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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
COD available

Online payment accepted

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Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Nolapse 400mg/80mg Tablet

Nolapse 400mg/80mg Tablet belongs to the group of medicines called ‘antibiotics’ used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Nolapse 400mg/80mg Tablet does not work against infections caused by the virus, including cold and flu. 

Nolapse 400mg/80mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Nolapse 400mg/80mg Tablet stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Your doctor will decide the dose and duration of Nolapse 400mg/80mg Tablet based on your condition and the severity of the infection. In some cases, you may experience certain common side-effects such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side-effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Before starting Nolapse 400mg/80mg Tablet, please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take Nolapse 400mg/80mg Tablet on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking Nolapse 400mg/80mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. Nolapse 400mg/80mg Tablet is not recommended for children below 12years.

Uses of Nolapse 400mg/80mg Tablet

Bacterial infections

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew the tablet/capsule. Syrup/Suspension/Drops: Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper; shake the pack well before each use.

Medicinal Benefits

Nolapse 400mg/80mg Tablet belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Nolapse 400mg/80mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, Nolapse 400mg/80mg Tablet kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. Nolapse 400mg/80mg Tablet is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

Storage

Keep Nolapse 400mg/80mg Tablet out of reach and sight of children.
Side effects of Nolapse 400mg/80mg Tablet
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Drug Warnings

Do not take Nolapse 400mg/80mg Tablet if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking Nolapse 400mg/80mg Tablet if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking Nolapse 400mg/80mg Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
sulfamethoxazoleClozapine
Severe

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
How does the drug interact with Nolapse 400mg/80mg Tablet:
Taking Nolapse 400mg/80mg Tablet with BCG vaccine can reduce the effectiveness of the BCG vaccine

How to manage the interaction:
Although there is an interaction between Nolapse 400mg/80mg Tablet and BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
sulfamethoxazoleClozapine
Severe
How does the drug interact with Nolapse 400mg/80mg Tablet:
The combined use of Nolapse 400mg/80mg Tablet and clozapine may increase the risk or severity of toxicity.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Nolapse 400mg/80mg Tablet, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Nolapse 400mg/80mg Tablet:
Enalapril combined with Nolapse 400mg/80mg Tablet can cause hyperkalemia by elevating blood potassium levels. In severe cases, hyperkalemia can induce muscle paralysis, renal damage, and cardiac problems. The risk is increased if you are elderly, dehydrated, or have a history of renal or cardiovascular disease.

How to manage the interaction:
Although taking Enalapril together with Nolapse 400mg/80mg Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
TrimethoprimRopivacaine
Severe
How does the drug interact with Nolapse 400mg/80mg Tablet:
Using ropivacaine with Nolapse 400mg/80mg Tablet can cause higher levels of Nolapse 400mg/80mg Tablet in the blood.

How to manage the interaction:
Although taking Ropivacaine and Nolapse 400mg/80mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion contact your doctor immediately. Do not stop using any medications without a doctor's advice.
TrimethoprimQuinidine
Severe
How does the drug interact with Nolapse 400mg/80mg Tablet:
Using Nolapse 400mg/80mg Tablet can cause higher levels of Quinidine in the blood which increases risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Nolapse 400mg/80mg Tablet and Quinidine, but it can be taken if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Nolapse 400mg/80mg Tablet:
Taking Potassium chloride with Nolapse 400mg/80mg Tablet may increase potassium levels in the blood. High potassium levels can cause hyperkalemia (a high level of the electrolyte potassium in the blood.).

How to manage the interaction:
Although there is a possible interaction between Nolapse 400mg/80mg Tablet and Potassium chloride, you can take these medicines together if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
TrimethoprimIvacaftor
Severe
How does the drug interact with Nolapse 400mg/80mg Tablet:
When Nolapse 400mg/80mg Tablet is taken with Ivacaftor, the amount of Nolapse 400mg/80mg Tablet in the blood increases.

