NEOCALM PLUS TABLET belongs to a class of drugs called 'antipsychotics' used to prevent and treat schizophrenia (a mental illness). Additionally, NEOCALM PLUS TABLET may be used to anxiety and depression over a short period. Schizophrenia is a mental disorder that affects a person's ability to feel, think and behave clearly. Anxiety is a mental health disorder associated with fear, worry, and excessive nervousness that may interfere with daily activities. Depression is a mood disorder associated with symptoms such as sadness, unable to sleep properly or enjoy life as you used to do.

NEOCALM PLUS TABLET combination composed of two different medicines, namely, Trifluoperazine and Trihexyphenidyl. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behaviour, and emotions. Thereby, NEOCALM PLUS TABLET helps in controlling psychotic illness, relieving depression, lightening the mood, and relieving anxiety symptoms such as fear and panic. On the other hand, Trihexyphenidyl is an anticholinergic agent that acts on the nervous system and corrects some of the chemical imbalances that cause some side effects such as shaking of hands and muscle spasms due to Trifluoperazine.

Take NEOCALM PLUS TABLET as prescribed by your doctor. You are advised to take NEOCALM PLUS TABLET for as long as your doctor has prescribed it for you based on your medical condition. Some people may experience nausea, constipation, dryness in the mouth, sedation, weight gain, orthostatic hypotension (sudden lowering of blood pressure on standing), urinary retention, increased prolactin level in the blood, dizziness, blurred vision, and nervousness. Most of these side effects of NEOCALM PLUS TABLET do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to NEOCALM PLUS TABLET or any other medicines, please tell your doctor. Avoid taking NEOCALM PLUS TABLET if you are pregnant, especially in the third trimester, as it may cause adverse effects in the baby such as breathing problems, muscle stiffness or weakness, shaking, etc. Please consult a doctor if you are pregnant or breastfeeding. NEOCALM PLUS TABLET should be used with caution in elderly patients above 65 years, as there is an increased risk of adverse reactions. Avoid consuming alcohol along with NEOCALM PLUS TABLET as it could lead to increased drowsiness and dizziness. Consult your doctor before giving this medicine to your child. Keep your doctor informed about your medicines and health condition and rule out any side effects. 

NEOCALM PLUS TABLET combination composed of two different medicines, namely; Trifluoperazine and Trihexyphenidyl used to prevent and treat relapses of schizophrenia (a mental illness). Additionally, NEOCALM PLUS TABLET may be used to anxiety and depression over a short period. Trifluoperazine inhibits the dopamine (chemical messenger) receptors in the brain. Dopamine is involved in regulating mood, behavior, and emotions. Thereby, NEOCALM PLUS TABLET helps in controlling psychotic illness, relieving depression, lighten the mood, and relieve anxiety symptoms such as fear and panic. However, it may cause side effects such as involuntary movements (shaking of hands, muscle spasms, etc.). On the other hand, Trihexyphenidyl is used to treat and prevent side effects such as involuntary movements (shaking of hands, muscle spasms) caused by Trifluoperazine. Trihexyphenidyl exerts a direct inhibitory effect upon the parasympathetic nervous system. It works by relaxing the muscles and nerve impulses that control muscle functioning. NEOCALM PLUS TABLET improves muscle control and reduces stiffness, thereby helps the muscles move naturally. 

• Nausea
• Constipation
• Dry mouth
• Sedation
• Weight gain
• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Urinary retention
• Increased prolactin level in the blood
• Dizziness
• Abdominal Pain
• Excessive sweating
• Decreased blood pressure
• Urine retention
• Blurred vision
• Nervousness

If you are allergic to NEOCALM PLUS TABLET or any other medicines, please tell your doctor. Avoid taking NEOCALM PLUS TABLET if you are pregnant, especially in the third trimester, as it may cause adverse effects in the baby such as breathing problems, muscle stiffness or weakness, shaking, etc. Please consult a doctor if you are pregnant or breastfeeding. NEOCALM PLUS TABLET should be used with caution in elderly patients above 65 years, as there is an increased risk of adverse reactions. Do not discontinue NEOCALM PLUS TABLET on your own. Inform your doctor before taking NEOCALM PLUS TABLET if you have glaucoma, prostate problems, urination problems, stomach ulcers, acidity, myasthenia gravis (muscle problems), tardive dyskinesia (involuntary facial movements), alcoholism, high blood pressure, heart, liver, or kidney problems. Talk to your doctor immediately if you experience hallucinations. NEOCALM PLUS TABLET may make you sweat less, making you more likely to get heatstroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. NEOCALM PLUS TABLET may cause drowsiness and dizziness, do not drive unless you are alert. Avoid consuming alcohol along with NEOCALM PLUS TABLET as it could lead to increased drowsiness and dizziness. 

