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Written By Urvashi Bharti , MBBS
Reviewed By Hari Kumar , MBBS
Non returnable*
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Composition :

FLUOROURACIL-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About ONCOFLUOR 500MG INJECTION

ONCOFLUOR 500MG INJECTION belongs to a group of anti-cancer medicines called 'antimetabolites' used to treat breast, colon, rectum, pancreatic and stomach/gastric cancer. Cancer is a disease in which cells divide uncontrollably. Cancer can be localized (benign) or spread to the whole body (metastasized). 

ONCOFLUOR 500MG INJECTION contains 'Fluorouracil' that works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from multiplying and growing and eventually kills them.

In some cases, ONCOFLUOR 500MG INJECTION may cause nausea, vomiting, weakness, loss of appetite, increased risk of infection, hair loss, diarrhoea, decreased blood cells, and mouth ulcers. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Inform your doctor if you have a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency, heart problems, bone marrow depression, kidney disease, liver disease, or if you are on treatment with chemotherapy or radiation. Avoid taking ONCOFLUOR 500MG INJECTION if you are pregnant or breastfeeding. Both women and men on treatment with ONCOFLUOR 500MG INJECTION should use birth control to avoid pregnancy. 

Uses of ONCOFLUOR 500MG INJECTION

Breast, colon, rectum, pancreatic and stomach/gastric cancer

Directions for Use

It will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

ONCOFLUOR 500MG INJECTION belongs to a group of anti-cancer medicines called 'antimetabolites' used to treat breast, colon, rectum, pancreatic and stomach/gastric cancer. ONCOFLUOR 500MG INJECTION contains 'Fluorouracil' that works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from multiplying and growing and eventually kills them.

Storage

Store in a cool and dry place away from sunlight

Side Effects of ONCOFLUOR 500MG INJECTION

  • Nausea
  • Vomiting
  • Weakness
  • Loss of appetite
  • Increased risk of infection
  • Hair loss
  • Diarrhoea
  • Decreased blood cells 
  • Mouth ulcer

Drug Warnings

Inform your doctor if you have any infection, a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency, heart problems, bone marrow depression, kidney disease, liver disease, or if you are on treatment with chemotherapy or radiation. Consult your doctor if you are pregnant because ONCOFLUOR 500MG INJECTION can cause harmful effects on the unborn baby. Women and men using ONCOFLUOR 500MG INJECTION should use birth control to avoid pregnancy. The use of ONCOFLUOR 500MG INJECTION by either parent may result in congenital disabilities. ONCOFLUOR 500MG INJECTION should be used with caution in elderly patients. If you have had leukaemia (blood cancer) and are in remission, do not take live vaccines for three months after your last chemotherapy.

Drug-Drug Interactions

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FluorouracilThalidomide
Severe
FluorouracilWarfarin
Severe

Drug-Drug Interactions

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FluorouracilThalidomide
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Using thalidomide together with Oncofluor 500mg Injection 10ml can increase the risk of dangerous blood clots

How to manage the interaction:
Although there is a possible interaction between Thalidomide and Oncofluor 500mg Injection 10ml, but it can be taken together if prescribed by your doctor. However, consult a doctor immediately if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg Do not stop using any medications without a doctor's advice.
FluorouracilWarfarin
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Taking Warfarin together with Oncofluor 500mg Injection 10ml may increase the risk of bleeding.

How to manage the interaction:
Although taking Warfarin and Oncofluor 500mg Injection 10ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience symptoms such as unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not stop using any medications without consulting a doctor.
FluorouracilFolic acid
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Co-administration of Folic acid with Oncofluor 500mg Injection 10ml may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Folic acid and Oncofluor 500mg Injection 10ml, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FluorouracilCladribine
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Combining Cladribine with Oncofluor 500mg Injection 10ml can increase the risk of side effects.

How to manage the interaction:
Taking Cladribine with Oncofluor 500mg Injection 10ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
FluorouracilClozapine
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Co-administration of Oncofluor 500mg Injection 10ml with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
There may be a possibility of interaction between Oncofluor 500mg Injection 10ml and Clozapine, but it can be taken if prescribed by a doctor. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FluorouracilInfliximab
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Using Infliximab together with Oncofluor 500mg Injection 10ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab together with Oncofluor 500mg Injection 10ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FluorouracilTofacitinib
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Using tofacitinib together with Oncofluor 500mg Injection 10ml may increase the risk of serious infections.

