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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
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About Ornicip 500mg/500mg Tablet

Ornicip 500mg/500mg Tablet is a combination of antibiotics primarily used to treat or prevent certain infections caused by bacteria and parasites (amoeba). It is prescribed for the treatment of diarrhoea. Additionally, it also treats vaginal and other bacterial infections. A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our bodies. It can target any body part and multiple very quickly. Amoebic dysentery can be caused due to Entamoeba histolytica, Giardia lamblia, or Clostridium difficile.

Ornicip 500mg/500mg Tablet contains Ciprofloxacin and Ornidazole. Ciprofloxacin is a fluoroquinolone that helps treat and prevent many bacterial infections. It is bactericidal and works by killing bacteria that cause infections. It prevents the division of bacterial cells. It also inhibits the repairing of bacterial cells. Ornidazole’ kills the harmful bacteria and parasites (amoeba) by damaging its DNA and preventing these bacteria growth from spreading hence relieving the symptoms. Altogether it kills the bacteria. Ornicip 500mg/500mg Tablet does not treat a viral infection like the flu or a common cold.

Ornicip 500mg/500mg Tablet should be taken in the dose and duration your doctor advises. You are advised to take Ornicip 500mg/500mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Sometimes, you may experience common side effects such as nausea, vomiting, headache, weakness, dizziness, dry mouth, and metallic taste. Most of these side effects of Ornicip 500mg/500mg Tablet do not require medical attention and gradually resolve over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please tell your doctor if you are allergic to Ornicip 500mg/500mg Tablet or any other medicines. If you are pregnant or breastfeeding, please inform your doctor before using Ornicip 500mg/500mg Tablet. Ornicip 500mg/500mg Tablet should not be used in children unless prescribed by a doctor.  It is not advisable to suddenly stop this medicine to avoid unpleasant side effects and sudden withdrawal symptoms. Inform your doctor if you have any lung disease, muscle weakness (myasthenia gravis), sleeping disorder, difficulty sleeping (sleep apnoea), or severe liver disease. Do not drive or operate heavy machinery after taking Ornicip 500mg/500mg Tablet as it may cause dizziness, drowsiness, and make you less alert. You should not take any alcoholic beverages during your treatment as they can cause flushing and a general feeling of being unwell.

Uses of Ornicip 500mg/500mg Tablet

Bacterial Infections, Diahorrea due to Entamoeba histolytica, Giardia lamblia, Vaginal bacterial or protozoal infections, Dental infections, Post-surgery infections

Directions for Use

Tablet: Take this medicine with or without food. It should be swallowed as a whole with water; do not chew, break, or crush the tablet.

Medicinal Benefits

Ornicip 500mg/500mg Tablet contains a combination of antibiotics, namely; Ciprofloxacin and Ornidazole, primarily used to treat bacterial/parasitic infections. Ciprofloxacin is a class of fluoroquinolones that helps treat and prevent a wide range of bacterial infections. It is bactericidal and works by killing bacteria that cause infections. It prevents the division of bacterial cells and inhibits the repairing of bacterial cells. Both these actions lead to the killing of the bacteria. Ornidazole; being bactericidal, kills harmful bacteria by damaging their DNA and preventing these bacteria growth from spreading hence relieving the symptoms. Ornicip 500mg/500mg Tablet is two times more active than other nitroimidazoles, like metronidazole, against amoebiasis and giardiasis and anaerobes. Together, Ornicip 500mg/500mg Tablet is used to effectively treat patients with certain vaginal, urinary, or intestinal infections.

Storage

Keep Ornicip 500mg/500mg Tablet out of the sight and reach of children.
Side effects of Ornicip 500mg/500mg Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.

