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Written By Divya L , PharmaD
Reviewed By Sunny S , MBBS
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Composition :

DESMOPRESSIN-60MCG

Manufacturer/Marketer :

Ferring Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Minirin Melt 60 mcg Tablet

Minirin Melt 60 mcg Tablet is a hormone analogue that belongs to the class of ‘antihemophilic agents’ primarily used to treat diabetes insipidus, post-hypophysectomy polyuria (extreme urination) polydipsia (extreme thirst), and bedwetting. Diabetes insipidus is a condition in which the body fails to control water balance, resulting in excessive urination. Hypophysectomy is the surgical removal of the hypophysis (pituitary gland).

Minirin Melt 60 mcg Tablet contains Desmopressin, a human-made form (synthetic) of Vasopressin. Vasopressin is an antidiuretic (that controls fluid balance) hormone, synthesized in the pituitary gland's hypothalamus. When your body cannot produce enough vasopressin, Minirin Melt 60 mcg Tablet is given to replace a low vasopressin level. It mimics the natural hormone, vasopressin and works by reabsorbing water from the kidneys, which controls excessive thirst and urination in diabetes insipidus. It also decreases the amount of urine produced and controls bedwetting in children. Being an anti-haemophilic agent, Minirin Melt 60 mcg Tablet also reduces bleeding tendency in haemophilia (bleeding disorder) by promoting the release of blood clotting factors.

Your doctor will decide the dosage depending on your medical condition. The common side effects of Minirin Melt 60 mcg Tablet include headache, nausea, abdominal cramp, flushing (sense of warmth in the face, ears, neck, and trunk). Although not everyone experiences these side effects, if they occur, seek medical attention.

Before starting Minirin Melt 60 mcg Tablet , let your doctor know if you have any medical history of severe kidney disease or hyponatremia (low sodium levels in your body), extreme thirst, uncontrolled high blood pressure, heart failure, and fluid retention. While using Minirin Melt 60 mcg Tablet , limit water and other fluids' intake since it may lead to electrolyte imbalance. Avoid drinking coffee, tea, cola, energy drinks, or other caffeine sources before bedtime, leading to increased urination. Pregnant and breastfeeding women should consult their doctor before using Minirin Melt 60 mcg Tablet . Do not take or stop this medicine, if the doctor did not advise you to do so.

Uses of Minirin Melt 60 mcg Tablet

Diabetes insipidus, Post-hypophysectomy polyuria (polydipsia), and Bedwetting.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Minirin Melt 60 mcg Tablet is a hormone analogue that treats diabetes insipidus, post-hypophysectomy polyuria (extreme urination) or polydipsia (excessive thirst), and bedwetting. It contains Desmopressin, a synthetic form of Vasopressin (antidiuretic hormone), which mimics the natural hormone, vasopressin and works by limiting the amount of water eliminated in the urine, thus controlling excessive thirst and urination in diabetes insipidus. It also decreases the amount of urine produced, thereby preventing the urinary bladder from filling up at night time and controls bedwetting in children. Being an anti-haemophilic agent, Minirin Melt 60 mcg Tablet also reduces bleeding tendency in haemophilia (bleeding disorder) by promoting the release of blood clotting factors. 

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Before starting Minirin Melt 60 mcg Tablet , let your doctor know if you have any medical history of severe kidney disease, hyponatremia (low sodium levels in your body), extreme thirst, uncontrolled high blood pressure, heart failure, fluid/mineral imbalance (cystic fibrosis), bleeding/clotting problems, and fluid retention. While using Minirin Melt 60 mcg Tablet , limit water and other fluids' intake since it may lead to electrolyte imbalance. Inform your doctor if you have any allergic reactions or lactose intolerance before using Minirin Melt 60 mcg Tablet . Please consult your doctor before starting Minirin Melt 60 mcg Tablet if you are pregnant, planning to conceive or are a breastfeeding mother. It is not recommended to consume alcohol since it may worsen the side effects and increase urination. 

Drug-Drug Interactions

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DesmopressinFluticasone furoate
Critical
DesmopressinDeflazacort
Critical

Drug-Drug Interactions

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DesmopressinFluticasone furoate
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Co-administration of Minirin Melt 60 mcg Tablet together with fluticasone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood.

