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  3. Ngmine 250 Injection 1's

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Whats That

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Composition :

BIVALIRUDIN-250MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Ngmine 250 Injection

Ngmine 250 Injection belongs to the group of medicines called blood thinners used to prevent the formation of blood clots. Blood clots are formed to stop bleeding that occurs due to tissue injury. Though blood clots are useful for stopping bleeding, they may be harmful when abnormally formed within blood vessels as they block blood vessels and inhibit blood flow to essential organs such as the brain, heart, or lungs. Ngmine 250 Injection is used in combination with aspirin during Percutaneous transluminal coronary angioplasty (PTCA) and Percutaneous coronary intervention (PCI) (angioplasty procedures) in unstable angina patients to reduce the chance of blood clot formation.

Ngmine 250 Injection contains Bivalirudin, which works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. This results in lower cardiovascular events like myocardial infarction (heart attack) or other severe chest pain-related problems.

Ngmine 250 Injection will be administered by your doctor. So, do not self-administer. The dose of the medicine will be decided by your doctor based on your health condition. Ngmine 250 Injection may cause certain side effects such as nose bleeds, skin rash, bleeding in the bowels, blood in urine, low haemoglobin, thrombocytopenia (low platelets), hypersensitivity reactions, and elevations of liver enzyme levels. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Ngmine 250 Injection should not be used if you are allergic to it or if you ever had a brain stroke, bleeding in the brain or transient ischemic attack (stroke). Talk to your doctor before receiving Ngmine 250 Injection if you have/had a recent severe injury or surgery due to the risk of severe bleeding problems, have/had a heart problem, kidney disease or using any blood thinner medicine. Pregnant or breastfeeding mothers should inform the doctor before receiving this medicine. Ngmine 250 Injection is not recommended for children as efficacy and safety have not been established.

Uses of Ngmine 250 Injection

Myocardial infarction (heart attack)

Directions for Use

A trained healthcare professional will administer Ngmine 250 Injection. Hence do not self-administer.

Medicinal Benefits

Ngmine 250 Injection belongs to the group of medicines called antithrombolytic agents (direct thrombin inhibitors) used to prevent the formation of blood clots. Ngmine 250 Injection works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack) or stroke, especially in people who have had heart surgery, known as angioplasty.

Storage

Keep Ngmine 250 Injection out of the sight and reach of children.
Side effects of Ngmine 250 Injection

Drug Warnings

Do not receive Ngmine 250 Injection if you are allergic to it or if you have a medical condition that causes bleeding from the stomach or intestine, had a transient ischemic attack (stroke) or if you are suffering from severe liver disease. Let your doctor know if you have bleeding problems, had/have a recent serious injury or surgery, kidney/liver disease, or taking any blood thinner medicine before receiving this medicine. Consult your doctor immediately if you develop a medical condition called thrombotic thrombocytopenic purpura (blood disorder) while on treatment with Ngmine 250 Injection. Pregnant or breastfeeding mothers should inform their doctor before receiving this medicine. Ngmine 250 Injection is not recommended for children as efficacy and safety have not been established.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Ngmine 250 Injection:
When Etodolac is taken with Ngmine 250 Injection, the risk or severity of bleeding and haemorrhage increases.

How to manage the interaction:
Taking Ngmine 250 Injection with Estradiol can cause an interaction, consult a doctor before taking it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Co-administration of Mifepristone with Ngmine 250 Injection can increase the risk of negative side effects.

How to manage the interaction:
Taking Ngmine 250 Injection with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
How does the drug interact with Ngmine 250 Injection:
Taking Dabigatran etexilate with Ngmine 250 Injection can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Ngmine 250 Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Coadministration of Ngmine 250 Injection and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Ngmine 250 Injection and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
How does the drug interact with Ngmine 250 Injection:
Coadministration of Ngmine 250 Injection with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Ngmine 250 Injection and Fondaparinux, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ngmine 250 Injection:
Co-administration of Prasugrel with Ngmine 250 Injection can increase the risk of bleeding.

