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About Pioglit MF 15 Tablet
Pioglit MF 15 Tablet is a combination drug consisting of Pioglitazone (Thiazolidinediones), and Metformin (Biguanides) which are called anti-diabetic drugs & used to lower blood sugar levels in diabetic patients. Type 2 diabetes mellitus used to be known as 'non-insulin-dependent diabetes mellitus (NIDDM)' or 'maturity-onset diabetes'. Type 2 diabetes develops if the body does not produce enough insulin, or where the insulin that your body makes does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.
Pioglit MF 15 Tablet is a blood sugar-lowering drug which contains a combination of Pioglitazone belonging to the class of thiazolidinediones & Metformin belonging to the class of biguanides. Pioglitazone decreases blood sugar and reverses the effects of Type II diabetes by activating switches (PPAR) inside cells to take up free glucose from blood and decrease its levels in blood. Metformin on the other hand decreases blood sugar by decreasing its formation and increasing its consumption by cells thereby decreasing high blood sugar levels. Pioglit MF 15 Tablet is used in adults to treat type 2 (non-insulin dependent) diabetes mellitus when treatment with metformin alone is not sufficient.
Pioglit MF 15 Tablet should be taken with food to avoid an upset stomach. Pioglit MF 15 Tablet should be taken at the same time of the day each time for best results. For better advice, your doctor will decide, what dose should be taken and it can change timely depending upon your condition. Some people may stomach ache, feeling sick (Nausea), vomiting, diarrhoea, loss of appetite, localized swelling (oedema), weight gain, headache, respiratory infection, numbness, taste disturbance etc . Most of these side effects of Pioglit MF 15 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Pioglit MF 15 Tablet should not be stopped even if you feel better, without consulting your doctor as sugar level keeps changing. If you stop taking Pioglit MF 15 Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Pioglit MF 15 Tablet should not be taken if you have type 1 diabetes mellitus, severe kidney or liver disease. Please inform your doctor if you have any heart disease, is or planning to get pregnant or breastfeeding.
Uses of Pioglit MF 15 Tablet
Directions for Use
Medicinal Benefits
Pioglit MF 15 Tablet lowers blood sugar in type II diabetic patients (Non insulin dependent ) & prevents diseases of the heart, kidneys, eyes & blood vessels in feet, which happens due to persistently high levels of blood sugar in diabetic patients. Pioglit MF 15 Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing. Pioglit MF 15 Tablet lowers blood sugar due to activation of cell switches (PPAR) to take up free glucose from blood & use it for energy production (Pioglitazones) & decrease production of glucose inside liver (Metformin) .
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Side Effects of Pioglit MF 15 Tablet
Drug Warnings
Pioglit MF 15 Tablet should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Pioglit MF 15 Tablet , might develop a rare but serious condition called lactic acidosis. In this condition, there is too much lactic acid accumulated in the blood that can damage the working of your liver and kidney required for the elimination of excess lactic acid from the blood. Before you start taking Pioglit MF 15 Tablet , tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 level. Pioglit MF 15 Tablet , when used with insulin, may extremely lower the blood sugar level leading to hypoglycemia condition, which can be fatal. In this case, your doctor may adjust the dose by lowering the dose of insulin or Pioglit MF 15 Tablet . Prolonged intake of Pioglit MF 15 Tablet may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. The use of Pioglit MF 15 Tablet should be stopped for a short time before having an X-ray procedure.
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Pioglit MF 15 Tablet can cause fluid retention which cause heart failure.The doctor usually recommends to start from a lower dose and increase the dose, slowly while treating patients who are at risk of heart failure. Heart failure is reported mainly in patients taking insulin & Pioglit MF 15 Tablet simultaneously.
There has been rare cases of liver damage in patients taking Pioglit MF 15 Tablet . The doctor usually screens the patient continuously during the course of treatment with Pioglit MF 15 Tablet . A patient is advised to visit doctor strictly as per what doctor has advised.
Pioglit MF 15 Tablet is contradictory to be used in patients with high blood pressure. Doctors consultation is required before taking this drug in a patient with high blood pressure.
Pioglit MF 15 Tablet is safe to be taken before driving a vehicle or operating machinery as far as blood sugar levels are stable. A patient is advised to take proper precautions and make sure that Pioglit MF 15 Tablet is not taken with another blood sugar lowering agent.
Not recommended to be taken with contraceptives. Pioglit MF 15 Tablet decreases the activity of oral contraceptives like Ethinyl estradiol by almost 30% and leads to failure of contraception.
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Special Advise
Contact your doctor immediately if you have nausea, vomiting, kussmaul breathing (laboured and deep), and generalised weakness which are symptoms of Lactic acidosis, a very rare but serious metabolic complication.
Disease/Condition Glossary
Type 2 diabetes is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or utilized by our body. This can cause high blood sugar levels (hyperglycaemia). Symptoms of type 2 diabetes include increased thirst, frequent urination, slow , increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), and retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and increase the chance of heart attack or stroke.
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