Drug Warnings

Do not take Ornicip 500mg/500mg Tablet if you are allergic or have had a severe reaction to ciprofloxacin, ornidazole, or any other quinolone or fluoroquinolone and anti-amoebic agents. Let your doctor know if you use any prescription and non-prescription medications you are taking, including vitamins, and herbal supplements, before starting Ornicip 500mg/500mg Tablet. Do not take Ornicip 500mg/500mg Tablet on your own, as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Taking Ornicip 500mg/500mg Tablet may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or having a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (an autoimmune disorder of joints causing pain, swelling, and loss of function), seizures (fits), epilepsy or if you participate in regular physical activity.  Dairy products should be avoided along with Ornicip 500mg/500mg Tablet. And also, exposure to sunlight should be avoided while taking Ornicip 500mg/500mg Tablet as it may cause increased phototoxicity or photosensitivity. Patients with epilepsy and irregular heartbeat (especially a condition known as QT prolongation) should tell their doctor before taking Ornicip 500mg/500mg Tablet.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Ornicip 500mg/500mg Tablet:
When Ornicip 500mg/500mg Tablet is taken with Pimozide, it can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Ornicip 500mg/500mg Tablet with Pimozide is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Ornicip 500mg/500mg Tablet:
Coadministration of sotalol together with Ornicip 500mg/500mg Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Sotalol with Ornicip 500mg/500mg Tablet is generally avoided as it can result in an interaction, it can be taken together if prescribed by a doctor. However, consult the doctor if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ornicip 500mg/500mg Tablet:
Using Ornicip 500mg/500mg Tablet with Cisapride can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Ornicip 500mg/500mg Tablet with Cisapride is not recommended, it can be take if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
CiprofloxacinQuinidine
Critical
How does the drug interact with Ornicip 500mg/500mg Tablet:
When Ornicip 500mg/500mg Tablet is taken with Quinidine, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ornicip 500mg/500mg Tablet with Quinidine is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Ornicip 500mg/500mg Tablet:
Taking Amiodarone and Ornicip 500mg/500mg Tablet may significantly increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Amiodarone with Ornicip 500mg/500mg Tablet is not recommended, it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ornicip 500mg/500mg Tablet:
When Dronedarone is taken with Ornicip 500mg/500mg Tablet, it can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Ornicip 500mg/500mg Tablet with Dronedarone is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
CiprofloxacinFlibanserin
Critical
How does the drug interact with Ornicip 500mg/500mg Tablet:
When Flibanserin is taken with Ornicip 500mg/500mg Tablet, it can cause extreme drowsiness and reduces blood pressure that can lead to dizziness, lightheadedness, fainting.

How to manage the interaction:
Taking Ornicip 500mg/500mg Tablet with Flibanserin is not recommended, but it can be taken if prescribed by the doctor. It is advised to take flibanserin at bedtime to reduce the risk of side effects
How does the drug interact with Ornicip 500mg/500mg Tablet:
Coadministration of Ornicip 500mg/500mg Tablet and Tizanidine together can increase the risk of side effects.

How to manage the interaction:
Using Ornicip 500mg/500mg Tablet and Tizanidine together is avoided, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, weakness, sweating, or palpitations contact the doctor immediately. Do not discontinue any medications without consulting the doctor.
How does the drug interact with Ornicip 500mg/500mg Tablet:
Coadministration of Ornicip 500mg/500mg Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ornicip 500mg/500mg Tablet with Ziprasidone is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, confusion, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
CiprofloxacinHalofantrine
Critical
How does the drug interact with Ornicip 500mg/500mg Tablet:
Using Ornicip 500mg/500mg Tablet with Halofantrine can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Ornicip 500mg/500mg Tablet with Halofantrine is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.

Drug-Food Interactions

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CIPROFLOXACIN-500MG+ORNIDAZOLE-500MGCalcium rich foods, Caffeine containing foods/drinks
Moderate

Drug-Food Interactions

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CIPROFLOXACIN-500MG+ORNIDAZOLE-500MGCalcium rich foods, Caffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Tofu Set With Calcium, Ragi, Seasame Seeds, Kale, Milk, Almonds, Bok Choy, Calcium-Fortified Soy Milk, Cheese, Yogurt, Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Using caffeine together with ciprofloxacin may increase the effects of caffeine. Taking dairy products such as milk, yogurt, or calcium-fortified foods can make the medication less effective. Avoid taking caffeine with ciprofloxacin, as it causes effects. Contact your doctor if you experience headaches, tremors, restlessness, nervousness, insomnia, and increased blood pressure or heart rate. Avoid taking milk, yogurt, or calcium-fortified foods. You could interrupt the feeding for 1 hour before and 2 hours after the ciprofloxacin dose. Do not stop using any medications without talking to your doctor

Diet & Lifestyle Advise

  • Probiotics should be taken after taking the full course of Ornicip 500mg/500mg Tablet to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut, kombucha, and kimchi can help to restore the good bacteria of the intestine. 
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. 
  • Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola, or chocolate. Ornicip 500mg/500mg Tablet may increase nervousness, sleeplessness, and anxiety caused by caffeine.
  • Avoid intake of alcoholic beverages with Ornicip 500mg/500mg Tablet as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Ornicip 500mg/500mg Tablet in fighting off infections.

