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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
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Manufacturer/Marketer :

Cadila Pharmaceuticals Ltd

Consume Type :

ORAL

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Not Returnable

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About Polycap Capsule

Polycap Capsule is a combination medicine used for the prevention of cardiovascular events and stroke. Polycap Capsule helps in lowering of blood pressure, heart rate, lipid levels and decreases the stickiness of platelets. Heart attack or stroke occurs due to the blockage of blood flow to the heart muscle. The blockade usually occurs due to build-up of fat/cholesterol in the coronary artery. Polycap Capsule lowers the risk of heart attack or stroke by controlling the blood pressure, lowering the fat and increasing HDL (good cholesterol) levels.
 
Polycap Capsule contains Simvastatin (lipid-lowering agent), Ramipril (ACE inhibitor), Atenolol (beta-blocker), Aspirin (anti-platelet) and Hydrochlorothiazide (diuretic). Simvastatin helps in lowering the levels of LDL (bad) cholesterol, triglycerides and raises the levels of HDL (good) cholesterol. Ramipril relaxes the blood vessels and allows smooth blood flow. Atenolol slows down the heart rate and makes it more efficient at pumping blood. Hydrochlorothiazide helps in removal of unneeded water and salts from the body. Aspirin decreases the formation of harmful clots by preventing the platelets from sticking together. Together, Polycap Capsule helps in lowering the risk of a heart attack. 
 
You are advised to take Polycap Capsule for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as weakness, indigestion, constipation, dizziness and musculoskeletal pain. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Do not take Polycap Capsule if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Talk to a doctor immediately if you become pregnant while taking Polycap Capsule . Consult your doctor before taking Polycap Capsule if you are breastfeeding. Polycap Capsule may cause dizziness, so be cautious while driving. Avoid consuming alcohol with Polycap Capsule as it could lead to increased dizziness. Polycap Capsule is not recommended for children as safety and effectiveness have not been established. Inform your doctor regarding your health condition and the medicines you are taking to rule out any side-effects/interactions.

Uses of Polycap Capsule

Prevention of heart attack or stroke

Directions for Use

Swallow Polycap Capsule a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Polycap Capsule is a combination of five drugs, namely: Simvastatin, Ramipril, Atenolol, Aspirin, and Hydrochlorothiazide. Polycap Capsule is used for the prevention of cardiovascular events and stroke. Polycap Capsule helps in lowering of blood pressure, heart rate, lipid levels, and decreases the stickiness of platelets. Simvastatin is a lipid-lowering agent that helps in lowering the levels of LDL (bad) cholesterol, triglycerides and raises the levels of HDL (good) cholesterol. Ramipril, Atenolol and Hydrochlorothiazide help in controlling blood pressure. Ramipril is an ACE inhibitor which relaxes the blood vessels and allows smooth blood flow. Atenolol is a beta-blocker that slows down the heart rate and makes it more efficient at pumping blood. Hydrochlorothiazide is a diuretic that helps remove unneeded water and salts from the body. Aspirin is an anti-platelet agent that decreases the formation of harmful clots by preventing the platelets from sticking together. Together, Polycap Capsule helps in lowering the risk of a heart attack. Polycap Capsule lowers the risk of heart attack or stroke by controlling blood pressure, lowering fat and increasing HDL levels.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Polycap Capsule if you are allergic to any of its contents, if you are taking fusidic acid or sacubitril. Inform your doctor if you are due to have surgery, drink large amounts of alcohol, if you have asthma, diabetes, overactive thyroid, pheochromocytoma (tumour of the adrenal gland), gout, glaucoma, stomach or intestinal bleeding or bleeding disorders, stomach ulcers, liver or kidney problems. Do not take Polycap Capsule if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Talk to a doctor immediately if you become pregnant while taking Polycap Capsule . Consult your doctor before taking Polycap Capsule if you are breastfeeding. Polycap Capsule may cause dizziness, so be cautious while driving. Avoid consuming alcohol with Polycap Capsule as it could lead to increased dizziness. Polycap Capsule is not recommended for children as safety and effectiveness have not been established.

Drug-Drug Interactions

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Critical

Drug-Drug Interactions

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How does the drug interact with Polycap Capsule:
Taking aliskiren together with Polycap Capsule may increase the risk of serious side effects such as kidney problems, low blood pressure, and high potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney problems, muscle paralysis and irregular heart rhythm.

