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Written By Divya L , PharmaD
Reviewed By Santoshini Reddy G , M Pharmacy
Non returnable*
COD available

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Composition :

PANTOPRAZOLE-40MG

Manufacturer/Marketer :

Orley Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About PC-40 Injection

PC-40 Injection is a proton pump inhibitor, primarily used to treat gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis (acid-related damage to the oesophagus lining), Zollinger-Ellison syndrome and other conditions caused due to excessive acid in the stomach. GERD is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). Zollinger Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers.

PC-40 Injection contains Pantoprazole. It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. 

PC-40 Injection will be administered by a healthcare professional. Common side effects of PC-40 Injection include headache, dizziness, diarrhoea, nausea, vomiting, stomach pain, gas, joint pain, pain, redness, and swelling at the injection site. These side effects may not occur in every patient using this medication and differ individually. If the side effects persist longer or worsen, please seek a doctor's advice.

Let your doctor know if you are sensitive or allergic to PC-40 Injection or other medications. Before using PC-40 Injection, let your doctor know if you have any liver, kidney or heart diseases and gastrointestinal problems. Pregnant and breastfeeding women should consult their doctor before using PC-40 Injection. PC-40 Injection may cause dizziness; hence drive or operate machinery only when you are alert. Avoid alcohol intake while using PC-40 Injection since it can increase acid production in the stomach. PC-40 Injection is not recommended for children below five years of age.

Uses of PC-40 Injection

Stomach ulcers, gastro-oesophageal reflux disease (GERD), heartburn, erosive oesophagitis, and Zollinger-Ellison syndrome.

Directions for Use

PC-40 Injection will be injected by a healthcare professional. Do not self-administer.

Medicinal Benefits

PC-40 Injection contains Pantoprazole, which is a proton pump inhibitor. It blocks the action of the gastric proton pump that is responsible for the production of acid in the stomach. This reduces the amount of acid produced, heals the ulcers, and prevents the formation of new ulcers. It also relieves the symptoms of GERD like heartburn, difficulty in swallowing, and persistent cough. Pantoprazole may also prevent oesophageal cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of PC-40 Injection

  • Headache
  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhoea
  • Stomach pain
  • Gas
  • Joint pain
  • Pain, redness, and swelling at the injection site.

Drug Warnings

Let your doctor know if you are sensitive to any of the components in PC-40 Injection. PC-40 Injection should be used with caution and only under a doctor’s supervision if you have stomach/intestinal problems, liver, kidney or heart diseases, recent abdominal surgery, risk of bone fractures, and autoimmune diseases like lupus. Long term treatment with PC-40 Injection may increase the risk of fractures of the hip, spine, and wrist. Hence, inform your doctor if you have osteoporosis and bone-related problems. PC-40 Injection may also cause low Vitamin B12 levels on long term usage. Hence let your doctor know if you have Vitamin B12 deficiency before starting PC-40 Injection. Let your doctor know if you are pregnant or a nursing mother before starting PC-40 Injection. PC-40 Injection may cause dizziness; hence drive or operate machinery only when you are alert. Avoid alcohol intake while using PC-40 Injection since it can increase acid production in the stomach. PC-40 Injection is recommended for children above five years of age only when prescribed by a doctor.

Drug-Drug Interactions

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PantoprazoleRilpivirine
Critical
PantoprazoleDasatinib
Severe

Drug-Drug Interactions

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PantoprazoleRilpivirine
Critical
How does the drug interact with PC-40 Injection:
Co-administration of Rilpivirine is taken with PC-40 Injection, can decrease the absorption and blood levels of Rilpivirine and make the medication less effective.

How to manage the interaction:
Taking PC-40 Injection with Rilpivirine can lead to an interaction, please consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
PantoprazoleDasatinib
Severe
How does the drug interact with PC-40 Injection:
Taking Dasatinib with PC-40 Injection may decrease the blood levels of Dasatinib and reduce its effectiveness.

How to manage the interaction:
Taking PC-40 Injection with Dasatinib together can result in an interaction, but it can be taken if a doctor has advised it. In case of any unusual side effects, contact a doctor. Do not stop using any medications without a doctor's advice.
PantoprazoleMethotrexate
Severe
How does the drug interact with PC-40 Injection:
Co-administration of Methotrexate with PC-40 Injection can increase the levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between PC-40 Injection and methotrexate, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, or dizziness, consult a doctor. Do not stop using any medications without consulting a doctor.
PantoprazolePazopanib
Severe
How does the drug interact with PC-40 Injection:
Taking PC-40 Injection with Pazopanib may reduce the effectiveness of pazopanib.

How to manage the interaction:
If you are supposed to take PC-40 Injection and Pazopanib together, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PantoprazoleErlotinib
Severe
How does the drug interact with PC-40 Injection:
Taking Erlotinib with PC-40 Injection may interfere with the absorption of Erlotinib into the bloodstream, and reduce its effectiveness.

How to manage the interaction:
Taking PC-40 Injection with Erlotinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
PantoprazoleDacomitinib
Severe
How does the drug interact with PC-40 Injection:
Taking PC-40 Injection can make Dacomitinib less effective by reducing its absorption in the body.

How to manage the interaction:
Taking PC-40 Injection with Dacomitinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
PantoprazoleNelfinavir
Severe
How does the drug interact with PC-40 Injection:
Taking Nelfinavir with PC-40 Injection may decrease the absorption and blood levels of Nelfinavir and reduce its effectiveness.

How to manage the interaction:
Taking PC-40 Injection with Nelfinavir together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.
PantoprazoleGefitinib
Severe
How does the drug interact with PC-40 Injection:
Taking Gefitinib with PC-40 Injection reduces the acidity level in the stomach and may interfere with the absorption of Gefitinib and reduce its effectiveness.

