Solution 3 ml. This medicine is known to cause blurry vision and dizziness, so do not drive or operate machinery.

Drug-Drug Interactions

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

Empty your bladder frequently in the first 24 hours of chemotherapy (cancer treatment). If any pain occurs during urination, let your doctor know it.
Nausea can occur as a side effect of chemotherapy. Eat small and frequent meals to avoid it, or you can take any anti-nausea medicine.
Sleep at least 8 hours a day and take plenty of rest.
Maintain good nutrition. Eat home-cooked and freshly prepared food. Avoid junk, oily and spicy food.

Side Effects of Mesbro Solution 3 ml

Nausea
Headache
Flushing (sense of warmth in the face, ears, neck and trunk)
Lethargy
Rash
Diarrhea
Lightheadedness
Abdominal pain
Flu-like symptoms
Fever

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Author Details

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:47 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Mesbro Solution 3 ml work?

Our body breaks down anticancer agents like ifosfamide or cyclophosphamide to form a chemical known as acrolein, which can harm and irritate the bladder. Mesbro Solution 3 ml works by making this natural chemical less harmful or toxic. However, Mesbro Solution 3 ml does not change ifosfamide's anti-cancer effects.

What is an autoimmune disorder?

An autoimmune disease is a condition where the immune system targets the body's healthy tissues, leading to discomfort, edema, and damage. Nephritis, systemic lupus erythematosus, and rheumatoid arthritis are a few examples of autoimmune diseases.

Can Mesbro Solution 3 ml be taken along with anti-coagulant or blood thinner?

No, Mesbro Solution 3 ml should not be taken along with anti-coagulant like warfarin, heparin or coumarin as it might increase the risk of bleeding and lead to serious complications.

In addition to bleeding what are the other complications which can occur in hemorrhagic cystitis?

In addition to bladder bleeding in hemorrhagic cystitis, an individual might also experience bladder wall scarring, decreased bladder size (atrophy), severe systemic infection (urosepsis), and urinary obstruction.

Drug-Drug Interactions Checker List

ANISINDIONE
DICUMAROL
WARFARIN

Special Advise

Regular blood and urine test are required while using Mesbro Solution 3 ml.
Mesbro Solution 3 ml may interfere with enzymatic creatinine phosphokinase (CPK) activity tests that use a thiol compound (N-acetylcysteine) for CPK reactivation. This may result in a falsely low CPK level. Inform your doctor about the use of Mesbro Solution 3 ml.
Mesbro Solution 3 ml may interfere with a certain laboratory test (for urinary ketones), possibly causing false test results. Hence inform your doctor or laboratory personnel about the use of this medicine.

Disease/Condition Glossary

Ifosfamide-induced Hemorrhagic cystitis: It is a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). It occurs when an individual undergoes planned chemotherapy (for cancer treatment). During chemotherapy, an anticancer medication called 'ifosfamide' causes inflammation and bleeding of the bladder, which is passed into the urine. The colour of urine may vary from pink to red in colour.