Nexchio IT Capsule 10's

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Sunny S , MBBS

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MRP ₹200

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Whats That

About Nexchio IT Capsule

Nexchio IT Capsule is a combination medicine used to treat acidity, gastro-oesophageal reflux disease (GERD), stomach ulcers (peptic ulcers, gastric ulcers due to H pylori), heartburn symptoms and Zollinger Ellison syndrome. Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus). Peptic ulcers are sores that develop on the inner lining of the intestine and stomach. A gastric ulcer occurs mainly due to a bacteria known as H pylori which irritate and weakens the upper protective layer or mucous of the stomach leading to sores and ulcer.

Nexchio IT Capsule is a combination of two drugs, namely: Esomeprazole and Itopride. Esomeprazole is a proton pump inhibitor (PPIs) which works by blocking the action of an enzyme called gastric proton pump responsible for the production of stomach acid. Itopride is a gastroprokinetic agent which works by increasing the gastric emptying time, thereby improving the movement/motility of the food pipe, stomach and intestine. Together, Nexchio IT Capsule helps in preventing acid reflux, thereby providing relief from symptoms of excessive stomach acid production, which causes an ulcer.

Take Nexchio IT Capsule 30-60 minutes before food/meal. Swallow Nexchio IT Capsule as a whole with a glass of water; do not chew or crush it. You are advised to take Nexchio IT Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as headache, flatulence, stomach pain, constipation, and diarrhoea. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

On long-term treatment, Nexchio IT Capsule may cause osteoporosis, hypomagnesemia (low levels of magnesium), and may reduce the absorption of vitamin B12. Consult your doctor if you are pregnant or breastfeeding. Nexchio IT Capsule may cause dizziness, so drive only if you are alert. Nexchio IT Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Nexchio IT Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about all the medicines and your health condition to rule out any side-effects.

Uses of Nexchio IT Capsule

Acidity, Gastro-oesophageal reflux disease (GERD), Stomach ulcer, Heartburn

Directions for Use

Take Nexchio IT Capsule 30-60 minutes before food/meal. Swallow Nexchio IT Capsule as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Nexchio IT Capsule is a combination medicine used to treat acidity, gastro-oesophageal reflux disease (GERD), stomach ulcer and heartburn. Nexchio IT Capsule is a combination of two drugs, namely: Esomeprazole and Itopride. Esomeprazole belongs to a group of medicines called proton pump inhibitors, whereas itopride belongs to a group of medicines called prokinetic agents. Esomeprazole works by blocking the action of an enzyme called the gastric proton pump, responsible for the production of stomach acid. Itopride works by accelerating the gastric emptying time, thereby increasing the movement of the food pipe, intestine and stomach. Besides this, Itopride also has anti-emetic action, which prevents the symptom of nausea and vomiting. Together, Nexchio IT Capsule helps in preventing acid reflux, thereby providing relief from hyperacidity, ulcers and heartburn.

Storage

Keep Nexchio IT Capsule out of reach and sight of children.

Side effects of Nexchio IT Capsule

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Gas Or Fart

Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:

Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

Constipation

Here are the steps to cope with constipation as a side effect of medication:

Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Dry Mouth

Here are the steps to Dry Mouth (xerostomia) caused by medication:

Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Drug Warnings

Do not take Nexchio IT Capsule if you are allergic to any of its contents; if you are taking nelfinavir (anti-HIV); if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. Inform your doctor before taking Nexchio IT Capsule if you have severe liver or kidney problems; if you are due to have Chromogranin A test. Consult your doctor if you experience unexplained weight loss, stomach pain, indigestion, vomit food or blood, or if you pass black stools. On long-term treatment, Nexchio IT Capsule may cause osteoporosis, hypomagnesemia (low levels of magnesium), and may reduce the absorption of vitamin B12. Consult your doctor if you are pregnant or breastfeeding. Nexchio IT Capsule may cause dizziness, so drive only if you are alert. Nexchio IT Capsule should not be given to children as safety has not been established. Avoid consuming alcohol along with Nexchio IT Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.

Drug-Drug Interactions

EsomeprazoleRilpivirine

Critical

EsomeprazoleClopidogrel

Severe

Drug-Drug Interactions

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EsomeprazoleRilpivirine

Critical

How does the drug interact with Nexchio IT Capsule:
Nexchio IT Capsule may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Nexchio IT Capsule with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.

EsomeprazoleClopidogrel

Severe

How does the drug interact with Nexchio IT Capsule:
Coadministration of Clopidogrel with Nexchio IT Capsule may reduce the effectiveness of clopidogrel.

How to manage the interaction:
Taking clopidogrel and Nexchio IT Capsule together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.

EsomeprazoleDasatinib

Severe

How does the drug interact with Nexchio IT Capsule:
Using Dasatinib together with Nexchio IT Capsule may decrease the levels of Dasatinib.