How to manage the interaction:
Taking PC-40 Injection with Gefitinib together can possibly result in an interaction, it can be taken if your doctor has advised it. You are recommended to take gefitinib 12 hours before or 12 hours after PC-40 Injection to help minimize the impact of the interaction. Do not discontinue the medication without consulting a doctor.
PantoprazoleAtazanavir
Severe
How does the drug interact with PC-40 Injection:
Co-administration of PC-40 Injection reduces stomach acid, decreases the absorption and blood levels of Atazanavir, and reduces its effectiveness.

How to manage the interaction:
Taking PC-40 Injection with Atazanavir together can possibly result in an interaction, but it can be taken if a doctor has advised it. A doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Manage stress, eat healthily, drink plenty of water, exercise regularly, and get plenty of sleep.
  • Limit taking high fibre foods, foods and drinks that contain chocolate, alcohol, caffeine, fructose, or sorbitol, carbonated drinks, fried, and fatty foods. 
  • Do not have large meals at a time; instead try having small and simpler meals at regular intervals, including fresh fruits and vegetables in your diet.
  • Practice yoga and recreation techniques to manage your emotional stress.
  • If you are lactose intolerant, avoid using dairy products since it can worsen your stomach discomfort.
  • If you cannot take dairy products, it is advised to include other calcium-rich foods like leafy greens, beans, nuts, and seeds.
  • Drink plenty of fluids to prevent dehydration.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS

PC-40 Injection Substitute

Substitutes safety advice
  • Nicopenta 40 Tablet 10's

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    15.15per tablet
  • Pantocid Tablet 15's

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    11.65per tablet
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    11.33per tablet
  • PAN 40 Tablet 15's

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    10.20per tablet
  • Pantodac 40 mg Tablet 15's

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    14.37per tablet

Author Details

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Drug-Diseases Interactions

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PANTOPRAZOLE-40MGOther bacterial intestinal infections
Severe

Drug-Diseases Interactions

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PANTOPRAZOLE-40MGOther bacterial intestinal infections
Severe
How does the disease interact with PC-40 Injection:
Use of proton pump inhibitors, particularly in hospitalised patients, may increase the incidence of Clostridium difficile-associated diarrhoea. Monitor closely. Prefer lower dose of PPI for short duration.

How to manage the interaction:
The doctor may recommend the lowest dose and shortest duration of PC-40 Injection in hospitalized patients. Close monitoring is recommended in patients with diarrhoea and in those taking antibacterial agents.

FAQs

PC-40 Injection works by reducing the amount of acid produced in the stomach and thus relieves stomach ulcers, heartburn, GERD, and other gastrointestinal discomforts.

PC-40 Injection should be used with caution and only under a doctor’s supervision if you have any liver, kidney or heart diseases, stomach and intestinal problems, recent abdominal surgery, Vitamin B12 deficiency, risk of bone fractures, osteoporosis, and autoimmune diseases like lupus.

Please do not take PC-40 Injection for longer durations unless prescribed by the doctor. Taking PC-40 Injection on long-term may cause you to develop stomach growths known as fundic gland polyps. A regular check-up is advised if PC-40 Injection is prescribed for longer durations.

PC-40 Injection may cause bloating as a side effect with its regular use. You may experience tightness, fullness, or swelling of your stomach area. It is advised to avoid consuming wind/gas-producing foods like beans, onions, lactose-containing foods, and carbonated beverages. You can also try herbal teas like peppermint, coriander, fennel, turmeric, and chamomile. If you do not notice any improvement in your bloating, please seek medical advice.

Diarrhoea might be a side-effect of PC-40 Injection. Drink lots of fluids and eat non-spicy foods if you experience diarrhoea. If you find blood in stools (tarry stools) or experience excess diarrhoea, consult your doctor. Prolonged intake of proton pump inhibitors like PC-40 Injection is linked with a greater risk of Clostridium difficile-associated diarrhoea. If you develop diarrhoea that does not improve, immediately consult a doctor.

On long term treatment, PC-40 Injection may increase the risk of fractures of the hip, spine, and wrist. Inform your doctor if you have osteoporosis, bone-related problems, or take any corticosteroids. Your doctor may suggest supplements like Calcium citrate and Vitamin D.

PC-40 Injection may cause low Vitamin B12 levels on long term usage. Your doctor may adjust the dose of PC-40 Injection accordingly and may suggest Vitamin B12 supplements if you are on long term treatment with PC-40 Injection.

Drug-Drug Interactions Checker List

  • ATAZANAVIR
  • KETOCONAZOLE
  • ITRACONAZOLE
  • METHOTREXATE
  • DIGOXIN

Special Advise

  • Your doctor may suggest diagnostic procedures like endoscopy or colonoscopy to understand your condition and its severity.
  • PC-40 Injection may interfere with urine tests for tetrahydrocannabinol-THC and blood tests to find certain tumours. Inform your doctor and laboratory staff that you are taking PC-40 Injection before undergoing examinations.

Disease/Condition Glossary

Acidity: The stomach is usually protected from the acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like acidity, GERD, heartburn, stomach ulcer, and Zollinger Ellison syndrome.

Gastroesophageal reflux disease (GERD): It is a condition that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. Symptoms of GERD include chest pain, difficulty swallowing, regurgitation (expulsion of food from the pharynx or oesophagus) of food/sour liquid, and a burning sensation in the chest.

Zollinger Ellison syndrome: It is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production leading to peptic ulcers. Symptoms include abdominal pain, diarrhoea, heartburn, acid reflux, and burping.

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