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  3. Piperum-D 500 Injection

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Piperum-D 500 Injection, Pack of 1 Injection
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

DORIPENEM-500MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Piperum-D 500 Injection

Piperum-D 500 Injection belongs to the group of antibiotic medicines called carbapenems. It is indicated in treating bacterial infections such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis). Bacterial infections are illnesses or conditions caused by bacterial growth or toxins (poisons).

Piperum-D 500 Injection contains doripenem. Doripenem is an antibacterial drug. It works by inhibiting bacterial enzymes called penicillin-binding proteins (PBPs) and shows a bactericidal effect. Thus, Piperum-D 500 Injection treats bacterial infections.

Piperum-D 500 Injection will be administered by a healthcare professional; do not self-administer. Sometimes, Piperum-D 500 Injection may cause injection site reactions, headaches, nausea, diarrhoea, rash, and phlebitis (vein inflammation). Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, consult your doctor.

Inform your doctor if you are allergic to any component in Piperum-D 500 Injection. If you are pregnant or breastfeeding, inform your doctor before taking Piperum-D 500 Injection. It is not recommended for use in children below 18 as safety and effectiveness have not been established. Keep your doctor up to date on your medical condition and medications to rule out any potential adverse effects or interactions.

Uses of Piperum-D 500 Injection

Bacterial infections (Complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis).

Directions for Use

A healthcare professional will administer Piperum-D 500 Injection. Do not self-administer.

Medicinal Benefits

Piperum-D 500 Injection contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, Piperum-D 500 Injection helps treat bacterial infections. It is indicated in treating bacterial infections such as complicated intra-abdominal infections and complicated urinary tract infections (including pyelonephritis).

Storage

Keep Piperum-D 500 Injection out of reach and sight of children.
Side effects of Piperum-D 500 Injection
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Managing Medication-Triggered Thrombophlebitis (Inflammation of a vein): A Step-by-Step Guide:
  • If you have symptoms such as pain, swelling, redness, or warmth in your veins after taking medication, contact your doctor right once. Share information about your symptoms, medication regimen, and medical history.
  • Your doctor will then assess your medication regimen to determine if it's contributing to the thrombophlebitis. This assessment will help identify the best course of action to manage your condition and prevent further complications.
  • Your doctor may suggest certain diet and lifestyle changes to help manage your condition. This may include increasing your intake of foods rich in omega-3 fatty acids, staying hydrated, exercising regularly, and maintaining a healthy weight. Your doctor may also advise medications to reduce inflammation, prevent blood clots, or manage pain if necessary.
  • If your condition does not improve or persists, consult your doctor and report your condition. Your doctor will assess your progress, adjust your treatment plan if necessary, and provide appropriate advice to ensure the best possible outcome.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.

Drug Warnings

Piperum-D 500 Injection is contraindicated in patients with known serious hypersensitivity to doripenem, other drugs in the same class, or patients who have demonstrated anaphylactic reactions to beta-lactams. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Piperum-D 500 Injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. If symptoms worsen or persist or new symptoms appear, patients should stop using the medicine and consult a doctor. Valproic acid lowers serum valproic acid concentrations. Patients with seizure disorders treated with valproic acid or sodium valproate are at a higher risk of having a seizure.

verifiedApollotooltip
DoripenemSodium Valproate
Severe
DoripenemDivalproex
Severe

Drug-Drug Interactions

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DoripenemSodium Valproate
Severe
How does the drug interact with Piperum-D 500 Injection:
Co-administration of sodium valproate with Piperum-D 500 Injection can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and sodium valproate can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DoripenemDivalproex
Severe
How does the drug interact with Piperum-D 500 Injection:
Co-administration of Divalproex and Piperum-D 500 Injection can reduce the blood levels of divalproex sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Divalproex with Piperum-D 500 Injection can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • It would be best to take probiotics after taking the full course of Piperum-D 500 Injection to restore some healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can help restore the intestine's good bacteria.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread and brown rice, should be included in your diet.
  • Avoid taking too many calcium-enriched foods and drinks as it might affect the working of Piperum-D 500 Injection.
  • Avoid intake of alcoholic beverages with Piperum-D 500 Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Piperum-D 500 Injection in fighting off infections.

Side Effects of Piperum-D 500 Injection

  • Redness, pain, or swelling at the injection site
  • Headaches
  • Nausea
  • Diarrhoea
  • Rash
  • Phlebitis (vein inflammation)

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

Piperum-D 500 Injection Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Piperum-D 500 Injection contains doripenem. Doripenem is an antibacterial drug. It works by killing bacteria. Thus, Piperum-D 500 Injection helps treat bacterial infections.

Caution should be exercised. Patients with seizure disorders who are being treated with valproic acid or sodium valproate are at a higher risk of having a seizure. It has been demonstrated that administering Piperum-D 500 Injection together with valproic acid lowers its (valproic acid) serum levels.

In some cases, Piperum-D 500 Injection may lead to Clostridium difficile-associated diarrhoea (ranging from mild to fatal colitis): in major cases, it gradually resolves over time. In case this condition persists, consult your doctor immediately.

Inform your doctor if you do not feel better even after finishing the full course of treatment. If the symptoms worsen while using this medicine, consult your doctor.

To reduce the development of antibiotic resistance and maintain the effectiveness of Piperum-D 500 Injection, it should only be used to treat or prevent infections that are proven or highly suspected to be caused by bacteria.

Usually, Piperum-D 500 Injection starts working soon after taking it. However, it may take a few days to kill all the harmful bacteria and make you feel better.

Drug-Drug Interactions Checker List

  • BCG VACCINE
  • CHOLERA VACCINE LIVE
  • TYPHOID VACCINE LIVE
  • VALPROIC ACID
  • DIVALPROEX SODIUM

Disease/Condition Glossary

Bacterial infections: A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect the body. Infectious or harmful bacteria can make you sick and reproduce quickly in the body. These harmful bacteria produce toxins, damaging tissue and making you sick. It can target any body part and multiply very quickly. When infected with bacteria, you can experience generalized symptoms like fever, chills, and fatigue. Anyone can become infected with a bacterial infection. But, people with weak immune systems or taking immunosuppressive medicine are more prone to bacterial infection.

Pyelonephritis: Pyelonephritis is caused by an ascending urinary tract infection that travels from the bladder to the kidneys. Fever, flank discomfort, nausea, vomiting, burning with urine, increased frequency, and urgency are common symptoms.

Have a query?

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Alcohol

Caution

Consuming alcohol with Piperum-D 500 Injection is not advisable as it may cause unpleasant side effects.

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Pregnancy

Consult your doctor

Please visit your doctor. There are no adequate and well-controlled studies in pregnant women. Your doctor will only provide a prescription if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor; there has been no significant research on the use of Piperum-D 500 Injection in breastfeeding women.

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Driving

Caution

It is unclear whether Piperum-D 500 Injection affects driving abilities, so don't drive or operate machinery if you're having trouble concentrating or reacting.

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Liver

Caution

Limited information was available about using Piperum-D 500 Injection in patients with liver disease. Inform your doctor before receiving Piperum-D 500 Injection if you have a history of liver diseases/conditions. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Piperum-D 500 Injection if you have had a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Safe if prescribed

It is not recommended for use in children below 18 years.

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