Drug-Drug Interaction: NEOCALM PLUS TABLET may have interaction with high blood pressure-lowering medicines (guanethidine), opioid pain killers (codeine), medicines used to decrease saliva and lung secretions (atropine, procyclidine), antipsychotics (promazine, prochlorperazine, chlorpromazine, aripiprazole, lurasidone, olanzapine, risperidone, quetiapine, trifluoperazine, escitalopram, duloxetine), anticonvulsants (lamotrigine, clonazepam, alprazolam, pregabalin), antiparkinson drug (levodopa), blood thinner (warfarin), a medicine used to treat iron poisoning (desferrioxamine), heart-related medicines (disopyramide, procainamide, quinidine, amiodarone, sotalol), antihistamine (diphenhydramine), anti-cholinergic (benztropine), and mild pain killers/fever-reducing agent (acetaminophen).

Drug-Food Interaction: NEOCALM PLUS TABLET may interact with alcohol. Therefore, avoid alcohol intake while taking NEOCALM PLUS TABLET as it may cause adverse effects such as severe dizziness or fainting, irregular heartbeats, drowsiness, uncontrollable movements, fits, drowsiness, high or low body temperature.

Drug-Disease Interaction: Avoid taking NEOCALM PLUS TABLET if you have blood disorders, liver problems, or the heart's inability to maintain adequate circulation. If you have Parkinson’s disease, fits, narrow-angle glaucoma, myasthenia gravis (muscle weakness), enlarged prostate gland, dementia (decline in memory, intelligence, or communication), uncontrolled high blood pressure, high cholesterol, diabetes, have a family history of stroke or blood clots, liver, heart or brain problems, inform your doctor before taking NEOCALM PLUS TABLET.

• GUANETHIDINE
• CODEINE
• ATROPINE
• PROCYCLIDINE
• PROMAZINE
• PROCHLORPERAZINE
• CHLORPROMAZINE
• ARIPIPRAZOLE
• LURASIDONE
• OLANZAPINE
• RISPERIDONE
• QUETIAPINE
• TRIFLUOPERAZINE
• LAMOTRIGINE
• CLONAZEPAM
• PREGABALIN
• LEVODOPA
• WARFARIN
• DESFERRIOXAMINE
• DISOPYRAMIDE
• PROCAINAMIDE
• QUINIDINE
• AMIODARONE
• SOTALOL
• DIPHENHYDRAMINE
• BENZTROPINE MESYLATE
• ESCITALOPRAM
• DULOXETINE
• ALPRAZOLAM
• ACETAMINOPHEN

• Maintain a healthy diet and exercise regularly.
• Include a diet rich in iron, folate, and magnesium. 
• Regularly attend therapy sessions.
• Perform meditation and yoga.
• Follow a regular sleep pattern.
• Avoid smoking and alcohol consumption.
• Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

• If you are going to have a special X-ray examination of the spinal cord or brain involving metrizamide (chemical), inform your doctor that you are taking NEOCALM PLUS TABLET.
• Blood tests are recommended while taking NEOCALM PLUS TABLET to monitor blood counts and liver functioning.
• This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Schizophrenia: It is a mental disorder that affects a person's ability to feel, think and behave clearly. The symptoms include hallucinations, thought or movement disorders, delusions (misbelief), lack of emotion, sleep problems, isolation from family and friends and difficulty in doing daily activities.

Anxiety: It is a mental health disorder associated with fear, worry and excessive nervousness that may interfere with daily activities. The anxiety symptoms include feeling more stress than required for that event and lack of ability to set aside restlessness and worry. Anxiety can be treated by psychotherapy (meeting a psychologist) or medications.

Depression: It is a mood disorder associated with symptoms such as sadness, unable to sleep properly or enjoy life as you used to do.