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Written By Divya L , PharmaD
Reviewed By Sunny S , MBBS
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Synonym :

METFORMIN HYDROCHLORIDE+VOGLIBOSE

Manufacturer/Marketer :

Hiral Labs Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nirvog-M 0.3 mg Tablet

Nirvog-M 0.3 mg Tablet belongs to the class of anti-diabetic drugs. It is used in the treatment of type 2 diabetes mellitus. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all.

Nirvog-M 0.3 mg Tablet is composed of two medicines, namely Voglibose and Metformin. Voglibose belongs to the class of alpha-glucosidase inhibitors. It acts by inhibiting the intestinal enzymes, which break complex sugars into simple sugars such as glucose. This process prevents the rise of blood glucose levels. Metformin belongs to the class of biguanides and exhibits non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. Metformin is considered to be a unique anti-diabetic drug since it does not cause hypoglycemia (lowered blood sugar levels).

Take Nirvog-M 0.3 mg Tablet with food at regular intervals as prescribed by your doctor. Your doctor will decide the dosage form, and this may change timely depending on your blood sugar levels. The common side effects of Nirvog-M 0.3 mg Tablet include nausea, vomiting, changes in taste, diarrhoea, dizziness, stomach pain, shortness of breath, skin rash, bloating, and flatulence (intestinal wind/gas). Although not everyone experiences these side effects, if they occur, seek medical attention. Lactic acidosis, is a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation is reported. The risk of lactic acidosis is high in people with kidney, liver, and heart diseases.

Before starting Nirvog-M 0.3 mg Tablet , let your doctor know if you have any medical history of anaemia (low hemoglobin levels), seizures (fits), heart, kidney, and liver diseases. Nirvog-M 0.3 mg Tablet does not cause hypoglycemia (low blood sugar levels). However, when used with other diabetic drugs like insulin or sulfonylureas, it can lead to hypoglycemia. Also, speak to your doctor if you are on restricted food or fluid intake since Nirvog-M 0.3 mg Tablet causes dehydration, low blood sugar, and kidney damage. Do not take Nirvog-M 0.3 mg Tablet if you have gastrointestinal diseases like ulcerative colitis or Crohn’s disease. Do not take or stop Nirvog-M 0.3 mg Tablet , if the doctor did not advise you to do so.

Uses of Nirvog-M 0.3 mg Tablet

Type 2 Diabetes mellitus.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Take Nirvog-M 0.3 mg Tablet preferably with a meal, since it lowers the blood sugar levels and causes gastrointestinal side effects. Your doctor may start the course with a low dose and gradually maintain an effective dose to achieve the required blood glucose control.

Medicinal Benefits

Nirvog-M 0.3 mg Tablet is used to treat type 2 diabetes mellitus. It is a combination of Voglibose and Metformin. Voglibose belongs to the class of alpha-glucosidase inhibitors. It delays glucose absorption by inhibiting the intestinal enzymes, which break complex sugars into simple sugars such as glucose. This process prevents the rise of blood glucose levels immediately after meals. Metformin belongs to the class of biguanides. It shows the non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. It is considered to be a unique anti-diabetic drug since it does not lower blood sugar levels. Metformin does not cause weight gain in most cases.

Storage

Store in a cool and dry place away from sunlight
Side effects of Nirvog-M 0.3 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

Nirvog-M 0.3 mg Tablet may increase the risk of cardiovascular diseases and hypoglycemic conditions in renal and liver disease patients. It can cause pneumatosis intestinalis (gas-filled cysts on the bowel wall) when used along with other alpha-gastrointestinal drugs. It is advised to monitor the gastrointestinal side effects thoroughly to rule out the possibility of pneumatosis intestinalis. Nirvog-M 0.3 mg Tablet has an increased risk of lactic acidosis (a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation). The risk of lactic acidosis is high in older people with kidney, liver, and heart diseases. Hence, brief your medical history and take advice from your doctor before starting Nirvog-M 0.3 mg Tablet . Avoid consuming excessive alcohol as it can potentiate lactic acidosis.

Drug-Drug Interactions

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Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a fiber-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.
  • Eat at regular intervals
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Your doctor also guides you on how to notice and manage the early symptoms of high/low blood sugar levels.
  • Gastrointestinal side effects can be managed with simple modifications in your lifestyle. These include cutting down on sugars and fatty foods, and avoiding carbonated drinks and foods that cause gas.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

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Author Details

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Drug-Diseases Interactions

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FAQs

Nirvog-M 0.3 mg Tablet contains two antidiabetic drugs, namely: Voglibose and Metformin. Voglibose delays glucose absorption by inhibiting the intestinal enzymes, which break complex sugars into simple sugars such as glucose. Metformin works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines.

There is no evidence of Nirvog-M 0.3 mg Tablet , causing weight loss. However, high doses of medicine affect food absorption, thereby causing a weight loss. Consult your doctor before starting Nirvog-M 0.3 mg Tablet .

Nirvog-M 0.3 mg Tablet may increase the risk of low blood sugar levels, especially with alcohol intake, exercise more than usual, delay or missing snacks or meals. However, if you experience any signs of low blood pressure such as dizziness, nausea, light-headedness, dehydration or fainting, please consult a doctor.

You are not recommended to stop taking Nirvog-M 0.3 mg Tablet on your own as discontinuing Nirvog-M 0.3 mg Tablet suddenly may cause recurring symptoms or worsen the condition. However, if you experience any difficulty while taking Nirvog-M 0.3 mg Tablet , please consult your doctor so that alternative medicine may be prescribed.

Drug-Drug Interactions Checker List

  • SELEGILINE
  • PREDNISOLONE
  • PHENYLBUTAZONE
  • METOLAZONE
  • HYDROCHLOROTHIAZIDE
  • METOPROLOL
  • PROPRANOLOL
  • ISOCARBOXAZID
  • PHENELZINE
  • CHLOROTHIAZIDE

Special Advise

Regular blood tests are recommended while taking Nirvog-M 0.3 mg Tablet to monitor blood sugar levels.

Disease/Condition Glossary

Diabetes Mellitus type 2 is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, excessive insulin is produced but it fails to act on the organs of the body. Symptoms of type 2 diabetes include feeling exhausted all time, feeling thirsty, having blurry vision, and the urge to urinate (pee) more often. Complications of type 2 diabetes include skin infection, eye problems (retinopathy), nerve damage (neuropathy), delayed wound healing, diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke. Both low and high blood sugar levels can be dangerous and should be treated as soon as possible. Your H1bA1C below 5.7% is normal, 5.7-6.4% confirms the prediabetes stage, and 6.5% or greater states diabetes condition.

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