How to manage the interaction:
Although taking Prasugrel and Ngmine 250 Injection together can evidently cause an interaction, it can be taken if a doctor has suggested it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Using Dasatinib together with Ngmine 250 Injection may increase the risk of bleeding.

How to manage the interaction:
Although taking Ngmine 250 Injection and Dasatinib together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs: bruising, feeling dizzy or lightheaded, dark stools, headache, weakness, contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Taking cefdinir with Ngmine 250 Injection may increase the effects of Ngmine 250 Injection.

How to manage the interaction:
Although taking Cefdinir and Argatroban together can evidently cause an interaction, but it can be taken if prescribed by a doctor. In case you experience any side effects like chest tightness, shortness of breath, swelling of legs, or palpitations, consult a doctor. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Ngmine 250 Injection:
Co-administration of Ngmine 250 Injection and Rivaroxaban can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Ngmine 250 Injection and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ngmine 250 Injection:
Coadministration of Ngmine 250 Injection with Enoxaparin can increase the risk or severity of bleeding.

How to manage the interaction:
Co-administration of Ngmine 250 Injection with Enoxaparin can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like bleeding, bruising, dizziness, black or red stools, severe headache, weakness, or vomiting call a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, fruits, skinless poultry, fish, eggs, and low-fat dairy products.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Managing stress with meditation, yoga, and massage.
  • Avoid eating fried food, fast food, boxed food, canned food, and processed frozen meals.

Side Effects of Ngmine 250 Injection

  • Nose bleeds
  • Skin rash
  • Bleeding in bowels
  • Blood in urine
  • Low haemoglobin
  • Bruising
  • Thrombocytopenia

Habit Forming

No

Therapeutic Class

ANTICOAGULANTS / ANTITHROMBOTICS. ANTICONVULSANTS

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Ngmine 250 Injection works by inhibiting the clumping of platelets, thereby reducing the chance of blood clot formation. This helps in reducing the rate of cardiovascular events such as myocardial infarction (heart attack).

No, you are not recommended to take ibuprofen with Ngmine 250 Injection as co-administration of these two medicines may increase the risk of bleeding more easily. However, please consult a doctor before taking other medicines with Ngmine 250 Injection.

Ngmine 250 Injection may cause anaemia (low haemoglobin and low red blood cell count). So it would be best if you include iron-rich food in your diet to prevent anaemia.

Drug-Drug Interactions Checker List

  • IBUPROFEN
  • CELECOXIB
  • TRAMADOL
  • CLOPIDOGREL
  • ENOXAPARIN
  • PRASUGREL
  • TICAGRELOR

Special Advise

 Regular blood tests are advised while taking Ngmine 250 Injection to monitor prothrombin, platelets and coagulation time.

Disease/Condition Glossary

Blood clot: Platelets are small cell particles that circulate in the blood. When the blood vessel is damaged or cut, the platelets clump together and lead to the formation of a clot, preventing bleeding. The formation of clots in arteries can cut off the blood supply, leading to heart attack, stroke or death. Clot formation in the arteries that supply blood to the heart may cause reduced blood flow which could lead to unstable angina (chest pain).

Heart attack: It is a condition where a blood clot blocks a blood vessel supplying your heart, starving it of oxygen and causing chest pain and sometimes death. Quick medication is advised to reduce the risk of serious conditions due to blood clots.

Have a query?

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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption while receiving Ngmine 250 Injection to prevent unpleasant side effects.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Ngmine 250 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data are available on the effect of Ngmine 250 Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Ngmine 250 Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Ngmine 250 Injection does not affect your ability to drive.

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Liver

Caution

Ngmine 250 Injection should be used with caution in patients with liver impairment. Please inform your doctor if you have liver disease or any concerns regarding this.

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Kidney

Caution

Ngmine 250 Injection should be used with caution in patients with kidney impairment. Please inform your doctor if you have kidney disease or any concerns regarding this.

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Children

Unsafe

Ngmine 250 Injection is not recommended for use in children, as efficacy and safety have not been established.

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