Open UP 150 Tablet 10's

Open UP 150 Tablet 10's belongs to a group of medicines called the biliary agents or gall stone dissolution agents used to treat gall stones, primary biliary cholangitis (an autoimmune disease of the liver), excess cholesterol in bile and children above 6years with biliary and liver diseases caused by cystic fibrosis. 

Open UP 150 Tablet 10's contains ursodeoxycholic acid, which is a naturally-occurring bile acid. Open UP 150 Tablet 10's helps decrease the production of cholesterol in the blood, thereby dissolving gall bladder stones composed mainly of cholesterol. Open UP 150 Tablet 10's has a protective effect on the liver cells from injury caused due to toxic bile acids and improves liver function.

Take Open UP 150 Tablet 10's with food. You are advised to take Open UP 150 Tablet 10's for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as abdominal discomfort, abdominal pain, diarrhoea, nausea, rash, dizziness, indigestion and weakness. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Inform your doctor before taking Open UP 150 Tablet 10's if you have variceal bleeding (high blood pressure in portal veins), ascites (excess abdominal fluid), liver encephalopathy or liver disease. Do not take Open UP 150 Tablet 10's if you are pregnant or breastfeeding unless prescribed. Open UP 150 Tablet 10's can be given to children above 6 years if prescribed by the doctor. Avoid consuming alcohol along with Open UP 150 Tablet 10's as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Open UP 150 Tablet 10's contains ursodeoxycholic acid, which is a naturally-occurring bile acid. It belongs to a group of medicines called the biliary agent or gall stone dissolution agents used to treat gall stones, primary biliary cholangitis (an autoimmune disease of the liver), excess cholesterol in bile children above 6 years with biliary and liver diseases caused by cystic fibrosis. Open UP 150 Tablet 10's breaks down the cholesterol that has formed into gall bladder stones, thereby dissolves the stones. Open UP 150 Tablet 10's has a protective effect on the liver cells and the immune system, thereby improving liver function. Open UP 150 Tablet 10's decreases the amount of cholesterol produced by the liver and absorbed by the intestine. In patients with primary biliary cirrhosis, Open UP 150 Tablet 10's increases the bile flow.

• Abdominal discomfort
• Abdominal pain
• Diarrhoea
• Nausea
• Fever
• Cough
• Rash
• Dizziness
• Indigestion
• Black or tarry stools
• Frequent and painful urination
• Weakness

Do not take Open UP 150 Tablet 10's if you are allergic to any of its contents, if you have inflammation of gall bladder and bile ducts, narrowing or blockage bile ducts, biliary colic, calcified gallstones, improper constriction of the gallbladder, gastric or duodenal ulcer. Inform your doctor before taking Open UP 150 Tablet 10's if you have variceal bleeding (high blood pressure in portal veins), ascites (excess abdominal fluid), liver encephalopathy or liver disease. Consult your doctor before taking Open UP 150 Tablet 10's with other medicines as Open UP 150 Tablet 10's might reduce the absorption of antibiotics (ciprofloxacin and dapsone) and antihypertensive agents (nitrendipine), increase the effect of immunosuppressants (cyclosporine), oral contraceptives (oestrogen) and cholesterol-lowering agents (clofibrate) might promote the formation of gallstones. Do not take Open UP 150 Tablet 10's if you are pregnant or breastfeeding unless prescribed. Open UP 150 Tablet 10's can be given to children above 6 years if prescribed by the doctor. Avoid consuming alcohol along with Open UP 150 Tablet 10's as it could lead to increased drowsiness and liver damage. Keep your doctor informed about your health condition and medicines to rule out any unpleasant side-effects.

Drug-Drug Interactions: Open UP 150 Tablet 10's may have interaction with antibiotics (ciprofloxacin and dapsone), antihypertensive agents (nitrendipine), immunosuppressants (cyclosporine), hormone (oestrogen), antacids (aluminium hydroxide, aluminium carbonate, magaldrate).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have biliary obstruction and liver impairment, variceal bleeding (high blood pressure in portal veins), ascites (excess abdominal fluid), or liver encephalopathy.

• CIPROFLOXACIN
• DAPSONE
• CYCLOSPORINE
• ESTROGEN
• ALUMINUM HYDROXIDE
• ALUMINUM CARBONATE
• NITRENDIPINE
• MAGALDRATE

• Include foods such as bell peppers, citrus fruits, leafy vegetables, tomatoes, milk, fish, low-fat dairy, beans, nuts, lentils, tofu and tempeh in your diet.
• Eat a healthy, well-balanced diet which includes fruits and vegetables.
• Foods rich in Vitamin B, C and calcium, are good for gallbladder.
• Plant-based protein foods such as beans, nuts, lentils, tofu and tempeh help prevent gallbladder disease.
• Avoid high-fat, trans-fat and processed foods.
• White bread, white pasta and sugars should be avoided.
• Avoid tobacco and alcohol consumption.

• Your doctor may advice regular liver function test to monitor the function of the liver and the progress of the treatment.
• Open UP 150 Tablet 10's may rarely cause thinning and loss of hair, if there is excessive loss of hair consult your doctor for further advice.

Primary biliary cholangitis: Primary biliary cholangitis, formerly known as primary biliary cirrhosis, is an autoimmune disease caused by bile ducts damage in the liver. Bile ducts are the small channels which carry the bile (digestive fluid) from the liver to small intestine where it breaks down fats and aids in its absorption. Biliary cirrhosis causes a build-up of bile in the liver, which leads to liver damage.
Gallbladder stones: Gallbladder is a small organ located below the liver which stores bile, which helps with digestion. Excess cholesterol in bile leads to the formation of gallstones. Gallstones can cause pain in the abdomen, dark urine and stools, indigestion, diarrhoea, nausea and vomiting.
Cystic fibrosis: It is a hereditary disease that affects the digestive system and lungs. In this condition, the body produces a thick and sticky fluid that obstructs the pancreas and clogs the lungs.