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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Manufacturer/Marketer :

Elder Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Perindosyl-Am 4/5Mg Tablet

Perindosyl-Am 4/5Mg Tablet belongs to the class of 'anti-hypertensive drugs', primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition, in which the blood exerts high pressure (force exerted by circulating blood) against blood vessel's walls. This condition makes the heart work harder in pumping the blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure.

Perindosyl-Am 4/5Mg Tablet is a combination of medicine that consists of Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine belongs to the class of 'calcium channel blockers' and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain) and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. It also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. On the other hand, Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, it reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. Thus, collectively, both help lower high blood pressure, reducing heart attack or stroke chances. 

Take Perindosyl-Am 4/5Mg Tablet as prescribed by your doctor. You are advised to take Perindosyl-Am 4/5Mg Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. You may experience ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, the increased potassium level in the blood, cough, flushing (sense of heat in the face, ears, neck, and trunk), Taste change, decreased blood pressure, and upset stomach.

Do not stop taking Perindosyl-Am 4/5Mg Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. If you have angioedema (Painless swelling under the skin), diabetes then inform your doctor immediately. If you have kidney disease, you may not use Perindosyl-Am 4/5Mg Tablet with aliskiren (other blood pressure-lowering pills). Reducing the amount of table salt (sodium chloride) in your food. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, and high potassium level in your blood. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet can be prescribed accordingly.

Uses of Perindosyl-Am 4/5Mg Tablet

Hypertension (high blood pressure)

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Perindosyl-Am 4/5Mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. It also treats chest pain by improving blood supply to the heart muscle to receive more oxygen. Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels. On the other hand, Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, it reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. However, Perindosyl-Am 4/5Mg Tablet does not cure high blood pressure (hypertension) but does help control it. In addition to this, Perindosyl-Am 4/5Mg Tablet also reduces the physical effects of anxiety.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not stop taking Perindosyl-Am 4/5Mg Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. If you have angioedema (Painless swelling under the skin), diabetes then inform your doctor immediately. If you have kidney disease, you may not use Perindosyl-Am 4/5Mg Tablet with aliskiren (other blood pressure-lowering pills). Reducing the amount of table salt (sodium chloride) in your food.  Avoid potassium, containing food. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, diabetes, and high potassium level in your blood. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet can be prescribed accordingly.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Combining Aliskiren with Perindosyl-Am 4/5Mg Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet and carbamazepine together may significantly reduce Perindosyl-Am 4/5Mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Although there is an interaction between Perindosyl-Am 4/5Mg Tablet with carbamazepine, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Taking simvastatin with Perindosyl-Am 4/5Mg Tablet may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Perindosyl-Am 4/5Mg Tablet with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet and rifampicin together may lower Perindosyl-Am 4/5Mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Perindosyl-Am 4/5Mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AmlodipineDolasetron
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using dolasetron together with Perindosyl-Am 4/5Mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Perindosyl-Am 4/5Mg Tablet and Dolasetron, but it can be taken if prescribed by a doctor. If you have any of these symptoms, like feeling dizzy, lightheaded, or your heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Co-administration of Perindosyl-Am 4/5Mg Tablet can make Sirolimus may increase the risk of angioedema (a condition associated with swelling of the face, eyes, lips, tongue, throat, and occasionally also the hands and feet).

How to manage the interaction:
There may be a possibility of interaction between Perindosyl-Am 4/5Mg Tablet and Sirolimus, but it can be taken if prescribed by a doctor. However, consult the doctor if you notice any swelling of the face, eyes, lips, tongue, throat, hands and feet or have trouble breathing or swallowing. Do not stop using any medications without a doctor's advice.
AmlodipineIdelalisib
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet and Idelalisib may raise Perindosyl-Am 4/5Mg Tablet levels in the blood this may lead to serious side effects (irregular heart rhythm, fluid retention, swelling, heart failure, and abnormally low blood pressure).

How to manage the interaction:
Although taking Perindosyl-Am 4/5Mg Tablet with idelalisib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness or fainting, sudden, unexplained weight gain, swelling of the hands, ankles, or feet, chest discomfort, or trouble breathing while taking these drugs, consult the doctor. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not stop using any medications without a doctor's advice.
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet and phenytoin together may drastically lower Perindosyl-Am 4/5Mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although Perindosyl-Am 4/5Mg Tablet with phenytoin can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineFosphenytoin
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
When Perindosyl-Am 4/5Mg Tablet is taken with Fosphenytoin, it may decrease the blood levels of Perindosyl-Am 4/5Mg Tablet, which may make Perindosyl-Am 4/5Mg Tablet less effective.

How to manage the interaction:
Although taking Perindosyl-Am 4/5Mg Tablet and Fosphenytoin together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Perindosyl-Am 4/5Mg Tablet.

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, use only one serving for women and two servings for men.
  • Quit smoking to lower the risk of heart diseases.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
  • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
  • Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Perindosyl-Am 4/5Mg Tablet Substitute

Substitutes safety advice

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Perindosyl-Am 4/5Mg Tablet is recommended to use in dose and duration as advised by the doctor. Do not stop taking Perindosyl-Am 4/5Mg Tablet on your own as it may lead to a sudden rise in blood pressure increases the risk of heart attack and stroke.

Perindosyl-Am 4/5Mg Tablet can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.

Perindosyl-Am 4/5Mg Tablet may increase blood potassium levels in people with diabetes, poor kidney function, and patients using potassium-sparing diuretics or taking potassium supplements. Please consult your doctor before taking Perindosyl-Am 4/5Mg Tablet if you have diabetes.

Even though your blood pressure becomes normal after using Perindosyl-Am 4/5Mg Tablet , it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.

Avoid drinking alcohol because it can cause side effects. Avoid driving or hazardous activity until you know how this Perindosyl-Am 4/5Mg Tablet will affect you. Your reactions could be reduced. Avoid using salt substitutes or potassium supplements while taking Perindosyl-Am 4/5Mg Tablet , unless your doctor has told you.

Drug-Drug Interactions Checker List

  • LITHIUM
  • ESTRAMUSTINE
  • SPIRONOLACTONE
  • TRIAMTERENE
  • CYCLOSPORINE

Special Advise

  • Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
  • Perindosyl-Am 4/5Mg Tablet may affect patients with hepatic impairment, and hence it is used cautiously, and Liver function monitoring and Liver Function Tests are advised to monitor the liver enzyme changes.
  • Your doctor may advise you to get a regular kidney function test, blood examinations for potassium levels and other electrolytes while using Perindosyl-Am 4/5Mg Tablet to rule out any renal impairment.
  • Do not take this medicine within 36 hours before or after taking medicine that contains sacubitril (antihypertensive drug).

Disease/Condition Glossary

Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower, and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke), and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg, and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nosebleed, vomiting, and chest pain.

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