Neoclovir 500 mg Injection 1's

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹591.5

(Inclusive of all Taxes)

₹88.7 Cashback (15%)

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Non returnable*

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Prescription drug

Whats That

About Neoclovir 500 mg Injection

Neoclovir 500 mg Injection belongs to the class of 'antivirals' that treats herpes simplex (herpes simplex virus/HSV-1 and HSV-2) infections and varicella-zoster (shingles) infections. Herpes simplex infection, commonly known as herpes, is a viral infection that causes contagious sores, often around the mouth or genitals. Shingle is a viral infection with painful rashes or blisters on the skin.

Neoclovir 500 mg Injection is composed of Acyclovir, which works by killing and stopping the growth of herpes simplex virus type 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV).

Neoclovir 500 mg Injection will be administered by a healthcare professional; do not self-administer. Common side effects of Neoclovir 500 mg Injection include nausea, vomiting, loss of appetite, itching, hive-like rash, sensitivity to light (photosensitivity), swelling, redness and tenderness at the injection site. These side effects may not occur in every patient using this medication and gradually resolve over time. If the side effects persist longer or worsen, please inform your doctor.

Let your doctor know if you are allergic to any medications. Inform your doctor if you have a weakened immune system, breathing problems, an electrolyte imbalance, and liver or kidney diseases before starting Neoclovir 500 mg Injection. Pregnant and breastfeeding women should inform their doctor before starting Neoclovir 500 mg Injection. Avoid alcohol consumption while on treatment with Neoclovir 500 mg Injection to enable your body to fight off infections. Neoclovir 500 mg Injection is given to children only when advised by a doctor based on the child's age and weight.

Uses of Neoclovir 500 mg Injection

Herpes simplex and varicella-zoster (shingles) infections.

Directions for Use

Neoclovir 500 mg Injection will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Neoclovir 500 mg Injection treats viral infections caused by the herpes simplex and varicella-zoster viruses. It consists of Acyclovir, an antiviral drug. It works by killing and stopping the growth of the virus. Neoclovir 500 mg Injection effectively treats herpes simplex encephalitis (brain inflammation by herpes simplex virus) and neonatal herpes simplex virus infection. Neoclovir 500 mg Injection is also useful in preventing the reactivation of the cytomegalovirus infection in seropositive (showing a positive result of a blood test for a particular antibody) patients following bone marrow transplantation.

Storage

Keep Neoclovir 500 mg Injection out of the sight and reach of children.

Side effects of Neoclovir 500 mg Injection

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Toxic epidermal necrolysis (Lyell's syndrome) (A Life-Threatening Skin Condition That Causes The Top Layer Of Skin To Detach From The Lower Layers)

Eat foods rich in vitamins C and E, and healthy fats.
Consider soft foods like smoothies, soups, and scrambled eggs.
Take supplements like vitamins C and E, zinc, and omega-3 fatty acids under medical supervision.
Include anti-inflammatory foods like omega-3 rich foods, berries, leafy greens, and spices.
Avoid allergens and consider an elimination diet.
Practice gentle skin care with non-irritating cleansers and moisturizers.
Keep skin well-moisturized with fragrance-free products.
Monitor for complications like infection and temperature regulation.

Severe Allergic Reaction

If you experience or encounter any severe allergic reaction, stop using medication and consult the doctor right away.
Tell your doctor about the allergic reaction, including the medication taken and any symptoms experienced.
Your doctor will evaluate the severity of the reaction and determine the best course of action.
To ensure a full recovery, follow your doctor's advice, attend scheduled follow-up appointments, and undergo recommended tests to monitor progress and adjust treatment as needed.

Swelling Under The Skin

Here are the steps to manage angioedema (Swelling Under The Skin) as a side effect of medication:

If you experience angioedema, inform your doctor immediately. Treatment can help keep the swelling under control.
Seek medical attention if symptoms are severe, such as difficulty breathing or swallowing.
Follow your doctor's instructions to manage symptoms, which may include stopping or adjusting the medication that triggered angioedema.
Your doctor may also recommend antihistamines, steroids, or other treatments to reduce swelling and inflammation.
Make dietary and lifestyle changes as recommended, such as avoiding trigger foods or reducing stress.
Monitor your condition closely and track your symptoms to report them to your doctor.
Consult your doctor again if symptoms worsen or do not improve or if you experience any new or concerning symptoms.

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Pain

Apply a hot/cold pack to the affected area.
Doing gentle exercises can help cope with pain by stretching muscles.
Get enough sleep. It helps enhance mood and lower pain sensitivity.
Avoid alcohol, smoking and tobacco as they can increase pain.
Follow a well-balanced meal.
Meditation and massages may also help with pain.

