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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Pemshil 500Mg Injection

Pemshil 500Mg Injection belongs to the group of medicines called folate analogue metabolic inhibitors used alone or in combination with other anti-cancer medicines to treat non-small cell lung cancer and malignant pleural mesothelioma (cancer affecting the lining of the lung). 
 
Pemshil 500Mg Injection contains Pemetrexed, which works by blocking the action of substances that may help the cancer cells multiply.
 
In some cases, Pemshil 500Mg Injection may cause side effects such as diarrhoea, tiredness, nausea, vomiting, and loss of appetite. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not use Pemshil 500Mg Injection if you are pregnant or breastfeeding. Pemshil 500Mg Injection is not recommended for children below 18 years. Women and men should use effective contraception during treatment with Pemshil 500Mg Injection and for 6 and 3 months afterwards. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

PEMETREXED-500MG

Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Pemshil 500Mg Injection

Non-small cell lung cancer, malignant pleural mesothelioma.

Medicinal Benefits

Pemshil 500Mg Injection contains Pemetrexed, which belongs to the group of medicines called anti-folate anti-neoplastic agents indicated in the treatment of malignant pleural mesothelioma and non-small cell lung cancer in initial treatment in combination with cisplatin, as maintenance treatment of patients whose disease has not progressed after four cycles of platinum-based first-line chemotherapy and after prior chemotherapy as a single agent. Pemshil 500Mg Injection treats cancer by blocking the action of substances that may help the cancer cells multiply.

Side Effects of Pemshil 500Mg Injection

  • Nausea
  • Vomiting
  • Loss of appetite
  • Tiredness
  • Pain, redness, swelling or sores in the mouth
  • Infection
  • Sore throat
  • Low white blood cells, haemoglobin levels
  • Skin rash
  • Flaking skin

Directions for Use

Pemshil 500Mg Injection will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use Pemshil 500Mg Injection if you are allergic to any of its components, pregnant or breastfeeding, or if you have taken or plan to receive yellow fever vaccination. Inform the doctor if you have/had heart disease, kidney problems, have had or are going to have radiation therapy, or have accumulation of fluid around the lungs. Seek immediate medical attention if you experience symptoms of fever or infection; pain, sores, redness or swelling in the mouth; chest pain or a fast heartbeat; allergic reaction (skin rash, burning/prickling sensation, or fever); Stevens-Johnson Syndrome or toxic epidermal necrolysis (severe rash, itching, or blistering); low haemoglobin levels (tiredness, feeling faint, paleness, or becoming easily breathless); low platelet count (bleeding from gums/nose/mouth, bleeding that does not stop, unexpected bruising, reddish or pinkish urine); or blood clot in the blood vessels of the lungs (sudden breathlessness, cough with bloody sputum or intense chest pain).

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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PemetrexedCladribine
Severe
PemetrexedThalidomide
Severe

Drug-Drug Interactions

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PemetrexedCladribine
Severe
How does the drug interact with Pemshil 500Mg Injection:
Taking Cladribine with Pemshil 500Mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Cladribine and Pemshil 500Mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PemetrexedThalidomide
Severe
How does the drug interact with Pemshil 500Mg Injection:
Taking thalidomide together with Pemshil 500Mg Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Pemshil 500Mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
PemetrexedEtanercept
Severe
How does the drug interact with Pemshil 500Mg Injection:
When Etanercept is used with Pemshil 500Mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Pemshil 500Mg Injection and Etanercept together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
PemetrexedClozapine
Severe
How does the drug interact with Pemshil 500Mg Injection:
Combining Pemshil 500Mg Injection with Clozapine can increase the risk of infection.

How to manage the interaction:
Co-administration of Pemshil 500Mg Injection with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
PemetrexedBaricitinib
Severe
How does the drug interact with Pemshil 500Mg Injection:
Coadministration of Pemshil 500Mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Pemshil 500Mg Injection and Baricitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
PemetrexedInfliximab
Severe
How does the drug interact with Pemshil 500Mg Injection:
When Pemshil 500Mg Injection is taken with Infliximab, it can enhance the metabolism of Pemshil 500Mg Injection. This can reduce the treatment outcome and can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Pemshil 500Mg Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PemetrexedMeloxicam
Severe
How does the drug interact with Pemshil 500Mg Injection:
Co-administration of Meloxicam and Pemshil 500Mg Injection together may increase the levels of Pemshil 500Mg Injection in the blood.

How to manage the interaction:
Co-administration of Meloxicam with Pemshil 500Mg Injection can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice symptoms like fever, chills, flu-like symptoms, mouth sores, severe diarrhea, or any injuries, call a doctor right away. Do not discontinue any medications without consulting a doctor.
PemetrexedTofacitinib
Severe
How does the drug interact with Pemshil 500Mg Injection:
Taking Tofacitinib with Pemshil 500Mg Injection may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Pemshil 500Mg Injection and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried, processed food, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Special Advise

  • The doctor may advise blood tests to evaluate your liver/kidney function and blood cell count.
  • Women must use effective contraception during treatment and for six months after receiving the last dose.
  • Men are advised to use effective contraception during treatment and for three months after the end of the treatment. 
  • You are recommended to take the supplements as advised by the doctor.

Disease/Condition Glossary

Non-small cell lung cancer: It is a disease in which cancer cells form in the tissues of the lungs. The major risk factor for non-small cell lung cancer is smoking. Symptoms include a cough that does not go away and shortness of breath.

Malignant pleural mesothelioma: It is a type of cancer that develops in the mesothelium (a lining that covers the outer surface of organs), predominantly caused by exposure to asbestos. Symptoms of mesothelioma in the lining of the lungs include chest pain, shortness of breath, extreme tiredness, persistent cough, loss of appetite, unexplained weight loss, fever and sweating, particularly at night.

Pemshil 500Mg Injection Substitute

Substitutes safety advice
  • PEMMET 500MG INJECTION

    4931.50per tablet
  • ALIMTA INJECTION 500MG

    24600.00per tablet
  • Pemotide 500 Injection 1's

    5559.60per tablet
  • Pemeena 500mg Injection 1's

    5387.40per tablet
  • Relitrexed-500 Injection 1's

    7212.30per tablet
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