Nexchio IT 40mg/150mg Tablet is a combination medicine used to treat acidity, gastro-oesophageal reflux disease (GERD), stomach ulcers (peptic ulcers, gastric ulcers due to H pylori), heartburn symptoms and Zollinger Ellison syndrome. Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach. A gastric ulcer occurs mainly due to a bacteria known as H pylori which irritate and weakens the upper protective layer or mucous of the stomach leading to sores and ulcer. 
 
Nexchio IT 40mg/150mg Tablet is a combination of two drugs, namely: Esomeprazole and Itopride. Esomeprazole is a proton pump inhibitor (PPIs) which works by blocking the action of an enzyme called gastric proton pump responsible for the production of stomach acid. Itopride is a gastroprokinetic agent which works by increasing the gastric emptying time, thereby improving the movement/motility of the food pipe, stomach and intestine. Together, Nexchio IT 40mg/150mg Tablet helps in preventing acid reflux, thereby providing relief from symptoms of excessive stomach acid production, which causes an ulcer. 
 
Take Nexchio IT 40mg/150mg Tablet 30-60 minutes before food/meal. Swallow Nexchio IT 40mg/150mg Tablet as a whole with a glass of water; do not chew or crush it. You are advised to take Nexchio IT 40mg/150mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, flatulence, stomach pain, constipation, and diarrhoea. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
On long-term treatment, Nexchio IT 40mg/150mg Tablet may cause osteoporosis, hypomagnesemia (low levels of magnesium), and may reduce the absorption of vitamin B12. Consult your doctor if you are pregnant or breastfeeding. Nexchio IT 40mg/150mg Tablet may cause dizziness, so drive only if you are alert. Nexchio IT 40mg/150mg Tablet should not be given to children as safety has not been established. Avoid consuming alcohol along with Nexchio IT 40mg/150mg Tablet as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.

Nexchio IT 40mg/150mg Tablet is a combination medicine used to treat acidity, gastro-oesophageal reflux disease (GERD), stomach ulcer and heartburn. Nexchio IT 40mg/150mg Tablet is a combination of two drugs, namely: Esomeprazole and Itopride. Esomeprazole belongs to a group of medicines called proton pump inhibitors, whereas itopride belongs to a group of medicines called prokinetic agents. Esomeprazole works by blocking the action of an enzyme called the gastric proton pump, responsible for the production of stomach acid. Itopride works by accelerating the gastric emptying time, thereby increasing the movement of the food pipe, intestine and stomach. Besides this, Itopride also has anti-emetic action, which prevents the symptom of nausea and vomiting. Together, Nexchio IT 40mg/150mg Tablet helps in preventing acid reflux, thereby providing relief from hyperacidity, ulcers and heartburn.  

• Headache
• Flatulence
• Stomach pain
• Constipation
• Diarrhoea

Do not take Nexchio IT 40mg/150mg Tablet if you are allergic to any of its contents; if you are taking nelfinavir (anti-HIV); if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. Inform your doctor before taking Nexchio IT 40mg/150mg Tablet if you have severe liver or kidney problems; if you are due to have Chromogranin A test. Consult your doctor if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. On long-term treatment, Nexchio IT 40mg/150mg Tablet may cause osteoporosis, hypomagnesemia (low levels of magnesium), and may reduce the absorption of vitamin B12. Consult your doctor if you are pregnant or breastfeeding. Nexchio IT 40mg/150mg Tablet may cause dizziness, so drive only if you are alert. Nexchio IT 40mg/150mg Tablet should not be given to children as safety has not been established. Avoid consuming alcohol along with Nexchio IT 40mg/150mg Tablet as it could lead to increased drowsiness and can elevate the production of stomach acid. 

Drug-Drug Interactions: Nexchio IT 40mg/150mg Tablet may interact with pain killers (aspirin, naproxen), an antidepressant (duloxetine, citalopram), anti-anxiety (diazepam), hypothyroidism (levothyroxine), blood thinner (clopidogrel), and vitamin (cyanocobalamin).

Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

Drug-Disease Interactions: Inform your doctor if you have gastrointestinal bleeding, mechanical obstruction or perforation, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, or hypomagnesemia (low levels of magnesium).

• ASPIRIN
• NAPROXEN
• DULOXETINE
• CITALOPRAM
• DIAZEPAM
• LEVOTHYROXINE SODIUM
• CLOPIDOGREL
• CYANOCOBALAMIN

• Eat smaller meals more often.
• Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
• Maintain a healthy weight by regular exercising.
• Avoid lying down after eating to prevent acid reflux.
• Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
• Practise relaxation techniques and avoid stress by doing yoga or meditation.
• Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
• Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.

• Inform your doctor if you are due to have Chromogranin A test.
• Regular tests of magnesium and calcium are suggested if you are on long-term treatment with Nexchio IT 40mg/150mg Tablet. 

Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets irritated or eroded, which leads to complications like GERD, hyperacidity, peptic ulcers and heartburn.

Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.

Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.