How to manage the interaction:
If you have to use Minirin Melt 60 mcg Tablet and Fluticasone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinDeflazacort
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Co-administration of Deflazacort and Minirin Melt 60 mcg Tablet may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
DesmopressinTorasemide
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Co-administration of Torasemide can make Minirin Melt 60 mcg Tablet may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Melt 60 mcg Tablet and Torasemide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinCortisone
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Co-administration of Cortisone and Minirin Melt 60 mcg Tablet may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Melt 60 mcg Tablet and Cortisone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinPrednisone
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Coadministration of Prednisone and Minirin Melt 60 mcg Tablet may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Melt 60 mcg Tablet and prednisone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinBeclometasone
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Co-administration of Minirin Melt 60 mcg Tablet together with Beclomethasone may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Melt 60 mcg Tablet and Beclomethasone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinCiclesonide
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Co-administration of Bumetanide and Minirin Melt 60 mcg Tablet may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Melt 60 mcg Tablet and Ciclesonide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinPrednisolone
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Co-administration of Prednisolone and Minirin Melt 60 mcg Tablet may increase the risk of hyponatremia (low levels of sodium in the blood).

How to manage the interaction:
Taking Prednisolone with Minirin Melt 60 mcg Tablet is not generally advised as they lead to an interaction, they can be taken together if advised by a doctor. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DesmopressinFludrocortisone
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Using Minirin Melt 60 mcg Tablet together with fludrocortisone may increase the risk of hyponatremia( a condition associated with low levels of salt in the blood).

How to manage the interaction:
Taking Minirin Melt 60 mcg Tablet with Fludrocortisone is not recommended, but it can be taken if prescribed by a doctor. However, if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination and sudden weight gain contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DesmopressinFluticasone Propionate
Critical
How does the drug interact with Minirin Melt 60 mcg Tablet:
Co-administration of Minirin Melt 60 mcg Tablet together with fluticasone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood.

How to manage the interaction:
Coadministration of Minirin Melt 60 mcg Tablet and Fluticasone Propionate is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination and sudden weight gain contact doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Minirin Melt 60 mcg Tablet for more than once per day. Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Minirin Melt 60 mcg Tablet .
  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
  • Eat at regular intervals.
  • Avoid drinking coffee, tea, cola, energy drinks, or other caffeine sources before bedtime since it can lead to increased urination. 
  • Avoid activities that cause dehydration, such as excessive physical exercise or spending time in the heat.

Habit Forming

No

Therapeutic Class

ANTIHEMOPHILICS

Author Details

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Drug-Diseases Interactions

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DESMOPRESSIN-60MCGOther disorders of kidney and ureter, not elsewhere classified
Severe

Drug-Diseases Interactions

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DESMOPRESSIN-60MCGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Minirin Melt 60 mcg Tablet:
Minirin Melt 60 mcg Tablet is not recommended for people with moderate to severe renal impairment (creatinine clearance less than 50 mL/min).

How to manage the interaction:
The use of Minirin Melt 60 mcg Tablet is contraindicated in patients with moderate to severe kidney impairment.

FAQs

Minirin Melt 60 mcg Tablet contains Desmopressin, a human-made form of vasopressin (antidiuretic hormone). When your body cannot produce enough vasopressin, Minirin Melt 60 mcg Tablet is used to replace it. It helps treat diabetes insipidus, post-hypophysectomy polyuria or polydipsia, and bedwetting by causing water reabsorption in the kidneys and reducing the amount of urine to be filled up in the bladder.

Minirin Melt 60 mcg Tablet does not cause weight gain. But it may cause fluid overload as a side effect by reducing the amount of fluid to be urinated. This fluid overload can result in weight gain.

Minirin Melt 60 mcg Tablet does not cure bedwetting, but it helps control bedwetting. It is usually prescribed at the night time to prevent frequent urination.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Optimal intake of fluids is recommended. However, avoid excess intake of water and other liquids like coffee, tea, cola, and energy drinks, leading to worsening of electrolyte imbalance.

Drug-Drug Interactions Checker List

  • LAMOTRIGINE
  • ESCITALOPRAM
  • FLUOXETINE
  • SERTRALINE
  • FUROSEMIDE

Special Advise

  • Regular monitoring of electrolytes is essential to rule out chances of fluid imbalance.
  • If you are frequently urinating, it is advised to consult your endocrinologist to check for any hormonal abnormalities.
  • You may also be advised for any CT, or MRI scans to know the functioning of your pituitary gland.
  • Kidney functioning tests may be advised by your doctor to monitor for any renal impairment.

Disease/Condition Glossary

Diabetes insipidus: It is a condition in which the body fails to control fluid balance, resulting in excessive urination. It is caused due to two conditions: A) Central diabetes insipidus is a condition when your pituitary gland cannot produce enough vasopressin (an antidiuretic hormone that maintains fluid balance). B) Nephrogenic diabetes insipidus: Though you make enough vasopressin, your kidneys may not respond to vasopressin that regulates fluid balance.

Hypophysectomy: It is the surgical removal of the hypophysis (pituitary gland) to treat cancerous or benign tumours.

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