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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
COD available

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Whats That

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Composition :

TOFACITINIB-5MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Novanib-T 5 Tablet

Novanib-T 5 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
Novanib-T 5 Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Novanib-T 5 Tablet if you are pregnant or breastfeeding. Novanib-T 5 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Novanib-T 5 Tablet

Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Directions for Use

Swallow Novanib-T 5 Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Novanib-T 5 Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Novanib-T 5 Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. Novanib-T 5 Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

Storage

Store in a cool and dry place away from sunlight
Side effects of Novanib-T 5 Tablet
  • Practice good hygiene by washing hands frequently when touching any wounds.
  • Apply creams or lotions to the dry skin and moisturize it.
  • Wear the proper clothing and footwear when working outside.
  • Cover the wounds with bandage and change it daily.
  • Avoid baths at swimming pools, lakes and rivers.
  • Drink a lot of water to control diarrhoea and prevent dehydration.
  • Avoid spicy, fatty, or high-fiber foods that may irritate the colon.
  • Reduce stress through methods such as deep breathing or meditation.
  • Include probiotics or supplements containing live bacteria to maintain the health of the gut.
  • Quit smoking since smoking makes colitis symptoms worse.
  • See your doctor right away if you experience extreme inflammation, bleeding stools, or abdominal pain.
  • To promote overall health, drink plenty of water and consume hydrating foods like watermelon and leafy greens.
  • Support gut health with probiotic-rich foods such as yoghurt and sauerkraut.
  • Eat antioxidant-rich foods like berries and green tea, while limiting sugary drinks, alcohol, and processed foods.
  • Additionally, reduce stress through relaxation techniques like deep breathing and meditation.
Managing Medication-Triggered UTIs: A Comprehensive Approach:
  • Inform your doctor about the medication you're taking and the UTI symptoms you're experiencing.
  • Your doctor may adjust your medication regimen or consider alternative medications or dosages that may reduce the risk of UTIs.
  • Drink plenty of water (at least 8-10 glasses a day) to help flush out bacteria. Avoid sugary drinks and caffeine, which can exacerbate UTI symptoms.
  • Urinate when you feel the need rather than holding it in. This can help prevent bacterial growth and reduce the risk of UTIs.
  • Consider cranberry supplements: Cranberry supplements may help prevent UTIs by preventing bacterial adhesion.
  • Monitor UTI symptoms and report any changes to your doctor.
  • If antibiotics are prescribed, take them as directed and complete the full course.

Drug Warnings

Do not take Novanib-T 5 Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking Novanib-T 5 Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Novanib-T 5 Tablet . Novanib-T 5 Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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TofacitinibPaclitaxel
Severe
TofacitinibDaunorubicin
Severe

Drug-Drug Interactions

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TofacitinibPaclitaxel
Severe
How does the drug interact with Novanib-T 5 Tablet:
Taking Novanib-T 5 Tablet with Paclitaxel may increase the risk of infection.

How to manage the interaction:
Although taking Paclitaxel and Novanib-T 5 Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibDaunorubicin
Severe
How does the drug interact with Novanib-T 5 Tablet:
When Novanib-T 5 Tablet is taken with Daunorubicin, it may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Novanib-T 5 Tablet and Daunorubicin, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibVincristine
Severe
How does the drug interact with Novanib-T 5 Tablet:
Taking Novanib-T 5 Tablet with Vincristine may increase the risk of infection.

How to manage the interaction:
Co-administration of Vincristine with Novanib-T 5 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibChlorambucil
Severe
How does the drug interact with Novanib-T 5 Tablet:
Taking Novanib-T 5 Tablet with Chlorambucil may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Novanib-T 5 Tablet and Chlorambucil, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blo, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibItraconazole
Severe
How does the drug interact with Novanib-T 5 Tablet:
Taking Itraconazole with Novanib-T 5 Tablet may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Novanib-T 5 Tablet and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
TofacitinibSirolimus
Severe
How does the drug interact with Novanib-T 5 Tablet:
Coadministration of Novanib-T 5 Tablet with Sirolimus may increase the risk or severity of developing infection.

How to manage the interaction:
Although there is a possible interaction between Sirolimus and Novanib-T 5 Tablet, you can take these medicines together if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibGemcitabine
Severe
How does the drug interact with Novanib-T 5 Tablet:
Coadministration of Novanib-T 5 Tablet and Gemcitabine can lead to or increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Novanib-T 5 Tablet and Gemcitabine, but it can be taken if advised by a doctor. Contact your doctor immediately if you develop symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
TofacitinibCiclosporin
Severe
How does the drug interact with Novanib-T 5 Tablet:
Co-administration of Novanib-T 5 Tablet with cyclosporine may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Novanib-T 5 Tablet can be taken with ciclosporin if prescribed by the doctor. Consult the prescriber if you experience side effects such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without a doctor's advice.
TofacitinibRituximab
Severe
How does the drug interact with Novanib-T 5 Tablet:
Taking Rituximab and Novanib-T 5 Tablet may increase the risk infections.

How to manage the interaction:
Taking Novanib-T 5 Tablet with Rituximab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
TofacitinibFosamprenavir
Severe
How does the drug interact with Novanib-T 5 Tablet:
Co-administration of Novanib-T 5 Tablet with fosamprenavir may increase the blood levels of Novanib-T 5 Tablet which increases risk of side effects.

How to manage the interaction:
Although taking Novanib-T 5 Tablet and Fosamprenavir together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Novanib-T 5 Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Novanib-T 5 Tablet, as it can lead to an interaction.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Novanib-T 5 Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Novanib-T 5 Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of Novanib-T 5 Tablet . Consult your doctor before taking Novanib-T 5 Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of Novanib-T 5 Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

Novanib-T 5 Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting Novanib-T 5 Tablet if you are trying to become pregnant or if you have any concerns regarding this.

Novanib-T 5 Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • FLUCONAZOLE
  • KETOCONAZOLE
  • AZATHIOPRINE
  • MERCAPTOPURINE
  • CYCLOSPORINE
  • TACROLIMUS
  • PREDNISONE

Special Advise

  • Your doctor may advise you to get a blood test done before starting treatment with Novanib-T 5 Tablet , after 4-8weeks of treatment and then every three months to determine your blood cell count.
  • Your doctor might advise regular tests to determine blood cholesterol levels and liver functioning.
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties.
  • If you are a woman of child-bearing potential, use effective contraception during the treatment with Novanib-T 5 Tablet and for 4 weeks after discontinuation.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue) that leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function. 

Psoriatic arthritis: It is a type of inflammatory arthritis which occurs in patients with psoriasis. It could also occur in patients without psoriasis, particularly in those who have relatives with psoriasis. It affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

Ulcerative colitis: It is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever, and weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite or nausea. 

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