Drug Warnings

Inform your doctor if you use prescription, non-prescription drugs, and herbal products before starting Neoclovir 500 mg Injection. Inform your doctor if you are allergic to any components in Neoclovir 500 mg Injection. Keep your doctor informed of your medical history before starting Neoclovir 500 mg Injection. If you are pregnant or breastfeeding, you must inform the healthcare provider. Do not consume alcohol while being treated with Neoclovir 500 mg Injection.

Drug-Drug Interactions

AciclovirCidofovir

Critical

AciclovirEverolimus

Severe

Drug-Drug Interactions

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AciclovirCidofovir

Critical

How does the drug interact with Neoclovir 500 mg Injection:
Co-administration of Cidofovir with Acyclovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Neoclovir 500 mg Injection with Cidofovir is not recommended, please consult your doctor before taking it. You should consult a doctor if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, weakness, and palpitations. Do not stop using any medications without talking to a doctor.

AciclovirEverolimus

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Coadministration of Neoclovir 500 mg Injection with Everolimus may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking Neoclovir 500 mg Injection with Everolimus together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, breathing difficulty, muscle pains, dizziness, or palpitations. Do not discontinue any medications without consulting a doctor.

AciclovirIodamide

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Coadministration of Iodamide contrast with Neoclovir 500 mg Injection may increase the risk or severity of kidney injury.

How to manage the interaction:
Before undergoing any imaging procedure let your doctor know you are on Neoclovir 500 mg Injection treatment.

AciclovirMetrizamide

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Coadministration of Metrizamide in contrast with Neoclovir 500 mg Injection may increase the risk or severity of kidney disorder.

How to manage the interaction:
Before undergoing any imaging procedure, let your doctor know you are on Neoclovir 500 mg Injection treatment. Look out for signs such as vomiting, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, or weakness. Consult the doctor immediately.

AciclovirSirolimus

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Coadministration of Neoclovir 500 mg Injection with Sirolimus may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking Neoclovir 500 mg Injection with Sirolimus can result in an interaction, it can be taken if your doctor has advised it. However, if you experience vomiting, a decrease in hunger, irregular urine, weight gain or loss, swelling, difficulty breathing, muscle pain, or weakness, consult a doctor.

AciclovirAmphotericin b

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Coadministration of Neoclovir 500 mg Injection with Amphotericin B can increase the risk or severity of kidney disorder.

How to manage the interaction:
Taking Neoclovir 500 mg Injection with Amphotericin b together can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you experience irregular urination, muscle ache, shortness if breath, or palpitations. Do not discontinue any medications without consulting a doctor.

AciclovirTenofovir alafenamide

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Coadministration of Neoclovir 500 mg Injection with Tenofovir alafenamide may increase the risk or severity of kidney injury.

How to manage the interaction:
Taking Neoclovir 500 mg Injection with tenofovir alafenamide can result in an interaction. However, if the benefits outweigh the risks, your doctor will prescribe them. Contact a doctor immediately if you experience symptoms such as decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medication without consulting your doctor.

AciclovirTenofovir disoproxil

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Coadministration of Neoclovir 500 mg Injection with Tenofovir Disoproxil may increase the risk or severity of kidney disorder.

How to manage the interaction:
Coadministration of Neoclovir 500 mg Injection with Tenofovir disoproxil can result in an interaction, it can be taken when your doctor has advised it. Contact a doctor immediately if you experience decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medications without consulting a doctor.

AciclovirTizanidine

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Concomitant use of Neoclovir 500 mg Injection with Tizanidine can increase the risk of developing low blood pressure.

How to manage the interaction:
Coadministration of Neoclovir 500 mg Injection with Tizanidine can result in an interaction, but it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as dizziness, excessive sweating, or palpitations. Do not discontinue any medications without consulting a doctor.

AciclovirTacrolimus

Severe

How does the drug interact with Neoclovir 500 mg Injection:
Co-administration of Neoclovir 500 mg Injection with tacrolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Coadministration of Neoclovir 500 mg Injection with Tacrolimus can result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as decreased or increased urine output, sudden weight gain or loss, swelling, or shortness of breath. Do not discontinue any medications without first consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
Eat foods rich in antioxidants, such as berries, spinach, kidney beans, dark chocolate, etc.
Eat a healthy and balanced diet. Include vitamin and nutrient-rich food such as dark green, yellow, orange, and red vegetables and fruits as it helps to boost your immune system.
Opt for lean protein and whole grains.
Practise safe sex by using condoms; it helps reduce contact with body fluids from an infected person.
Never share personal items that can have your body fluids or blood on them, such as razor blades or toothbrushes.
Avoid sharing used needles, other injection or drug equipment.
Get tested for other sexually transmitted infections.