Side Effects of Ornicip 500mg/500mg Tablet

  • Nausea
  • Vomiting
  • Stomach pain
  • Loss of appetite
  • Dizziness
  • Headache
  • Dryness in mouth

Habit Forming

No

Therapeutic Class

ANTIBIOTICS/ANTIMICROBIALS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Ornicip 500mg/500mg Tablet contains Ciprofloxacin and Ornidazole. Ciprofloxacin works by preventing the bacterial cells from dividing and repairing, thereby killing the bacteria. Ornidazole kills parasites and anaerobic bacteria that cause infections by damaging their DNA. Together, they treat bacterial and parasite (amoeba) infections effectively.

No, Ornicip 500mg/500mg Tablet should not be taken along with dairy products as it might affect the absorption and efficacy of Ornicip 500mg/500mg Tablet. However, you can take it with a meal with these foods or drinks.

Do not stop taking Ornicip 500mg/500mg Tablet even if you feel better without consulting your doctor. Your symptoms might improve with time, but it is advised to complete the full course of treatment.

Ornicip 500mg/500mg Tablet makes your skin sensitive to sunlight, known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In case of emergency, you should always wear sunscreen before going out.

No, Ornicip 500mg/500mg Tablet should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.

Drug-Drug Interactions Checker List

  • WARFARIN
  • DICUMAROL
  • DISULFIRAM
  • CLONAZEPAM
  • OLANZAPINE
  • INSULIN
  • CHLORPROPAMIDE
  • GLIMEPIRIDE
  • GLIPIZIDE
  • GLYBURIDE
  • TOLAZAMIDE
  • TOLBUTAMIDE
  • AMIODARONE
  • DISOPYRAMIDE
  • PROCAINAMIDE
  • QUINIDINE
  • IBUPROFEN
  • NAPROXEN

Special Advise

  • Do not stop taking the tablets your infection may come back. Talk to your doctor before you stop taking the tablets and follow their advice.

Disease/Condition Glossary

Bacterial infection: A bacterial infection is when harmful bacteria enter, multiply, and infect our body. It can target any body part and multiple very quickly. When you get infected with bacteria, you can experience generalized symptoms like fevers, chills, and fatigue. Bacteria are of various forms comprising, commonly spherical, rod, and spiral-shaped. Bacterial infections vary from minor illnesses like sore throat and ear infections to severe brain infections like meningitis and encephalitis. A few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine can make you more prone to bacterial infection.

Amoebic dysentery: It is an intestinal (bowel) illness caused by a parasite (amoeba) known as Entamoeba histolytica spread through human faeces (poop). Usually, there are no symptoms, but sometimes, it causes diarrhoea (loose stool/poop), nausea (a feeling of sickness in the stomach), and weight loss.

Have a query?

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Alcohol

Caution

It is not recommended to consume alcohol while taking Ornicip 500mg/500mg Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Ornicip 500mg/500mg Tablet is a pregnancy Category C medicine. It is not known whether Ornicip 500mg/500mg Tablet will affect pregnant women or foetus or not. Hence, the intake of Ornicip 500mg/500mg Tablet should be avoided if you are pregnant or planning to become pregnant, as it may harm the baby.

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Breast Feeding

Caution

Ornicip 500mg/500mg Tablet is excreted in human milk. But the amount of Ornicip 500mg/500mg Tablet absorbed by the nursing infant is unknown. So, should not be taken while breastfeeding.

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Driving

Unsafe

Ornicip 500mg/500mg Tablet can affect alertness and coordination. So, driving and operating machinery which requires concentration should be avoided.

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Liver

Caution

Ornicip 500mg/500mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose based on your condition.

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Kidney

Caution

Ornicip 500mg/500mg Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust the dose based on your condition.

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Children

Caution

Ornicip 500mg/500mg Tablet should not be used in children unless prescribed by a doctor.

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