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Written By Divya L , PharmaD
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Minirin Nasal Spray 2.5 ml

Minirin Nasal Spray 2.5 ml belongs to the class of 'antidiuretics', primarily used as replacement therapy in central cranial diabetes insipidus, a condition in which the body fails to control water balance, resulting in excessive urination. Minirin Nasal Spray 2.5 ml is also used to manage temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma or surgery in the pituitary gland.

Minirin Nasal Spray 2.5 ml contains Desmopressin, a human-made form (synthetic) of Vasopressin. Vasopressin is an antidiuretic (that controls fluid balance) hormone synthesized in the hypothalamus of the pituitary gland. When your body cannot produce enough vasopressin, Minirin Nasal Spray 2.5 ml is given to replace a low level of vasopressin. It mimics the natural hormone vasopressin and works by reabsorbing water from the kidneys, which controls excessive thirst and urination. Thus, it prevents dehydration. 

Minirin Nasal Spray 2.5 ml is for intranasal use only. Your doctor will decide the dosage depending on your medical condition. The common side effects of Minirin Nasal Spray 2.5 ml include conjunctivitis/red eyes, weakness, headache, nasal congestion/stuffy nose, rhinitis/runny nose, nose bleeds, nausea, upset stomach, abdominal pain, and flushing (sense of warmth) of the face. These side effects may not occur in every patient using this medication and gradually resolve over time. If the side effects persist longer or worsen, please seek a doctor's advice.

Before starting Minirin Nasal Spray 2.5 ml, let your doctor know if you have any medical history of severe kidney disease or hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart problems/failure, swelling or scarring of the nasal lining, and illnesses that cause fluid/mineral imbalance. While using Minirin Nasal Spray 2.5 ml, avoid drinking large amounts of fluid, including alcohol, since it could lead to the build-up of water in the body. Pregnant and breastfeeding women should consult their doctor before using Minirin Nasal Spray 2.5 ml. 

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Whats That

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Non returnable*
COD available

Online payment accepted

Consume Type

NASAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Minirin Nasal Spray 2.5 ml

Central cranial diabetes insipidus, polyuria, and polydipsia.

Medicinal Benefits

Minirin Nasal Spray 2.5 ml is a hormone analogue that contains Desmopressin, a synthetic form of Vasopressin (an antidiuretic hormone that controls fluid balance). Minirin Nasal Spray 2.5 ml mimics the natural hormone vasopressin and works by limiting the amount of water eliminated in the urine, thus controlling excessive thirst and urination. Minirin Nasal Spray 2.5 ml is not indicated for the treatment of nephrogenic diabetes insipidus.

Side Effects of Minirin Nasal Spray 2.5 ml

  • Conjunctivitis/red eyes
  • Weakness
  • Headache
  • Nose bleeds
  • Nasal congestion/stuffy nose
  • Rhinitis/runny nose
  • Nausea
  • Upset stomach
  • Abdominal pain
  • Flushing of the face 

Directions for Use

Intranasal solution/Nasal spray: Read the instruction leaflet (if provided) carefully before using and prime the nozzle, if required. Blow your nose. Tilt your head back and insert the tip of the nozzle into your nostril. Spray into the nostril while breathing in slightly. When pressing down the pump, apply even pressure and press down quickly to produce a consistent spray. Repeat the same process for another nostril if required. Wipe off the tip with a clean tissue and replace the cap.Nasal drops: Read the instruction leaflet (if provided) carefully and use it as suggested by the doctor. Insert the tip of the dropper into the end of the medicine dispensing tube marked with measurements. Squeeze the dropper until the solution has reached the desired measurement. You can also use a syringe to fill the tube. Hold the tip of the tube, gently insert it into one nostril, and put the other end of the tube into your mouth. Hold your breath, tilt back your head, and blow slowly through your mouth into the tube so the solution reaches your nose.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Before starting Minirin Nasal Spray 2.5 ml, let your doctor know if you have any history of allergic reactions to antidiuretic hormones, severe kidney disease, hyponatremia (low sodium levels in your body), excessive fluid intake, high blood pressure, heart failure, illnesses that cause fluid/mineral imbalance (cystic fibrosis), and fluid retention. Please consult your doctor before starting Minirin Nasal Spray 2.5 ml if you are pregnant, planning to conceive or are a breastfeeding mother. Alcohol consumption may interfere with the working of Minirin Nasal Spray 2.5 ml; hence it is advised to limit or avoid its intake. Minirin Nasal Spray 2.5 ml should be used in children only when prescribed by the doctor.

