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Reviewed By Sunny S , MBBS
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Manufacturer/Marketer

Pillix Health Care

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Metoshine AM 50 Tablet

Metoshine AM 50 Tablet belongs to the class of drugs known as antihypertensive, used to treat hypertension (increased blood pressure). Hypertension (high blood pressure) is a lifelong or chronic condition in which the force exerted by the blood against the artery walls becomes so high that it leads to heart disease. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of stroke and heart attacks.

Metoshine AM 50 Tablet is a fixed-dose combination composed of two medicines, namely: Amlodipine and Metoprolol. Amlodipine is a calcium channel blocker while Metoprolol belongs to a group of medicines called beta-blockers. Metoprolol relaxes blood vessels by blocking the action of certain natural substances in your body. On the other hand, Amlodipine widens and relaxes the blood vessels making the heart more efficient at pumping blood throughout the body. Together, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. Metoshine AM 50 Tablet is prescribed to adults and children more than six years of age.

Metoshine AM 50 Tablet can be taken with or without food as directed by your physician. Swallow the whole tablet with a glass of water. Do not crush, chew, or break it. Metoshine AM 50 Tablet is preferable to take at the same time every day for better results. Metoshine AM 50 Tablet is generally safe to consume. Some people may experience nausea, vomiting, diarrhoea, fatigue, headache, low heart rate, and breathlessness. Most of the side effects of Metoshine AM 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Don't stop taking $ name without talking to your doctor first. Stopping Metoshine AM 50 Tablet gradually may cause changes in your heart rhythm and blood pressure, cause chest pain, or a heart attack. Your doctor will lower your dose gradually over some time to help prevent these symptoms. It is advisable to drink plenty of fluids while taking this medicine to overcome muscle weakness, dry mouth, and extreme thirst. Do not take grapefruit or grapefruit juices with Metoshine AM 50 Tablet as it can increase the concentration of Metoshine AM 50 Tablet and worsen its side effects.

Uses of Metoshine AM 50 Tablet

High blood pressure (hypertension), Heart-related chest pain (angina pectoris)

Directions for Use

Metoshine AM 50 Tablet can be taken orally with or without food as directed by your physician. Swallow the whole tablet with approximately a glass of water. Do not crush, chew or break it

Medicinal Benefits

Metoshine AM 50 Tablet is used to treat heart-related conditions like angina (chest pain) and high blood pressure. Amlodipine is a calcium channel blocker that inhibits the entry of calcium (ions) across the heart that relaxes and widens the heart smooth muscles for better blood flow. Metoprolol plays a vital role in relaxing our blood vessels and lowering blood pressure by blocking the action of certain natural substances in your body.  Besides this, Metoshine AM 50 Tablet help prevent spasm of the coronary artery and reduces how hard the heart has to work to pump blood around the body, lowering its oxygen requirements. It improves an individual’s tolerance to physical activity and exercise to keep their blood pressure normal during exercise. As a result, heart rate is at maximum, and exercise does not affect the blood pressure in anyways.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Metoshine AM 50 Tablet

  • Oedema (swelling)
  • Dizziness
  • Flushing
  • Palpitation
  • Vertigo
  • Bradycardia (slow heart rate)
  • Headache
  • Feeling exhausted
  • Swollen ankles
  • Flushing
  • Stomach upset
  • Increased levels of potassium in the blood
  • Dry mouth
  • Change in taste
  • Blurred vision
  • Difficulty in breathing
  • Cold fingers or toes

Drug Warnings

Don't stop taking the medication without talking to your doctor first. Stopping Metoshine AM 50 Tablet gradually may cause changes in your heart rhythm and blood pressure, cause chest pain, or a heart attack. Your doctor will lower your dose gradually over a period of time to help prevent these symptoms. Metoshine AM 50 Tablet can cause low blood sugar (hypoglycaemia). This medication should be used with caution if you have diabetes, particularly if you are taking insulin or other diabetes drugs that may cause low blood sugar. This medication can also induce low blood sugar in babies, children and adults who do not have diabetes. Do not take Metoshine AM 50 Tablet if you have asthma or similar breathing difficulties. It could make your asthma severe.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
AmlodipinePrimidone
Severe

