Nobel Plus Tablet 10's belongs to a class of medicines known as 'non-steroidal anti-inflammatory drugs (NSAIDs)', primarily indicated in the treatment of mild to moderate pain. Pain can be temporary (acute) or long-lasting (chronic) in nature. Nobel Plus Tablet 10's relieves symptoms of arthritis, dysmenorrhea (painful periods or menstrual cramps) and reduces fever. Acute pain is caused by damage to the tissues of the muscle, bone, or other organs for a short time. While, chronic pain lasts for a long duration and is caused due to pathologies like nerve damage, mild migraine, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction or injury.

Nobel Plus Tablet 10's is composed of two medicines: Nimesulide and Acetaminophen. Nimesulide is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Acetaminophen acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together it helps in reducing mild to moderate pain in a shorter duration.

Take Nobel Plus Tablet 10's as prescribed by your doctor. You are advised to take Nobel Plus Tablet 10's for as long as your doctor has prescribed it for you depending on your medical condition. Like all medicines, Nobel Plus Tablet 10's may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like chest tightness, breathing difficulties, fever, skin rashes, increased heart rate, and or in case of any signs of hypersensitivity.

Do not take Nobel Plus Tablet 10's if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Nobel Plus Tablet 10's may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects from taking this drug. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days. Nobel Plus Tablet 10's is usually safe to be taken in pregnancy and breastfeeding females, however, an individual should consult their doctor before taking it. Nobel Plus Tablet 10's is well tolerated by elderly persons.

Nobel Plus Tablet 10's is composed of nimesulide and acetaminophen, primarily used to treat mild to moderate pain. Nobel Plus Tablet 10's is prescribed mainly to treat pain and get relief from discomfort caused by conditions like mild migraine, tooth pain, arthritis, period pain, back pain, cold/ flu pain and other types of short-term pains. Acetaminophen has got the advantage of producing less gastric irritation compared to other painkillers like aspirin.

• Nausea
• Vomiting
• Stomach pain
• Diarrhoea
• Constipation
• Indigestion
• Headache

Please inform your doctor before starting Nobel Plus Tablet 10's if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in Nobel Plus Tablet 10's is known to affect fertility, so if you are planning for pregnancy contact doctor. Nobel Plus Tablet 10's should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take Nobel Plus Tablet 10's as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.

Drug-Drug Interaction: Nobel Plus Tablet 10's is shown to interact with various drugs. Some of them include lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, aspirin), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), immune system affecting medicine (cyclosporine) and antidepressants (duloxetine). These drugs may affect the working of Nobel Plus Tablet 10's and may alter its efficacy.

Drug-Food Interaction: Excessive intake of alcoholic beverages, caffeine-containing food or drinks like coffee, tea, chocolate and some fizzy drinks should be avoided while taking Nobel Plus Tablet 10's. Taking together may lead to drowsiness and dizziness and sleepiness.

Drug-Disease Interaction: Nobel Plus Tablet 10's should not recommend for people having bleeding disorders, like hemophilia, von Willebrand disease or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.

• LITHIUM
• METHOTREXATE
• WARFARIN
• ASPIRIN
• METOCLOPRAMIDE
• DOMPERIDONE
• FUROSEMIDE
• PREDNISONE
• CIPROFLOXACIN
• THEOPHYLLINE
• EPHEDRINE
• CYCLOSPORINE
• DULOXETINE

• Include more glucosamine, chondroitin sulfate, vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
• In chronic conditions of arthritis or joint pain, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize chemical cytokines, which ramp up inflammation.
• Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short duration of time. Long term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel at the back of your spine curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

Inform your doctor about any bleeding disorders as nimesulide in Nobel Plus Tablet 10's should be taken with care as it may interference in the functioning of platelets.

Pain can be short term (acute) or long term (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. At the same time, chronic pain lasts for longer duration, it is caused due to pathologies like nerve damage, migraine, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, Osteoarthritis is a degenerative disease that results in chronic pain in joints (especially the knee) and stiffness making daily tasks difficult.