Therapeutic Class

HORMONES

Drug-Drug Interactions

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DesmopressinDexamethasone
Critical
DesmopressinFludrocortisone
Critical

Drug-Drug Interactions

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DesmopressinDexamethasone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Minirin Nasal Spray 2.5 ml with Dexamethasone may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Dexamethasone and Minirin Nasal Spray 2.5 ml can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DesmopressinFludrocortisone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Using Minirin Nasal Spray 2.5 ml together with fludrocortisone may increase the risk of hyponatremia( a condition associated with low levels of salt in the blood).

How to manage the interaction:
Taking Minirin Nasal Spray 2.5 ml with Fludrocortisone is not recommended, but it can be taken if prescribed by a doctor. However, if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination and sudden weight gain contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DesmopressinDeflazacort
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Deflazacort and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
DesmopressinFluticasone furoate
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Minirin Nasal Spray 2.5 ml together with fluticasone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood.

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Fluticasone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinPrednisone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Coadministration of Prednisone and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and prednisone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinFluticasone Propionate
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Minirin Nasal Spray 2.5 ml together with fluticasone may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood.

How to manage the interaction:
Coadministration of Minirin Nasal Spray 2.5 ml and Fluticasone Propionate is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination and sudden weight gain contact doctor immediately. Do not discontinue any medications without consulting a doctor.
DesmopressinCortisone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Cortisone and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Cortisone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinBeclometasone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Minirin Nasal Spray 2.5 ml together with Beclomethasone may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Beclomethasone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinTorasemide
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Torasemide can make Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Torasemide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinCiclesonide
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Bumetanide and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Ciclesonide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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DESMOPRESSIN-0.1MGOther disorders of kidney and ureter, not elsewhere classified
Severe

Drug-Diseases Interactions

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DESMOPRESSIN-0.1MGOther disorders of kidney and ureter, not elsewhere classified
Severe
How does the disease interact with Minirin Nasal Spray 2.5 ml:
Minirin Nasal Spray 2.5 ml is not recommended for people with moderate to severe renal impairment (creatinine clearance less than 50 mL/min).

How to manage the interaction:
The use of Minirin Nasal Spray 2.5 ml is contraindicated in patients with moderate to severe kidney impairment.

Drug-Drug Interactions Checker List

  • LOPERAMIDE
  • CHLORPROPAMIDE
  • GLIBENCLAMIDE
  • CLOFIBRATE
  • NAPROXEN
  • IBUPROFEN
  • CARBAMAZEPINE
  • CHLORPROMAZINE
  • FUROSEMIDE
  • LITHIUM
  • FLUOXETINE
  • SERTRALINE

Diet & Lifestyle Advise

  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains.
  • Reduce the amount of salt and protein in your diet, which will help your kidneys to produce less urine.
  • Avoid drinking coffee, tea, cola, energy drinks, or other caffeine sources before bedtime since it can lead to increased urination. 
  • Avoid activities that cause dehydration, such as excessive physical exercise or spending time in the heat.
  • Optimal water intake is recommended to prevent dehydration due to excessive urination.

Habit Forming

No

Special Advise

  • Regular monitoring of electrolytes is essential to rule out chances of fluid imbalance.
  • If you are more frequently urinating than usual, it is advised to consult your endocrinologist to check for any hormonal abnormalities.
  • Your doctor may advise kidney functioning tests to monitor for renal impairment.

Author Details

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Disease/Condition Glossary

Diabetes insipidus: It is a condition in which the body fails to control fluid balance, resulting in excessive urination. It is caused due to following: 

A) Central diabetes insipidus: It is caused when the pituitary gland cannot produce enough vasopressin (an antidiuretic hormone that maintains fluid balance). It is characterized by excessive thirst (polydipsia) and excessive urination (polyuria).

B) Nephrogenic diabetes insipidus: Though you make enough vasopressin, your kidneys may not respond to vasopressin that regulates fluid balance.

Minirin Nasal Spray 2.5 ml Substitute

Substitutes safety advice
  • Minirin 0.1 Tablet 15's

    32.49per tablet
  • D PRESSIN TABLET

    32.31per tablet
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