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Reviewed By Sunny S , MBBS
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Manufacturer/Marketer :

Stadchem Of India

Consume Type :

ORAL

Return Policy :

Not Returnable

About Oftop TZ Tablet

Oftop TZ Tablet is a combination of medicine called 'antibiotics' primarily used to treat various infections caused by bacteria & protozoans. Oftop TZ Tablet is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa. Examples of infection caused by protozoa include dysentery (inflammation of the colon) and malaria. 

Oftop TZ Tablet is a combination of two antibiotics: Ofloxacin and Tinidazole. Ofloxacin helps in treating and preventing a wide range of bacterial infections. It is bactericidal in nature, which means it works by killing bacteria that cause infections. It inhibits bacterial cells' process, ultimately destroying the bacteria, thereby preventing the further spread of the infection. Oftop TZ Tablet is a broad-spectrum antibiotic against most Gram-negative bacteria, many Gram-positive bacteria, and some anaerobes bacteria (that live without oxygen). On the other hand, Tinidazole kills parasites and anaerobic bacteria responsible for causing infections. It works by damaging their genetic material called DNA. 

Oftop TZ Tablet should be taken in the dose and duration your doctor advises. It is recommended to take it with food and be taken at a fixed time to achieve maximum effect. You may sometimes experience nausea, vomiting, stomach pain, loss of appetite, headache, etc. Most of these side effects of Oftop TZ Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Please consult your doctor immediately if you experience any allergic reaction symptoms such as rashes, itching, swelling, or shortness of breath.

Inform your doctor if you have any lung disease, muscle weakness (myasthenia gravis), sleeping disorder or difficulty sleeping (sleep apnoea), severe liver disease, or problem with alcohol or other prescription recreational drugs. Inform your doctor if you plan to get pregnant, are pregnant, or are breastfeeding. Use of Oftop TZ Tablet is associated with an increased risk of tendinitis and tendon (tough tissue that connects muscle to bone) rupture in all ages. People taking Oftop TZ Tablet who are over 60 years are at high risk, especially those taking anti-allergic medicines like corticosteroid drugs. Oftop TZ Tablet is contraindicated in people with kidney/heart diseases and those who have had lung transplants, should its use is not recommended.

Uses of Oftop TZ Tablet

Bacterial infections, Protozoal infections

Directions for Use

This medicine can be taken with or without food (excluding dairy products). Oftop TZ Tablet should not be used unless prescribed by a doctor. Always take this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. Tablet: Swallow the tablet with water; Do not chew or crush the medicine.Suspension: Shake the bottle well before each use. Take/administer the prescribed dose using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Oftop TZ Tablet contains antibiotic Ofloxacin and Tinidazole, which helps treat and prevent a wide range of bacterial infections caused by Gram-negative bacteria, Gram-positive bacteria and some anaerobic bacteria (that live without oxygen). It is bactericidal and works by killing bacteria that cause infections by preventing the formation of their cell wall required for living. It also inhibits the repairing of bacterial cells. Altogether it kills the bacteria. Oftop TZ Tablet has the advantage of good penetration in most deep tissues and body fluids. Hence, it is also suitable for the treatment of deep tissue and bone bacterial infections. 

Storage

Keep Oftop TZ Tablet out of the sight and reach of children.

Drug Warnings

Do not take Oftop TZ Tablet if you are allergic or have had a severe reaction to Ofloxacin or other quinolone or fluoroquinolone antibiotics such as Delafloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Ciprofloxacin. Taking Oftop TZ Tablet may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or having a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (an autoimmune condition of joints causing pain, swelling, and loss of function), seizures (fits), epilepsy or if you participate in regular physical activity. Taking Oftop TZ Tablet may worsen muscle weakness in people with myasthenia gravis (a nervous system disorder that causes muscle weakness) and cause severe difficulty breathing or death. Dairy products should be avoided along with Oftop TZ Tablet. And also, exposure to sunlight should be avoided while taking Oftop TZ Tablet as it may cause increased phototoxicity or photosensitivity. Patients with epilepsy and irregular heartbeat (QT prolongation) should tell their doctor before taking Oftop TZ Tablet. 

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Oftop TZ Tablet:
Coadministration of Oftop TZ Tablet with Cisapride can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Oftop TZ Tablet with Cisapride together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor. Note: Cisapride is no longer available on the market. Cisapride should only be taken if prescribed by a doctor and closely monitored.
How does the drug interact with Oftop TZ Tablet:
The combination of Amiodarone and Oftop TZ Tablet may significantly increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Amiodarone and Oftop TZ Tablet interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without consulting a doctor.
OfloxacinSaquinavir
Critical
How does the drug interact with Oftop TZ Tablet:
Coadministration of Oftop TZ Tablet with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Oftop TZ Tablet with Saquinavir together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Oftop TZ Tablet:
Coadministration of Oftop TZ Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Oftop TZ Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Oftop TZ Tablet:
Coadministration of Oftop TZ Tablet with Sotalol can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Oftop TZ Tablet with Sotalol together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor. Do not discontinue any medications without consulting a doctor.
OfloxacinBepridil
Critical
How does the drug interact with Oftop TZ Tablet:
Using bepridil together with Oftop TZ Tablet drugs can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Oftop TZ Tablet with Bepridil can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop using any medications without consulting a doctor.
How does the drug interact with Oftop TZ Tablet:
Coadministration of Oftop TZ Tablet with Disopyramide can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Oftop TZ Tablet with Disopyramide together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinMesoridazine
Critical
How does the drug interact with Oftop TZ Tablet:
Using Mesoridazine together with Oftop TZ Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Mesoridazine with Oftop TZ Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
How does the drug interact with Oftop TZ Tablet:
Coadministration of Oftop TZ Tablet with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Oftop TZ Tablet with Thioridazine together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinHalofantrine
Critical
How does the drug interact with Oftop TZ Tablet:
Using halofantrine together with Oftop TZ Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Oftop TZ Tablet with Halofantrine can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do not drink or eat many caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Oftop TZ Tablet may increase nervousness, sleeplessness and anxiety caused by caffeine.
  • Probiotics should be taken after taking the full course of Oftop TZ Tablet to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help restore the intestine's good bacteria. 
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. Make sure you drink plenty of water or other fluids daily while taking Oftop TZ Tablet.
  • Avoid alcoholic consumption with Oftop TZ Tablet as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Oftop TZ Tablet in fighting off infections.