How to manage the interaction:
Although taking Nexchio IT Capsule together with Dasatinib can result in an interaction, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

EsomeprazoleMethotrexate

Severe

How does the drug interact with Nexchio IT Capsule:
Co-administration of methotrexate and Nexchio IT Capsule can increase the blood levels and side effects of methotrexate.

How to manage the interaction:
Although taking Nexchio IT Capsule with Methotrexate can result in an interaction, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience headache, dizziness, nausea and vomiting. Do not discontinue any medications without consulting a doctor.

EsomeprazoleAcalabrutinib

Severe

How does the drug interact with Nexchio IT Capsule:
Nexchio IT Capsule may interfere with the absorption of Acalabrutinib and reduce their efficacy.

How to manage the interaction:
Taking Nexchio IT Capsule with Acalabrutinib together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.

EsomeprazoleGefitinib

Severe

How does the drug interact with Nexchio IT Capsule:
Taking gefitinib with Nexchio IT Capsule may reduce the effectiveness of gefitinib.

How to manage the interaction:
Although taking Nexchio IT Capsule and Gefitinib together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is recommended to take Gefitionib 12 hours before or after taking Nexchio IT Capsule. Do not stop taking any medications without consulting a doctor.

EsomeprazoleNelfinavir

Severe

How does the drug interact with Nexchio IT Capsule:
Taking nelfinavir with Nexchio IT Capsule may decrease the effects of nelfinavir.

How to manage the interaction:
Although taking Nexchio IT Capsule and Nelfinavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.

EsomeprazoleAtazanavir

Severe

How does the drug interact with Nexchio IT Capsule:
Nexchio IT Capsule reduces the absorption of atazanavir, resulting in reduced efficacy of atazanavir.

How to manage the interaction:
Although there is a possible interaction between Nexchio IT Capsule and atazanavir, they can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.

EsomeprazoleCitalopram

Severe

How does the drug interact with Nexchio IT Capsule:
Combining Nexchio IT Capsule with Citalopram can increase the risk of irregular heart rhythm. .

How to manage the interaction:
Co-administration of Nexchio IT Capsule with Citalopram can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any symptoms like irregular heart rhythm, dizziness, fainting, or shortness of breath, it's important to contact your doctor immediately. Do not stop using any medications without a doctor's advice.

EsomeprazolePazopanib

Severe

How does the drug interact with Nexchio IT Capsule:
Nexchio IT Capsule decreases the absorption of Pazopanib. This results in reduced efficacy of Pazopanib.

How to manage the interaction:
Although taking Nexchio IT Capsule and Pazopanib can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting your doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Eat smaller meals more often.
Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Maintain a healthy weight by regular exercising.
Avoid lying down after eating to prevent acid reflux.
Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
Practise relaxation techniques and avoid stress by doing yoga or meditation.
Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.

Side Effects of Nexchio IT Capsule

Headache
Flatulence
Stomach pain
Constipation
Diarrhoea

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

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Author Details

Written By

Santoshini Reddy G

M Pharmacy

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:31 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Nexchio IT Capsule work?

Nexchio IT Capsule contains Esomeprazole and Itopride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Itopride works by accelerating gastric emptying and improves gastric sensitivity and tension. It also has anti-emetic action. Together, Nexchio IT Capsule helps in preventing acid reflux, thereby providing relief from acidity.

Does Nexchio IT Capsule cause diarrhoea?

Diarrhoea might be a side-effect of Nexchio IT Capsule . Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Can I lie down after having meals?

Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

Does Nexchio IT Capsule cause bone fractures?

Nexchio IT Capsule may increase the risk of bone fracture in the hip, spine or wrist. This mainly occurs in people taking higher doses of Nexchio IT Capsule for longer durations. Inform your doctor before taking Nexchio IT Capsule if you have osteoporosis or if you are taking corticosteroids.

Drug-Drug Interactions Checker List

ASPIRIN
NAPROXEN
DULOXETINE
CITALOPRAM
DIAZEPAM
LEVOTHYROXINE SODIUM
CLOPIDOGREL
CYANOCOBALAMIN

Special Advise

Inform your doctor if you are due to have Chromogranin A test.
Regular tests of magnesium and calcium are suggested if you are on long-term treatment with Nexchio IT Capsule .

Disease/Condition Glossary

Acidity: The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets irritated or eroded, which leads to complications like GERD, hyperacidity, peptic ulcers and heartburn.

Gastroesophageal reflux disease (GERD): It occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing.

Peptic ulcers: Peptic ulcers are sores that develop on the lining of the stomach and intestine due to erosion of stomach's protective lining. Symptoms include nausea, changes in appetite, bloody or dark stools, unexplained weight loss, vomiting, and indigestion.