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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Synonym

DOXORUBICIN HYDROCHLORIDE

Composition

DOXORUBICIN-50MG

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Nudoxa 50Mg/ 25Ml Inj

Nudoxa 50Mg/ 25Ml Inj is an anti-cancer medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Nudoxa 50Mg/ 25Ml Inj is primarily used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast). It is also used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children).

Nudoxa 50Mg/ 25Ml Inj contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Nudoxa 50Mg/ 25Ml Inj may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Nudoxa 50Mg/ 25Ml Inj. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Nudoxa 50Mg/ 25Ml Inj should be avoided if you are allergic to it or any other components of this medicine. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression, and severe liver disease. Hence, if you have any such conditions, inform your doctor. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause adverse effects. Nudoxa 50Mg/ 25Ml Inj is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Nudoxa 50Mg/ 25Ml Inj

Breast Cancer

Directions for Use

A trained healthcare professional will administer Nudoxa 50Mg/ 25Ml Inj. Hence, do not self-administer.

Medicinal Benefits

Nudoxa 50Mg/ 25Ml Inj contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Nudoxa 50Mg/ 25Ml Inj is also used in the treatment of acute lymphoblastic leukaemia, acute myeloblastic leukaemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumour, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma, metastatic bronchogenic carcinoma

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nudoxa 50Mg/ 25Ml Inj

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection
  • Red discolouration of urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Weight gain

Drug Warnings

Nudoxa 50Mg/ 25Ml Inj should be avoided if you are allergic to it. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression and severe liver disease. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause serious adverse effects. Nudoxa 50Mg/ 25Ml Inj is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Do not stop receiving Nudoxa 50Mg/ 25Ml Inj without a doctor’s advice, as it can cause serious health conditions. Nudoxa 50Mg/ 25Ml Inj is known to cause secondary malignancies, tissue necrosis, cardiomyopathy and septic shock in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
DoxorubicinEtanercept
Severe

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Coadministration of Nudoxa 50Mg/ 25Ml Inj with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Nudoxa 50Mg/ 25Ml Inj is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxorubicinEtanercept
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
When Etanercept is used with Nudoxa 50Mg/ 25Ml Inj, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Nudoxa 50Mg/ 25Ml Inj can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
DoxorubicinBaricitinib
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Combining Nudoxa 50Mg/ 25Ml Inj with Baricitinib can increase the likelihood and seriousness of side effects.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Nudoxa 50Mg/ 25Ml Inj if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor.
DoxorubicinEfavirenz
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Taking Efavirenz and Nudoxa 50Mg/ 25Ml Inj can increase the risk or severity of irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Efavirenz and Nudoxa 50Mg/ 25Ml Inj together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxorubicinGatifloxacin
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Taking Gatifloxacin and Nudoxa 50Mg/ 25Ml Inj can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Nudoxa 50Mg/ 25Ml Inj together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxorubicinClozapine
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Taking Nudoxa 50Mg/ 25Ml Inj and clozapine may increase the risk of neutropenia.

How to manage the interaction:
Co-administration of Nudoxa 50Mg/ 25Ml Inj with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - like a severe infection, fever, diarrhea, sore throat, muscle pain, or difficulty breathing - it's important to call your doctor right away." Do not discontinue any medications without first consulting your doctor.
DoxorubicinAmisulpride
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Using Amisulpride together with Nudoxa 50Mg/ 25Ml Inj can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although taking Nudoxa 50Mg/ 25Ml Inj and Amisulpride together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like an irregular heart rhythm, sudden dizziness, or severe diarrhea, it's important to contact the doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinInfliximab
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Combining Infliximab with Nudoxa 50Mg/ 25Ml Inj can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Nudoxa 50Mg/ 25Ml Inj can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinBaricitinib
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Using baricitinib together with Nudoxa 50Mg/ 25Ml Inj may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Nudoxa 50Mg/ 25Ml Inj if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
DoxorubicinMoxifloxacin
Severe
How does the drug interact with Nudoxa 50Mg/ 25Ml Inj:
Using Moxifloxacin together with Nudoxa 50Mg/ 25Ml Inj can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Nudoxa 50Mg/ 25Ml Inj together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, or irregular heartbeat, contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Nudoxa 50Mg/ 25Ml Inj Substitute

Substitutes safety advice
  • ADRIAMYCIN INJECTION 50MG

    by Others

    800.10per tablet
  • ADRIM 50MG INJECTION

    by Others

    800.10per tablet
  • DOXUTEC 50MG INJECTION 25ML

    by Others

    33.30per tablet
  • Orcamycin 50Mg Injection

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    810.00per tablet
  • Zodox 50 Injection 1's

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    800.10per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • PHENYTOIN
  • PHENOBARBITAL
  • RIFAMPICIN
  • CLARITHROMYCIN
  • VORICONAZOLE
  • CYCLOSPORIN
  • BUPROPION
  • PAROXETINE
  • FLUOXETINE
  • DEXAMETHASONE
  • HALOPERIDOL

Special Advise

  • Avoid intercourse while on treatment with Nudoxa 50Mg/ 25Ml Inj.
  • Regular complete blood count monitoring is advised.  Also, monitoring of liver function is important while receiving Nudoxa 50Mg/ 25Ml Inj.
  • According to postmarketing reports, juvenile children receiving doxorubicin hydrochloride are at risk of developing late cardiovascular dysfunction. Risk factors include early age during treatment (particularly five years), large cumulative dosages, and receipt of multimodal modality therapy. All pediatric patients who have received doxorubicin hydrochloride should undergo long-term cardiovascular monitoring.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

Lymphoma: Lymphoma is a wide word for cancer that develops in lymph system cells. Hodgkin lymphoma and non-Hodgkin lymphoma (NHL) are the two most common kinds. Hodgkin lymphoma is frequently curable.

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