Paleno 125 mg Capsule 21's belongs to the group of anti-cancer drugs used to treat certain types of breast cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body. Breast cancer is cancer that forms in the cells of the breast. It can form in the lobules, ducts or tubules of the breast or in the breast tissue itself.

Paleno 125 mg Capsule 21's contains Palbociclib that works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Paleno 125 mg Capsule 21's is effective in controlling cancer cells from multiplying and is used in the treatment of breast cancer. 

Take Paleno 125 mg Capsule 21's as prescribed. In some cases, Paleno 125 mg Capsule 21's may cause certain common side effects such as weakness, loss of appetite, infections and dry skin. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist or worsen. 

It is advisable to inform the doctor if you are allergic to any of its components. Do not take Paleno 125 mg Capsule 21's if you are pregnant or breastfeeding. Paleno 125 mg Capsule 21's may cause tiredness, so drive only if you are alert. Paleno 125 mg Capsule 21's is not recommended for use in children below 18years. Keep your doctor informed about your health condition and medications to rule out any interactions.

Paleno 125 mg Capsule 21's is an anti-cancer drug used in the treatment of a particular type of breast cancer that is hormone receptor-positive and human epidermal growth factor receptor-2-negative. Paleno 125 mg Capsule 21's works by blocking the production of proteins called cyclin-dependent kinase 4 and 6 that are responsible for cell growth and division. By blocking them, Paleno 125 mg Capsule 21's nips cell growth in the bud and prevents cancer cells from spreading further. Thus, Paleno 125 mg Capsule 21's helps treat breast cancer.

• Loss of appetite
• Dry skin
• Weakness
• Infection
• Hair loss
• Fever
• Inflammation of the mouth and lips

Do not take St. John's wort or grapefruit/grapefruit juice with Paleno 125 mg Capsule 21's. It is advisable to inform the doctor if you are allergic to any of its components. Do not take Paleno 125 mg Capsule 21's if you are pregnant or breastfeeding. Paleno 125 mg Capsule 21's may cause tiredness, so drive only if you are alert. Paleno 125 mg Capsule 21's is not recommended for use in children below 18years. If you experience any signs or symptoms of infections, inform your doctor. Keep your doctor informed about your health condition and medications to rule out any interactions. Consult your doctor immediately if you experience symptoms such as dry cough, chest pain, difficulty breathing or shortness of breath as it could be an indication of lung inflammation

Drug-DrugInteractions: Paleno 125 mg Capsule 21's may interact antiviral/anti-HIV drug (lopinavir, ritonavir, nelfinavir, telaprevir, saquinavir), antidepressant (St John’s wort and nefazodone), antifungals (voriconazole, itraconazole, ketoconazole, posaconazole), antibiotics (clarithromycin, telithromycin) anti-rheumatoid drug (abatacept), heart medicine (quinidine), anti-gout medicine (colchicine), anaesthetics (alfentanyl and fentanyl), immunosuppressants (tacrolimus, cyclosporine), antipsychotics (pimozide) and anti-migraine drugs (dihydroergotamine, ergotamine).

Drug-Food Interactions: Paleno 125 mg Capsule 21's may interact with grapefruit and grapefruit juice.

Drug-Disease Interactions: Paleno 125 mg Capsule 21's should be used with caution in patients with a known hypersensitivity disorder, HIV, epilepsy, lactose intolerance, kidney disease, liver disease, lung or breathing disorders, hypertension, diabetes, heart disease, gout or a disease of the veins.

• RITONAVIR
• NELFINAVIR
• SAQUINAVIR
• LOPINAVIR
• TELAPREVIR
• ITRACONAZOLE
• KETOCONAZOLE
• VORICONAZOLE
• POSACONAZOLE
• CLARITHROMYCIN
• TELITHROMYCIN
• ABATACEPT
• QUINIDINE
• COLCHICINE
• ALFENTANIL
• FENTANYL
• TACROLIMUS
• CYCLOSPORINE
• PIMOZIDE
• ERGOTAMINE

• Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
• Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
• Stay hydrated by drinking plenty of water as dehydration is often seen in cancers.
• Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
• Avoid smoking and alcohol consumption.

• Discuss contraception with your doctor while taking Paleno 125 mg Capsule 21's.
• People on treatment with Paleno 125 mg Capsule 21's should use additional contraception (barrier method such as condoms). Contraception should be continued 3 weeks post-treatment for women and 14 weeks post-treatment for men.
• You may want to consider sperm storage before starting Paleno 125 mg Capsule 21's. Seek counsel on the same from a qualified healthcare individual and/or sperm bank. 
• Regular complete blood count monitoring is advised.

Breast Cancer: Breast cancer is a type of cancer that develops in breast cells. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and can travel to lymph nodes which are a primary pathway for the cancer cells to move to other parts of the body. Symptoms of breast cancer include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin, and a lump or swelling under the arm.