Perindosyl-Am 4/5Mg Tablet 10'S belongs to the class of 'anti-hypertensive drugs', primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition, in which the blood exerts high pressure (force exerted by circulating blood) against blood vessel's walls. This condition makes the heart work harder in pumping the blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure.

Perindosyl-Am 4/5Mg Tablet 10'S is a combination of medicine that consists of Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine belongs to the class of 'calcium channel blockers' and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain) and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. It also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. On the other hand, Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, it reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. Thus, collectively, both help lower high blood pressure, reducing heart attack or stroke chances. 

Take Perindosyl-Am 4/5Mg Tablet 10'S as prescribed by your doctor. You are advised to take Perindosyl-Am 4/5Mg Tablet 10'S for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, the increased potassium level in the blood, cough, flushing (sense of heat in the face, ears, neck, and trunk), Taste change, decreased blood pressure, and upset stomach.

Do not stop taking Perindosyl-Am 4/5Mg Tablet 10'S without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. If you have angioedema (Painless swelling under the skin), diabetes then inform your doctor immediately. If you have kidney disease, you may not use Perindosyl-Am 4/5Mg Tablet 10'S with aliskiren (other blood pressure-lowering pills). Reducing the amount of table salt (sodium chloride) in your food. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, and high potassium level in your blood. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet 10'S can be prescribed accordingly.

Perindosyl-Am 4/5Mg Tablet 10'S treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. It also treats chest pain by improving blood supply to the heart muscle to receive more oxygen. Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels. On the other hand, Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, it reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. However, Perindosyl-Am 4/5Mg Tablet 10'S does not cure high blood pressure (hypertension) but does help control it. In addition to this, Perindosyl-Am 4/5Mg Tablet 10'S also reduces the physical effects of anxiety.

• Ankle swelling
• Tiredness
• Headache
• Dizziness
• Palpitations (irregular heartbeat)
• Sleepiness
• Increased potassium level in the blood
• Cough
• Flushing (sense of heat in the face, ears, neck, and trunk)
• Taste change
• Decreased blood pressure
• Upset stomach.

Do not stop taking Perindosyl-Am 4/5Mg Tablet 10'S without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. If you have angioedema (Painless swelling under the skin), diabetes then inform your doctor immediately. If you have kidney disease, you may not use Perindosyl-Am 4/5Mg Tablet 10'S with aliskiren (other blood pressure-lowering pills). Reducing the amount of table salt (sodium chloride) in your food.  Avoid potassium, containing food. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, diabetes, and high potassium level in your blood. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet 10'S can be prescribed accordingly.

Drug-Drug Interactions: Care should be exercised when Perindosyl-Am 4/5Mg Tablet 10'S is administered in combination with medications used for depression (lithium), medications used in cancer (estramustine), diuretics/ water pills (spironolactone, triamterene), medicines for reducing immune system (cyclosporine), blood pressure-lowering pills (aliskiren), medications for diabetes (insulin, vildagliptin), drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone) and medication for gout (allopurinol).

Drug-Food Interactions: Avoid taking a high potassium diet and drinking alcohol.

Drug-Disease Interactions: People affected with heart disease, liver disease, kidney disease, fluid retention should not take this Perindosyl-Am 4/5Mg Tablet 10'S.

• LITHIUM
• ESTRAMUSTINE
• SPIRONOLACTONE
• TRIAMTERENE
• CYCLOSPORINE

• Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
• Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
• If you are taking alcohol, use only one serving for women and two servings for men.
• Quit smoking to lower the risk of heart diseases.
• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
• Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
• Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
• Perindosyl-Am 4/5Mg Tablet 10'S may affect patients with hepatic impairment, and hence it is used cautiously, and Liver function monitoring and Liver Function Tests are advised to monitor the liver enzyme changes.
• Your doctor may advise you to get a regular kidney function test, blood examinations for potassium levels and other electrolytes while using Perindosyl-Am 4/5Mg Tablet 10'S to rule out any renal impairment.
• Do not take this medicine within 36 hours before or after taking medicine that contains sacubitril (antihypertensive drug).

Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower, and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke), and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg, and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nosebleed, vomiting, and chest pain.