Mesna Injection 1's

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹32.5

(Inclusive of all Taxes)

₹4.9 Cashback (15%)

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Non returnable*

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Prescription drug

Whats That

About Mesna Injection

Mesna Injection belongs to a class of medication known as 'cytoprotectant' primarily used to prevent Hemorrhagic cystitis (a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). Our bodies degrade the anticancer drug (ifosfamide) to generate a compound (acrolein) that can injure and irritate the bladder. Mesna Injection decreases the risk of bladder irritation and bleeding caused by other anti-cancer drugs.

Mesna Injection contains 'Mesna', a chemo-protectant medicine that alters the breakdown of anti-cancer agents (Ifosfamide) found in the urine, making it less toxic. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Mesna Injection will be administered to your vein by a trained healthcare professional; hence, do not self-administer. In some cases, this medicine may cause certain side effects such as nausea, vomiting, headache, flushing (sense of warmth in the face, ears, neck, and trunk), lethargy, rash, diarrhea, light-headedness, abdominal pain, flu-like symptoms, fever, and injection site reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Mesna Injection is not recommended if you are allergic to it or any of its ingredients. An effective birth control measure should be taken to avoid pregnancy in women of a mother-bearing you’re your doctor may suggest regular urine and blood test while receiving Mesna Injection to monitor your CBC (blood cell count). Mesna Injection is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. It is advised to drink at least 1-2 litres of fluid daily while receiving Mesna Injection. This medicine should be avoided in pregnant and breastfeeding populations due to serious side effects; hence inform your doctor before administration.

Uses of Mesna Injection

Ifosfamide-induced hemorrhagic cystitis.

Directions for Use

Mesna Injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Mesna Injection belongs to a class of medication known as 'chemoprotectant' primarily used to prevent bleeding into the urine by a particular anticancer medicine known as ifosfamide (ifosfamide-induced hemorrhagic cystitis). It also reduces the risk of inflammation and bleeding in the bladder by receiving anti-cancer medication. It contains Mesna, which works by reacting chemically with the urotoxic ifosfamide (anti-cancer medicines) metabolites, resulting in their detoxification. In addition, it binds to other urotoxic metabolites and inhibits their effects on the bladder.

Storage

Keep Mesna Injection out of the sight and reach of children.

Side effects of Mesna Injection

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Low White Blood Cell Count

Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
Get sufficient sleep and manage stress which helps in improving white blood cell count.
Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Chest Pain

Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
Take rest and refrain from doing physical activity for a while, and restart after a few days.
Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Low Potassium Levels In Blood

Talk to your doctor about oral potassium supplements.
Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug Warnings

Do not take this injection if you are allergic to Mesna Injection or any of its ingredients. An effective birth control method should be used to avoid pregnancy in women of childbearing age. Maintain a three-month gap between your last dose of Mesna Injection and your next pregnancy. Regular urine and blood test should be done while receiving Mesna Injection to monitor your CBC (blood cell count). It is not indicated for use in hematuria due to other underlying pathological conditions like thrombocytopenia. This medicine is known to cause blurry vision and dizziness, so do not drive or operate machinery.

Drug-Drug Interactions

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

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Diet & Lifestyle Advise

Empty your bladder frequently in the first 24 hours of chemotherapy (cancer treatment). If any pain occurs during urination, let your doctor know it.
Nausea can occur as a side effect of chemotherapy. Eat small and frequent meals to avoid it, or you can take any anti-nausea medicine.
Sleep at least 8 hours a day and take plenty of rest.
Maintain good nutrition. Eat home-cooked and freshly prepared food. Avoid junk, oily and spicy food.

Side Effects of Mesna Injection

Nausea
Headache
Flushing (sense of warmth in the face, ears, neck and trunk)
Lethargy
Rash
Diarrhea
Lightheadedness
Abdominal pain
Flu-like symptoms
Fever
Injection site reactions

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Author Details

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:47 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Mesna Injection work?

Our body breaks down anticancer agents like ifosfamide or cyclophosphamide to form a chemical known as acrolein, which can harm and irritate the bladder. Mesna Injection works by making this natural chemical less harmful or toxic. However, Mesna Injection does not change ifosfamide's anti-cancer effects.

Can Mesna Injection be taken along with anti-coagulant or blood thinner?

No, Mesna Injection should not be taken with an anti-coagulant like warfarin, heparin or coumarin as it might increase the risk of bleeding and lead to serious complications.

What is an autoimmune disorder?

An autoimmune disorder is a condition in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage. Some autoimmune disorders are rheumatoid arthritis, systemic lupus erythematosus or nephritis.

Can Mesna Injection change the color of urine?

Please inform your doctor if you observe any change in the urine colour (like if you have red/pink-coloured urine).

In addition to bleeding what are the other complications which can occur in hemorrhagic cystitis?

In addition to bladder bleeding in hemorrhagic cystitis, an individual might also experience bladder wall scarring, decreased bladder size (atrophy), severe systemic infection (urosepsis), and urinary obstruction.

Drug-Drug Interactions Checker List

WARFARIN
DICUMAROL
ANISINDIONE

Special Advise

Regular blood and urine test are required while receiving Mesna Injection.
Mesna Injection may interfere with enzymatic creatinine phosphokinase (CPK) activity tests that use a thiol compound (N-acetylcysteine) for CPK reactivation. This may result in a falsely low CPK level. Inform your doctor about the use of Mesna Injection.
Mesna Injection may interfere with a certain laboratory test (for urinary ketones), possibly causing false test results. Hence inform your doctor or laboratory personnel about the use of this medicine.

Disease/Condition Glossary

Ifosfamide-induced Hemorrhagic cystitis: It is a condition that causes bleeding in the urine due to the effect of anticancer agents (Ifosfamide). It occurs when an individual undergoes planned chemotherapy (for cancer treatment). During chemotherapy, an anticancer medication called 'ifosfamide' causes inflammation and bleeding of the bladder, which is passed into the urine. The colour of urine may vary from pink to red in colour.