Side Effects of Neoclovir 500 mg Injection

Nausea
Vomiting
Loss of appetite
Itching
Hive-like rash
Sensitivity to light (photosensitivity)
Swelling, redness and tenderness at the injection site

Habit Forming

No

Therapeutic Class

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Author Details

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:46 AM IST

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Drug-Diseases Interactions

ACYCLOVIR-500MGOther disorders of kidney and ureter, not elsewhere classified

Severe

ACYCLOVIR-500MGVolume depletion

Moderate

Drug-Diseases Interactions

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ACYCLOVIR-500MGOther disorders of kidney and ureter, not elsewhere classified

Severe

How does the disease interact with Neoclovir 500 mg Injection:
Acyclovir should be used with caution to patients who have impaired kidney function. In patients with moderate to severe renal impairment, dosage modifications are advised.

How to manage the interaction:
The use of Neoclovir 500 mg Injection in kidney disease patients is not advised as it may increase the severity of kidney disease. Your doctor may adjust the dosing according to the severity of your kidney disease.

ACYCLOVIR-500MGVolume depletion

Moderate

How does the disease interact with Neoclovir 500 mg Injection:
Patients who are dehydrated may be more susceptible to nephrotoxicity from using acyclovir. Acyclovir should be infused intravenously over the course of an hour, along with appropriate hydration.

How to manage the interaction:
Neoclovir 500 mg Injection is excreted through the kidneys, dehydration may cause damage to kidney functions. Neoclovir 500 mg Injection infusion over an hour is recommended in dehydrated patients. Urine output should be monitored.

ACYCLOVIR-500MGCare involving dialysis

Moderate

How does the disease interact with Neoclovir 500 mg Injection:
Hemodialysis effectively removes acyclovir from the body. Following 6 hours of dialysis, it has been demonstrated that plasma levels of acyclovir decrease by 60%. After hemodialysis, acyclovir should be administered. If not, a second dosage might be administered following each hemodialysis session.

How to manage the interaction:
Patients undergoing hemodialysis should be given Neoclovir 500 mg Injection after completing hemodialysis as hemodialysis removes 60% of Neoclovir 500 mg Injection from the body.

FAQs

How does Neoclovir 500 mg Injection work?

Neoclovir 500 mg Injection treats viral infections caused by herpes simplex and varicella-zoster viruses by killing and stopping the growth of the virus.

In which conditions should I stay cautious while using Neoclovir 500 mg Injection?

Neoclovir 500 mg Injection should be used with proper caution and doctor consultation if you have any allergic reactions to medicines, liver or kidney diseases, weakened immune system, breathing problems, and an electrolyte imbalance.

I am undergoing vaccination this week. Can I use Neoclovir 500 mg Injection?

Please consult a doctor before you start Neoclovir 500 mg Injection if you are undergoing any immunizations/vaccinations, especially vaccines against the varicella virus.

Does Neoclovir 500 mg Injection cause any abnormal laboratory tests?

Neoclovir 500 mg Injection may elevate blood urea and creatinine levels that determine kidney functioning. It may also increase liver enzymes. Hence, seek medical advice before undergoing any laboratory examinations.

Drug-Drug Interactions Checker List

IBUPROFEN
NAPROXEN
CICLOSPORIN
MYCOPHENOLATE MOFETIL
LITHIUM
THEOPHYLLINE

Special Advise

You are advised to take proper precautions if you are infected with herpes to prevent the spread of infection to others through sexual contact or body fluids.

Disease/Condition Glossary

Herpes simplex infection: Herpes is a viral infection that commonly causes contagious sores around the mouth or genitalia. The herpes simplex virus is to blame. Herpes simplex virus (HSV-1 and HSV-2) and other types of herpes are the two main types. Oral secretions or skin sores can spread the HSV-1 virus, which causes oral herpes. Kissing or sharing private items like toothbrushes or eating utensils are other ways it can spread. Cold sores or fever blisters around the mouth or on the face are signs of HSV-1. Genital infections caused by HSV-2/genital herpes can be contracted by coming into close contact with an infected person's body fluids or sores/lesions. Inflamed papules and vesicles on the genital exterior are signs of the sexually transmitted infection genital herpes.

Shingles: It is a viral infection brought on by the varicella-zoster virus, which is also responsible for chickenpox. When someone has had chickenpox, the virus is permanently present in their body. After years, this virus reactivates and causes shingles. The skin may develop itchy blisters or rashes as symptoms.