How to manage the interaction:
Although there is a interaction between tofacitinib and Oncofluor 500mg Injection 10ml but can be taken if advised by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
FluorouracilFolic acid
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Coadministration of Folic acid and Oncofluor 500mg Injection 10ml may increase the effects of Oncofluor 500mg Injection 10ml and increase the risk of serious side effects such as bleeding problems, anaemia (lack of blood), infections, and nerve damage.

How to manage the interaction:
Although there is a possible interaction between Folic acid and Oncofluor 500mg Injection 10ml, you can take these medicines together if prescribed by your doctor. However, if you experience diarrhoea, paleness of skin, severe nausea and vomiting, over-tiredness, dizziness, fainting, blood in the stools, unusual bleeding or bruising, fever, chills, body pains, flu-like symptoms, skin reactions, mouth ulcers or sores, and/or numbness, burning or tingling in your hands and feet, contact your doctor.
FluorouracilMitomycin
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Taking Oncofluor 500mg Injection 10ml with mitomycin has been associated with a condition known as hemolytic uremic syndrome (HUS) and using it with Oncofluor 500mg Injection 10ml may increase that risk.

How to manage the interaction:
Although taking Mitomycin and Oncofluor 500mg Injection 10ml together can cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without first consulting a doctor.
FluorouracilThalidomide
Severe
How does the drug interact with Oncofluor 500mg Injection 10ml:
Taking thalidomide together with Oncofluor 500mg Injection 10ml may increase the risk of blood clots and that may lead to serious complications.

How to manage the interaction:
Although taking thalidomide and Oncofluor 500mg Injection 10ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.
  • Get optimal sleep, and rest well.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES

ONCOFLUOR 500MG INJECTION Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

ONCOFLUOR 500MG INJECTION works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Yes, ONCOFLUOR 500MG INJECTION affects the hair by making it thin, which further causes hair loss. However, it is not very common. Hair reduction possibly happens due to the estrogen-lowering effect of ONCOFLUOR 500MG INJECTION. These effects are not long-lasting and may return after some time. If it matters to you, then consult your doctor for further advice.

Yes, ONCOFLUOR 500MG INJECTION may change the results of blood tests and other laboratory tests. Inform the person doing the tests that you are taking ONCOFLUOR 500MG INJECTION.

$nanme might affect fertility (ability to have children) in both men and women. You may not be able to become pregnant or father a child after treatment with ONCOFLUOR 500MG INJECTION. However, it is essential to talk to your doctor before starting treatment with ONCOFLUOR 500MG INJECTION if you think you may want to have a baby in the future.

Drug-Drug Interactions Checker List

  • METHOTREXATE
  • CISPLATIN
  • CYTARABINE
  • MITOMYCIN
  • TAMOXIFEN
  • METRONIDAZOLE
  • ALLOPURINOL
  • CIMETIDINE
  • WARFARIN
  • INTERFERON ALFA
  • PHENYTOIN
  • RUBELLA (LIVE ATTENUATED)
  • MUMPS (LIVE ATTENUATED)
  • MEASLES (LIVE ATTENUATED)
  • BACILLUS CALMETTE-GUERIN(BCG) VACCINE
  • SHINGLES VACCINE
  • CALCIUM LEUCOVORIN
  • BRIVUDINE
  • SORIVUDINE

Special Advise

  • Your doctor may suggest routine blood tests to monitor your liver function, electrolyte levels, and blood cell count.
  • Consult a doctor immediately if you notice any signs of infection, fever, diarrhoea, chills, etc.
  • Women of childbearing potential and men with partners of childbearing potential must use an effective method of contraception while on treatment with ONCOFLUOR 500MG INJECTION and for at least three months afterwards. Please consult your doctor for any concerns regarding this.

Disease/Condition Glossary

Breast cancer: It is a type of cancer that develops in breast cells stimulated by a female sex hormone called oestrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and travel to lymph nodes, a primary pathway for the cancer cells to move to other body parts. Symptoms of breast cancer include a lump in the breast or tissue thickening, which feels different than the normal surrounding tissues, breast pain, redness, swelling, and nipple discharge other than breast milk.

Stomach Cancer (gastric cancer): It is a type of cancer that develops from the stomach lining. Risk factors may include smoking, a highly processed or salty diet, and severe bacterial infection of H. pylori.  Symptoms of stomach cancer include feeling bloated after eating, feeling full after eating small amounts of food, nausea, heartburn or indigestion.

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