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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Synonym :

DOXORUBICIN HYDROCHLORIDE

Composition :

DOXORUBICIN-2MG/ML

Manufacturer/Marketer :

Zee Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Peg Doxozest 50 Injection 25 ml

Peg Doxozest 50 Injection 25 ml is an anti-cancer medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Peg Doxozest 50 Injection 25 ml is primarily used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast). It is also used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children).

Peg Doxozest 50 Injection 25 ml contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Peg Doxozest 50 Injection 25 ml may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Peg Doxozest 50 Injection 25 ml. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Peg Doxozest 50 Injection 25 ml should be avoided if you are allergic to it or any other components of this medicine. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression, and severe liver disease. Hence, if you have any such conditions, inform your doctor. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause adverse effects. Peg Doxozest 50 Injection 25 ml is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Peg Doxozest 50 Injection 25 ml

Breast Cancer

Directions for Use

A trained healthcare professional will administer Peg Doxozest 50 Injection 25 ml. Hence, do not self-administer.

Medicinal Benefits

Peg Doxozest 50 Injection 25 ml contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Peg Doxozest 50 Injection 25 ml is also used in the treatment of acute lymphoblastic leukaemia, acute myeloblastic leukaemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumour, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma, metastatic bronchogenic carcinoma

Storage

Store in a cool and dry place away from sunlight

Side Effects of Peg Doxozest 50 Injection 25 ml

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection
  • Red discolouration of urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Weight gain

Drug Warnings

Peg Doxozest 50 Injection 25 ml should be avoided if you are allergic to it. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression and severe liver disease. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause serious adverse effects. Peg Doxozest 50 Injection 25 ml is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Do not stop receiving Peg Doxozest 50 Injection 25 ml without a doctor’s advice, as it can cause serious health conditions. Peg Doxozest 50 Injection 25 ml is known to cause secondary malignancies, tissue necrosis, cardiomyopathy and septic shock in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Peg Doxozest 50 Injection 25 ml Substitute

Substitutes safety advice
  • Adriamycin Ready-To-Use 50 mg Injection 25 ml

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  • Adripeg 20 Injection 10 ml

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  • Adripeg 50 Injection 25 ml

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  • Peg Doxozest 20 mg Injection 10 ml

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    980.00per tablet

FAQs

Peg Doxozest 50 Injection 25 ml contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Peg Doxozest 50 Injection 25 ml can disrupt a woman's natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with Peg Doxozest 50 Injection 25 ml.

Drug-Drug Interactions Checker List

  • PHENYTOIN
  • PHENOBARBITAL
  • RIFAMPICIN
  • CLARITHROMYCIN
  • VORICONAZOLE
  • CYCLOSPORIN
  • BUPROPION
  • PAROXETINE
  • FLUOXETINE
  • DEXAMETHASONE
  • HALOPERIDOL

Special Advise

  • Avoid intercourse while on treatment with Peg Doxozest 50 Injection 25 ml.
  • Regular complete blood count monitoring is advised.  Also, monitoring of liver function is important while receiving Peg Doxozest 50 Injection 25 ml.
  • According to postmarketing reports, juvenile children receiving doxorubicin hydrochloride are at risk of developing late cardiovascular dysfunction. Risk factors include early age during treatment (particularly five years), large cumulative dosages, and receipt of multimodal modality therapy. All pediatric patients who have received doxorubicin hydrochloride should undergo long-term cardiovascular monitoring.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

Lymphoma: Lymphoma is a wide word for cancer that develops in lymph system cells. Hodgkin lymphoma and non-Hodgkin lymphoma (NHL) are the two most common kinds. Hodgkin lymphoma is frequently curable.

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