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Reviewed By Hari Kumar , MBBS
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Composition :

PALBOCICLIB-75MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Piciclib 75 Capsule

Piciclib 75 Capsule belongs to the group of anti-cancer drugs used to treat certain types of breast cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body. Breast cancer is cancer that forms in the cells of the breast. It can form in the lobules, ducts or tubules of the breast or in the breast tissue itself.

Piciclib 75 Capsule contains Palbociclib that works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, Piciclib 75 Capsule is effective in controlling cancer cells from multiplying and is used in the treatment of breast cancer. 

Take Piciclib 75 Capsule as prescribed. In some cases, Piciclib 75 Capsule may cause certain common side effects such as weakness, loss of appetite, infections and dry skin. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist or worsen. 

It is advisable to inform the doctor if you are allergic to any of its components. Do not take Piciclib 75 Capsule if you are pregnant or breastfeeding. Piciclib 75 Capsule may cause tiredness, so drive only if you are alert. Piciclib 75 Capsule is not recommended for use in children below 18years. Keep your doctor informed about your health condition and medications to rule out any interactions.

Uses of Piciclib 75 Capsule

Breast Cancer

Directions for Use

Take Piciclib 75 Capsule preferably with a meal. Swallow it as a whole with water. Do not crush, chew or break it.

Medicinal Benefits

Piciclib 75 Capsule is an anti-cancer drug used in the treatment of a particular type of breast cancer that is hormone receptor-positive and human epidermal growth factor receptor-2-negative. Piciclib 75 Capsule works by blocking the production of proteins called cyclin-dependent kinase 4 and 6 that are responsible for cell growth and division. By blocking them, Piciclib 75 Capsule nips cell growth in the bud and prevents cancer cells from spreading further. Thus, Piciclib 75 Capsule helps treat breast cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Piciclib 75 Capsule

  • Loss of appetite
  • Dry skin
  • Weakness
  • Infection
  • Hair loss
  • Fever
  • Inflammation of the mouth and lips

Drug Warnings

Do not take St. John's wort or grapefruit/grapefruit juice with Piciclib 75 Capsule. It is advisable to inform the doctor if you are allergic to any of its components. Do not take Piciclib 75 Capsule if you are pregnant or breastfeeding. Piciclib 75 Capsule may cause tiredness, so drive only if you are alert. Piciclib 75 Capsule is not recommended for use in children below 18years. If you experience any signs or symptoms of infections, inform your doctor. Keep your doctor informed about your health condition and medications to rule out any interactions. Consult your doctor immediately if you experience symptoms such as dry cough, chest pain, difficulty breathing or shortness of breath as it could be an indication of lung inflammation

Drug-Drug Interactions

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PalbociclibCladribine
Severe
PalbociclibPosaconazole
Severe

Drug-Drug Interactions

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PalbociclibCladribine
Severe
How does the drug interact with Piciclib 75 Capsule 3 x:
Taking Cladribine with Piciclib 75 Capsule 3 x can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Piciclib 75 Capsule 3 x together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PalbociclibPosaconazole
Severe
How does the drug interact with Piciclib 75 Capsule 3 x:
When Piciclib 75 Capsule 3 x is taken with Posaconazole can increase the blood levels of Piciclib 75 Capsule 3 x.

How to manage the interaction:
Although there is an interaction between posaconazole and Piciclib 75 Capsule 3 x, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, diarrhea, less desire to eat, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PalbociclibKetoconazole
Severe
How does the drug interact with Piciclib 75 Capsule 3 x:
Coadministration of Ketoconazole and Piciclib 75 Capsule 3 x may increase the blood level of Piciclib 75 Capsule 3 x.

How to manage the interaction:
Although taking Ketoconazole and Piciclib 75 Capsule 3 x together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, diarrhea, loss of appetite, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet, more severely, consult a doctor. Without consulting a doctor, never stop taking any drugs.
PalbociclibMorphine
Severe
How does the drug interact with Piciclib 75 Capsule 3 x:
Co-administration of Piciclib 75 Capsule 3 x with Morphine may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Morphine with Piciclib 75 Capsule 3 x can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water as dehydration is often seen in cancers.
  • Taking a stroll in the garden, or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Piciclib 75 Capsule Substitute

Substitutes safety advice
  • Paleno 75 mg Capsule 21's

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    234.25per tablet
  • Brespal 75 Capsule 21's

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    238.10per tablet
  • Ciclib 75 mg Capsule 21's

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    235.71per tablet
  • Palbace 75 mg Capsule 21's

    by AYUR

    942.86per tablet
  • Palbo 75 mg Capsule 21's

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    234.29per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Piciclib 75 Capsule works blocking proteins responsible for cell growth and division, thereby arresting the progression of cancer cells.

Do not stop taking Piciclib 75 Capsule on your own. You are advised to take Piciclib 75 Capsule for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Piciclib 75 Capsule.

A fibroadenoma is a benign state. Piciclib 75 Capsule is indicated only in case of cancers. Please consult your doctor in case of any concerns.

Piciclib 75 Capsule can reduce fertility in men. Therefore, consider sperm preservation before starting Piciclib 75 Capsule if you wish to father a child in the future. Effects on female fertility have not been established. Please consult your doctor before using Piciclib 75 Capsule.

Piciclib 75 Capsule may reduce white blood cell count, thereby weakening the immune system. This might increase your risk of infections. If you notice any signs or symptoms of infections, consult your doctor.

Drug-Drug Interactions Checker List

  • RITONAVIR
  • NELFINAVIR
  • SAQUINAVIR
  • LOPINAVIR
  • TELAPREVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • VORICONAZOLE
  • POSACONAZOLE
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • ABATACEPT
  • QUINIDINE
  • COLCHICINE
  • ALFENTANIL
  • FENTANYL
  • TACROLIMUS
  • CYCLOSPORINE
  • PIMOZIDE
  • ERGOTAMINE

Special Advise

  • Discuss contraception with your doctor while taking Piciclib 75 Capsule.
  • People on treatment with Piciclib 75 Capsule should use additional contraception (barrier method such as condoms). Contraception should be continued 3 weeks post-treatment for women and 14 weeks post-treatment for men.
  • You may want to consider sperm storage before starting Piciclib 75 Capsule. Seek counsel on the same from a qualified healthcare individual and/or sperm bank. 
  • Regular complete blood count monitoring is advised.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer that develops in breast cells. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), in the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and can travel to lymph nodes which are a primary pathway for the cancer cells to move to other parts of the body. Symptoms of breast cancer include a lump in the breast or tissue thickening which feels different than the normal surrounding tissues, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin, and a lump or swelling under the arm. 

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