Side Effects of Oftop TZ Tablet

  • Nausea
  • Vomiting
  • Headache
  • Headache
  • Metallic taste 
  • Stomach pain
  • Loss of appetite
  • Dryness in the mouth

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Not recommended. A patient with a transplanted kidney might be taking an immunosuppressive drug like cyclosporin which is contraindicated with Oftop TZ Tablet failing the efficacy of the Immnosuppresant drug. There are chances of rejection of the transplanted kidney in the patient and, hence, not recommended to take Oftop TZ Tablet without a doctor's consultation.

Do not consume alcohol or alcohol-based products while taking Oftop TZ Tablet and at least 3 days after your treatment commences. You may experience unpleasant side effects such as fast heartbeats, nausea, vomiting, sweating and tingling under your skin.

Yes, after taking Oftop TZ Tablet, you may have diarrhoea. Oftop TZ Tablet is an antibiotic that kills or prevents bacterial growth, so some good intestinal bacteria that aid digestion might also get killed. So, drink plenty of fluids and take probiotics to prevent excessive loss of fluids from the body (dehydration).

It is advised not to take Oftop TZ Tablet should not be taken along with dairy products as it might affect the absorption and efficacy of Oftop TZ Tablet. However, you can take it with a meal that includes these foods or drinks.

Oftop TZ Tablet makes your skin sensitive to sunlight, known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In case of emergency, you should always wear sunscreen before going out.

If you miss a dose of Oftop TZ Tablet, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

Take Oftop TZ Tablet either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product that has calcium/magnesium/aluminium/iron/zinc, antiulcer agent (sucralfate) or anti-HIV drug (didanosine).

No, Oftop TZ Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor

Oftop TZ Tablet contains lactose so tell your doctor if you are intolerant to some sugars.

It is advised to tell your doctor if you are already taking Warfarin before taking Oftop TZ Tablet as it can increase the time it takes for blood clotting.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • AZITHROMYCIN
  • METFORMIN
  • ZINC+MAGNESIUM+CALCIUM+PHOSPHORUS+CHOLECALCIFEROL
  • IBUPROFEN
  • SUCRALFATE
  • ERYTHROMYCIN
  • CLOZAPINE
  • DEXAMETHASONE
  • GLIPIZIDE

Special Advise

  • Tendon damage (especially to the Achilles tendon) can occur within 48 hours of starting Oftop TZ Tablet treatment, so at the first sign of tendinitis (like painful swelling or inflammation), immediately stop taking Oftop TZ Tablet and consult a doctor. The affected limbs should be appropriately treated (immobilization).
  • In rare cases, prolonged use of Oftop TZ Tablet may increase the sugar level to require regular blood sugar monitoring.
  • Oftop TZ Tablet may cause confusion and dizziness affecting the central nervous system, so if you experience any of these symptoms, immediately stop taking Oftop TZ Tablet and consult a doctor. 

Disease/Condition Glossary

A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our bodies. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms like fevers, chills, and fatigue. Bacteria are of various forms comprising, commonly spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. A few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can become infected with a bacterial infection. People with weak immune systems or taking immunosuppressive medicine can make them more prone to bacterial infection.

Pneumonia: In this type of infection, there is inflammation of the air sacs in one or both lungs. It can be caused by various organisms, including bacteria, viruses, and fungi.

Endocarditis: It is the infection of the inner lining of heart chambers and heart valves. It can occur when micro-organisms such as bacteria, fungi or other germs from other body parts, such as the mouth, spread through the bloodstream and get attached to damaged areas in the heart.

Septic arthritis: It is also known as joint infection or infectious arthritis. Joint inflammation is due to an infectious agent's invasion of a joint.

Osteomyelitis: It is an infection of the bone caused by staphylococcus bacteria that can be found in the nose or skin in healthy individuals.

Meningitis: It is inflammation of the meninges in which the membranes covering the brain and spinal cord get inflamed. It occurs due to infection, which bacteria or viruses can cause.

Dysentery: It is inflammation of the intestine, particularly the colon, caused by the bacteria Shigella.

Diarrhoea: It is a medical condition in which a person faces loose, watery stools loose or a frequent need to have a bowel movement.

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