How to manage the interaction:
Taking Nolapse 400mg/80mg Tablet with Ivacaftor together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting your doctor.
TrimethoprimPotassium iodide
Severe
How does the drug interact with Nolapse 400mg/80mg Tablet:
Taking Potassium Iodide with Nolapse 400mg/80mg Tablet can make high levels of potassium in the blood which can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and Nolapse 400mg/80mg Tablet, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nolapse 400mg/80mg Tablet:
Taking Nolapse 400mg/80mg Tablet with Benazepril can cause high levels of potassium in the blood.

How to manage the interaction:
Although there is an interaction between benazepril and Nolapse 400mg/80mg Tablet, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nolapse 400mg/80mg Tablet:
Taking Lidocaine with Nolapse 400mg/80mg Tablet may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Nolapse 400mg/80mg Tablet with Lidocaine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience, gray skin color, feeling sick, having a headache, feeling dizzy or lightheaded, feeling tired, having trouble breathing, a fast or irregular heartbeat, feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

Side Effects of Nolapse 400mg/80mg Tablet

  • High levels of potassium in the blood
  • Palpitations (abnormal heartbeats)
  • Thrush or candidiasis (fungal infection)
  • Headache
  • Nausea
  • Diarrhoea
  • Skin rashes

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Nolapse 400mg/80mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, Nolapse 400mg/80mg Tablet kills the bacteria and stops their growth. Thereby, helps to treat bacterial infections.

Nolapse 400mg/80mg Tablet causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Diarrhoea might be a side-effect of Nolapse 400mg/80mg Tablet. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking Nolapse 400mg/80mg Tablet and consult your doctor. Do not take anti-diarrheal medicine on your own.

It is recommended to complete the course of Nolapse 400mg/80mg Tablet even if you feel better as it is an antibiotic, and leaving it in between may lead to recurring infections. Continue taking Nolapse 400mg/80mg Tablet for as long as your doctor has prescribed to treat your condition effectually.

Do not take Nolapse 400mg/80mg Tablet on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections.

Nolapse 400mg/80mg Tablet may affect certain laboratory test results. Inform the person doing the tests that you are taking Nolapse 400mg/80mg Tablet.

Nolapse 400mg/80mg Tablet may cause high levels of potassium in the blood, which could lead to abnormal heartbeats (palpitations). Regular monitoring of potassium levels and heart rate is advised while taking Nolapse 400mg/80mg Tablet.

Drug-Drug Interactions Checker List

  • GLIBENCLAMIDE
  • AZITHROMYCIN
  • METRONIDAZOLE
  • ALBUTEROL
  • BENDROFLUMETHIAZIDE
  • GLICLAZIDE

Special Advise

  • Nolapse 400mg/80mg Tablet may affect certain laboratory test results such as blood tests. Inform the person doing the tests that you are taking Nolapse 400mg/80mg Tablet. 
  • Your doctor may advise you to get regular tests if you have kidney problems or if you have been prescribed Nolapse 400mg/80mg Tablet for a longer duration, to know if the medicine is working properly.

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. Infectious or harmful bacteria can make you sick and reproduce quickly in the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms include fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with a weak immune system or taking immunosuppressive medicine are more prone to bacterial infection.

Have a query?

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Alcohol

Unsafe

Avoid alcohol consumption while taking Nolapse 400mg/80mg Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

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Pregnancy

Caution

Please consult your doctor before taking Nolapse 400mg/80mg Tablet if you are pregnant. Your doctor will prescribe Nolapse 400mg/80mg Tablet only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding, your doctor will prescribe Nolapse 400mg/80mg Tablet only if the benefits outweigh the risks.

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Driving

Caution

It is unknown whether Nolapse 400mg/80mg Tablet affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed.

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Liver

Caution

Please consult your doctor before taking Nolapse 400mg/80mg Tablet if you have liver impairment/liver disease. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

Nolapse 400mg/80mg Tablet to be taken with caution, especially if you have a history of kidney impairment/kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Nolapse 400mg/80mg Tablet is not recommended for children below 12 years.

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