How to manage the interaction:
Taking Polycap Capsule with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, consult your doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. It is advised to reduce the intake of foods high in potassium, including tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes. Do not discontinue any medications without a doctor's advice.
Critical
How does the drug interact with Polycap Capsule:
Taking Dofetilide and Polycap Capsule can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Dofetilide and Polycap Capsule together is not recommended as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Polycap Capsule:
Taking Cisapride and Polycap Capsule can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Combining Cisapride and Polycap Capsule together is generally avoided as it can possibly result in an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, or fast or pounding heartbeats, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Polycap Capsule:
Combining Ciclosporin and Polycap Capsule can increase the blood levels and effects of Polycap Capsule. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Ciclosporin and Polycap Capsule together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinTipranavir
Critical
How does the drug interact with Polycap Capsule:
Combining Tipranavir and Polycap Capsule can increase the blood levels and effects of Polycap Capsule. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Tipranavir and Polycap Capsule together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SimvastatinNelfinavir
Critical
How does the drug interact with Polycap Capsule:
Combining Nelfinavir and Polycap Capsule can increase the blood levels and effects of Polycap Capsule. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nelfinavir and Polycap Capsule together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Polycap Capsule:
Combining Darunavir and Polycap Capsule can increase the blood levels and effects of Polycap Capsule. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Darunavir and Polycap Capsule together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinTelaprevir
Critical
How does the drug interact with Polycap Capsule:
Combining Telaprevir and Polycap Capsule can increase the blood levels and effects of Polycap Capsule. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Telaprevir and Polycap Capsule together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinNefazodone
Critical
How does the drug interact with Polycap Capsule:
Combining Nefazodone and Polycap Capsule can increase the blood levels and effects of Polycap Capsule. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nefazodone and Polycap Capsule together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Polycap Capsule:
Taking Ritonavir and Polycap Capsule may increase the risk of side effects.

How to manage the interaction:
Taking Polycap Capsule with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, contact a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.
  • Consume low-salt and a low-fat diet.
  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
  • Limit salt and sugar intake.
  • Avoid smoking and alcohol consumption. 
  • Choose healthy fats and cut down on trans-fat.
  • Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.
  • Get active by doing any physical activity such as swimming, brisk walking or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Polycap Capsule is a combination of five drugs, namely: Simvastatin, Ramipril, Atenolol, Aspirin, and Hydrochlorothiazide. Simvastatin helps in lowering the levels of LDL (bad) cholesterol, triglycerides and raises the levels of HDL (good) cholesterol. Ramipril, Atenolol, and Hydrochlorothiazide help in controlling the blood pressure. Ramipril relaxes the blood vessels and allows smooth blood flow. Atenolol slows down the heart rate and makes it more efficient at pumping blood. Hydrochlorothiazide helps in removal of unneeded water and salts from the body. Aspirin decreases the formation of harmful clots by preventing the platelets from sticking together. Together, Polycap Capsule helps in lowering the risk of a heart attack.

Do not discontinue Polycap Capsule without consulting your doctor as it could increase the risk of a heart attack. To treat your condition effectually, continue taking Polycap Capsule for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Polycap Capsule .

Constipation could be a side-effect of Polycap Capsule . Drink plenty of fluids and eat fibre rich food if you experience constipation. Consult your doctor if you have severe constipation.

Polycap Capsule contains aspirin, hence it should not be taken by patients with haemorrhagic stroke as it causes bleeding, which could be dangerous. Haemorrhagic stroke is a condition in which there is bleeding in the brain due to a rupture of the blood vessel.

Orthostatic hypotension could be a side-effect of Polycap Capsule . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better. People taking Polycap Capsule are advised to monitor their blood pressure levels regularly to avoid such unpleasant events.

Polycap Capsule contains Simvastatin which helps in lowering the levels of LDL (bad) cholesterol, triglycerides and raises the levels of HDL (good) cholesterol.

Polycap Capsule should be administered with caution in patients with increased thyroid hormone levels. Abrupt withdrawal of this medicine may lead to a life-threatening condition called thyroid storm. Your doctor may adjust the dose or suggest an alternative medication.

Drug-Drug Interactions Checker List

  • FUSIDIC ACID
  • ERYTHROMYCIN
  • ESOMEPRAZOLE
  • LEVOTHYROXINE
  • PREGABALIN
  • FUROSEMIDE
  • SITAGLIPTIN
  • INSULIN GLARGINE
  • AMLODIPINE
  • METOPROLOL
  • ALPRAZOLAM
  • DULOXETINE
  • CLOPIDOGREL
  • CALCIUM
  • CHOLECALCIFEROL
  • VITAMIN D

Special Advise

  • Regular blood tests are advised to determine the effect of Polycap Capsule on lipids. 
  • Consult your doctor immediately if you experience muscle pain, weakness, or tenderness, especially if associated with fever or tiredness.
  • Polycap Capsule might affect test results for liver function and muscle enzyme (creatin-kinase). Inform the person doing the tests that you are taking Polycap Capsule .
  • It is advisable to have complete cholesterol tests (lipid profile test) at least once a year. It will help you to closely monitor your heart health and risk of heart attack and stroke. 
  • Regularly monitor blood pressure levels, heart rate and electrolyte levels.

Disease/Condition Glossary

Heart attack: Heart attack or stroke occurs due to the blockage of blood flow to the heart muscle. The blockade usually occurs due to the build-up of fat/cholesterol in the coronary artery. High cholesterol levels might lead to a build-up of fat on the walls of the arteries leading to blockage of blood flow to the heart and other body parts, which could cause heart disease, heart attack or stroke. Cholesterol is mainly of two types, namely bad cholesterol and good cholesterol. Bad cholesterol comprises low-density lipoprotein (LDL) and triglycerides (TG) which deposit fat in the arteries leading to their blockage. Good cholesterol consists of high-density lipoprotein (HDL), which prevents the deposition of fats. Symptoms of angina include pain or tightness in the chest, discomfort, pain in the neck, arms or back, weakness, lightheadedness and abnormal heartbeat. Risk factors include obesity, stress, smoking, high-fat diet, lack of exercise and genetics.

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