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Metoshine AM 50 Tablet:
Using Metoshine AM 50 Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Metoshine AM 50 Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
AmlodipinePrimidone
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Using Metoshine AM 50 Tablet and primidone together may lower Metoshine AM 50 Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Metoshine AM 50 Tablet with primidone can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineRifabutin
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Using Metoshine AM 50 Tablet and rifabutin together may lower Metoshine AM 50 Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Metoshine AM 50 Tablet with rifabutin, but it can be taken if a doctor has advised it. Consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
AmlodipineSimvastatin
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Taking simvastatin with Metoshine AM 50 Tablet may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Metoshine AM 50 Tablet with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
AmlodipineCarbamazepine
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Coadministration of Metoshine AM 50 Tablet and carbamazepine together may significantly reduce Metoshine AM 50 Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Although there is an interaction between Metoshine AM 50 Tablet with carbamazepine, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact the doctor immediately. Do not stop using any medications without talking to a doctor.
AmlodipineEnzalutamide
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Using a combination of Metoshine AM 50 Tablet and enzalutamide may drastically lower Metoshine AM 50 Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Taking Metoshine AM 50 Tablet with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineTizanidine
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Co-administration of Tizanidine and Metoshine AM 50 Tablet can increase the risk or severity of developing side effects like low blood pressure.

How to manage the interaction:
Although co-administration of Metoshine AM 50 Tablet with tizanidine can result in an interaction, it can be taken when a doctor has advised it. However, if you experience headache, dizziness, palpitations, or irregular heart rate while taking these drugs, contact the doctor immediately. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not discontinue any medications without consulting the doctor.
AmlodipineDolasetron
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Using dolasetron together with Metoshine AM 50 Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Metoshine AM 50 Tablet and Dolasetron, but it can be taken if prescribed by a doctor. If you have any of these symptoms, like feeling dizzy, lightheaded, or your heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineLemborexant
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Coadministration of lemborexant and Metoshine AM 50 Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Metoshine AM 50 Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.
AmlodipineIdelalisib
Severe
How does the drug interact with Metoshine AM 50 Tablet:
Coadministration of Metoshine AM 50 Tablet and Idelalisib may raise Metoshine AM 50 Tablet levels in the blood this may lead to serious side effects (irregular heart rhythm, fluid retention, swelling, heart failure, and abnormally low blood pressure).

How to manage the interaction:
Although taking Metoshine AM 50 Tablet with idelalisib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness or fainting, sudden, unexplained weight gain, swelling of the hands, ankles, or feet, chest discomfort, or trouble breathing while taking these drugs, consult the doctor. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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AMLODIPINE-5MG+METOPROLOL-50MGFruit juices, Fruits
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+METOPROLOL-50MGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Amlodipine and Metoprolol with grapefruit and grapefruit juice significantly increases the metabolism of Amlodipine. Avoid taking Amlodipine and Metoprolol with grapefruit and grapefruit juice.

Diet & Lifestyle Advise

  • Keep your weight under control with BMI 19.5-24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol then only one serving for women and two servings for men is advisable.
  • Quitting smoking is the best strategy to lower the risk of heart disease. 
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
  • Monitor your blood pressure daily and if there is too much fluctuation then immediately contact your doctor.
  • Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil can help in lowering your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Metoshine AM 50 Tablet Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend to discontinue it.

In case, you have missed a dose of Metoshine AM 50 Tablet , you are advised to take it as soon as you remember. However, try not to miss a dose in the first place, if it's time for you to take your next dose, then do not take both doses together. Take only one dose, taking a double dose of Metoshine AM 50 Tablet will lead to low blood pressure.

When you are taking a beta-blocker, your health care provider may recommend that you limit your consumption of bananas and other high potassium foods including papaya, tomato, avocado and kale.

Metoshine AM 50 Tablet can be safely taken as long as your doctor has prescribed it to you. Conditions such as high blood pressure are life-long conditions and one should not abruptly discontinue it without discussing it with a doctor.

Yes, Metoshine AM 50 Tablet is contraindicated in people with known allergy to any of the components of this medicine. It should be avoided in people with severe kidney or liver impairment and in people with anuria (reduction or absence of urine). It should also be avoided in women who are in the second and third trimesters of their pregnancy.

Drug-Drug Interactions Checker List

  • ATENOLOL
  • BISOPROLOL
  • METOPROLOL
  • NEBIVOLOL
  • SOTALOL
  • LISINOPRIL
  • ENALAPRIL
  • DILTIAZEM
  • PRAZOSIN
  • THEOPHYLLINE
  • FLUOXETINE
  • PAROXETINE
  • DIGOXIN
  • KETOCONAZOLE
  • ITRACONAZOLE
  • RITONAVIR

Disease/Condition Glossary

Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg and, diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.

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