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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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Consume Type

PARENTERAL

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Not Returnable

Expires on or after

Apr-24

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About Methofast 15 Injection 3 ml

Methofast 15 Injection 3 ml belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis and severe psoriasis. Methofast 15 Injection 3 ml is also used to treat cancer such as breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), bone cancer, and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Methofast 15 Injection 3 ml contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Methofast 15 Injection 3 ml prevents and stops the growth of cancer cells, thereby helps treat cancer. Methofast 15 Injection 3 ml treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

Methofast 15 Injection 3 ml will be administered by a qualified healthcare professional; do not self-administer. In some cases, Methofast 15 Injection 3 ml may cause side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience any of the side effects persistently.

Do not take Methofast 15 Injection 3 ml if you are pregnant or breastfeeding. Methofast 15 Injection 3 ml may cause dizziness and fatigue, so avoid driving or operating machinery. Avoid consuming alcohol whilst on treatment with Methofast 15 Injection 3 ml. If you are due to undergo any surgery, including dental surgery, inform the doctor that you are receiving Methofast 15 Injection 3 ml. Do not have any vaccinations during treatment with Methofast 15 Injection 3 ml without consulting your doctor. Inform your doctor about your medications and health condition to rule out any unpleasant side effects.

Uses of Methofast 15 Injection 3 ml

Rheumatoid arthritis, Psoriasis, Cancer

Directions for Use

Methofast 15 Injection 3 ml will be administered by a qualified healthcare professional; do not self-administer.

Medicinal Benefits

Methofast 15 Injection 3 ml belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis including polyarticular juvenile rheumatoid arthritis (arthritis in children) and severe psoriasis. Methofast 15 Injection 3 ml helps treat rheumatoid arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Methofast 15 Injection 3 ml treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Methofast 15 Injection 3 ml is used to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Methofast 15 Injection 3 ml prevents and stops the growth of cancer cells by interfering with DNA production.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Methofast 15 Injection 3 ml

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

Drug Warnings

Do not take Methofast 15 Injection 3 ml if you are allergic to any of its contents; if you are pregnant or breastfeeding. Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, liver, lung or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if are due to have any, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Methofast 15 Injection 3 ml may cause a serious, life-threatening reaction. If you experience symptoms such as rash, itching, hives, throat tightness, trouble swallowing, swelling of the face, throat, lips, or tongue; runny or stuffy nose, lightheadedness or dizziness, chest pain, difficulty breathing, wheezing, or feeling faint, consult your doctor immediately. Inform your doctor if you are undergoing radiation therapy; if you receive Methofast 15 Injection 3 ml while you are being treated with radiation therapy for cancer, it may cause damage to the skin, bones, or other parts of the body.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateDicloxacillin
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Methofast 15 Injection 3 ml:
Co-administration of Etretinate with Methofast 15 Injection 3 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Methofast 15 Injection 3 ml is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateDicloxacillin
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Co-administration of Methofast 15 Injection 3 ml with dicloxacillin can increase the levels and effects of Methofast 15 Injection 3 ml. This can increase the risk or severity of serious infections.

How to manage the interaction:
Although there is a possible interaction between Methofast 15 Injection 3 ml and dicloxacillin, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, paleness, fatigue, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateThalidomide
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Using thalidomide together with Methofast 15 Injection 3 ml can increase the risk of developing blood clots.

How to manage the interaction:
Although there is a possible interaction between thalidoamide and Methofast 15 Injection 3 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as chest pain, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, consult your doctor. Do not stop using any medications without consulting to a doctor.
MethotrexateAcitretin
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Co-administration of Acitretin with Methofast 15 Injection 3 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is a possible interaction between Acitretin with Methofast 15 Injection 3 ml, you can take these medicines together if only when prescribed by a doctor. Do not discontinue any medications without talking to a doctor.
MethotrexateEverolimus
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Coadministration of Everolimus with Methofast 15 Injection 3 ml can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Methofast 15 Injection 3 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
MethotrexateHydroxychloroquine
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Combine use of hydroxychloroquine with Methofast 15 Injection 3 ml may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between hydroxychloroquine and Methofast 15 Injection 3 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateFlucytosine
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Combine use of entecavir with Methofast 15 Injection 3 ml may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between everolimus and Methofast 15 Injection 3 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateSirolimus
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Co-administration of Sirolimus with Methofast 15 Injection 3 ml can increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between sirolimus and Methofast 15 Injection 3 ml, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
MethotrexateNaproxen
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Coadministration of Methofast 15 Injection 3 ml with Naproxen can increase the levels and side effects of Methofast 15 Injection 3 ml.

How to manage the interaction:
Taking Methofast 15 Injection 3 ml with Naproxen together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateNitrous oxide
Severe
How does the drug interact with Methofast 15 Injection 3 ml:
Combine use of nitrous oxide with Methofast 15 Injection 3 ml may increase the levels and side effects of nitrous oxide.

How to manage the interaction:
Although there is a possible interaction between nitrous oxide and Methofast 15 Injection 3 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, pale skin, easy bruising or bleeding, unusual weakness, mouth sores, black or bloody stools, and decreased urine output, consult the doctor. Do not discontinue any medications without doctors advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CISPLATIN
  • MERCAPTOPURINE
  • AZATHIOPRINE
  • TETRACYCLINE
  • CHLORAMPHENICOL
  • SULFASALAZINE

Special Advise

  • Women of child-bearing potential must use effective contraception whilst on treatment with Methofast 15 Injection 3 ml and for at least 6 months after the last dose.
  • If you are a male, you and your partner should use reliable contraception during treatment with Methofast 15 Injection 3 ml and for at least 3 months after the last dose.
  • Methofast 15 Injection 3 ml may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Your doctor may advise regular blood tests, kidney and liver tests to monitor your condition.

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Psoriasis: It is a chronic autoimmune skin condition that causes the skin to multiply ten times faster than normal. This leads to a rapid build-up of skin cells, causing scaling on the skin surface. Symptoms include inflamed, red, raised patches of skin, soreness around the patches, itching, burning sensations, painful, swollen joints, and dry skin.

Cancer: It is a genetic change in which the cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer, namely benign (localized) and metastatic (spread to the whole body). Cancer growth can be prevented by chemotherapy (by strong antibiotics), radiation, and stem cell therapy. 

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