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Written By Veda Maddala , M Pharmacy
Reviewed By Sureshvarma D , MPharma
Non returnable*
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Polyxx-E 3 Injection

Polyxx-E 3 Injection belongs to a class of drugs called antibiotics used in the treatment of severe bacterial infections. Bacterial infection is a condition in which harmful bacteria grow in the body and cause infection. It can infect any part of the body and multiply very quickly. Polyxx-E 3 Injection does not work against infections caused by a virus.

Polyxx-E 3 Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damaging bacterial cell membranes and kills bacteria.

Take Polyxx-E 3 Injection as prescribed by your doctor. You are advised to take Polyxx-E 3 Injection for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience dizziness, stomach upset, tingling, or difficulty in breathing. Most of these side effects of Polyxx-E 3 Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Polyxx-E 3 Injection or any other medicines, please tell your doctor. If you have myasthenia gravis (muscle weakness), kidney problems, or porphyria (a disorder in the formation of red blood pigment), inform your doctor before taking Polyxx-E 3 Injection. If you are pregnant or breastfeeding, please inform your doctor before taking Polyxx-E 3 Injection. Special care should be taken in new-born and premature babies as kidneys are not developed fully. Drive only if you are alert as Polyxx-E 3 Injection may cause confusion, vision problems, or dizziness.  If you are on dialysis, inform your doctor before taking Polyxx-E 3 Injection so that the dose may be reduced accordingly.

Uses of Polyxx-E 3 Injection

Several bacterial infections

Directions for Use

Polyxx-E 3 Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Polyxx-E 3 Injection contains Colistimethate, a narrow-spectrum antibiotic that is active against gram-negative bacteria. Polyxx-E 3 Injection binds to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damages bacterial cell membranes and kills bacteria. Polyxx-E 3 Injection is used when other antibiotics are not suitable.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Polyxx-E 3 Injection

  • Dizziness
  • Stomach upset
  • Tingling
  • Difficulty in breathing

Drug Warnings

If you are allergic to Polyxx-E 3 Injection or any other medicines, please tell your doctor. If you have myasthenia gravis (muscle weakness), kidney problems, or porphyria (a disorder in the formation of red blood pigment), inform your doctor before taking Polyxx-E 3 Injection. If you are pregnant or breastfeeding, please inform your doctor before taking Polyxx-E 3 Injection. Special care should be taken in new-born and premature babies as kidneys are not developed fully. Drive only if you are alert as Polyxx-E 3 Injection may cause confusion, vision problems, or dizziness. If you are on dialysis, inform your doctor before taking Polyxx-E 3 Injection so that the dose may be reduced accordingly. Inform your anesthetist that you are taking Polyxx-E 3 Injection as it may increase the effects of muscle relaxants used in general anesthesia. You are recommended to complete the full course of Polyxx-E 3 Injection as prescribed by your doctor for effective results.

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
ColistinAtracurium
Severe

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
How does the drug interact with Polyxx-E 3 Injection:
Coadministration of Polyxx-E 3 Injection along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Polyxx-E 3 Injection with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.
ColistinAtracurium
Severe
How does the drug interact with Polyxx-E 3 Injection:
Coadministration of Atracurium with Polyxx-E 3 Injection can increase the risk of Atracurium side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and Atracurium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinPipecuronium bromide
Severe
How does the drug interact with Polyxx-E 3 Injection:
Coadministration of Pipecuronium bromide with Polyxx-E 3 Injection may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and pipecuronium bromide, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinIohexol
Severe
How does the drug interact with Polyxx-E 3 Injection:
Combining Polyxx-E 3 Injection with Iohexol can increase the effect or side effects of Iohexol.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and Iohexol, you can take these medicines if prescribed by your doctor. However, if you experience vomiting, loss of appetite, irregular urination, swelling, shortness of breath, muscle cramps, or weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinStreptomycin
Severe
How does the drug interact with Polyxx-E 3 Injection:
Coadministration of Streptomycin with Polyxx-E 3 Injection may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and Streptomycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, muscle pain, dizziness, or palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ColistinEverolimus
Severe
How does the drug interact with Polyxx-E 3 Injection:
Coadministration of Polyxx-E 3 Injection with Everolimus can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and Everolimus, it can be taken if prescribed by a doctor. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, or weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
ColistinAmikacin
Severe
How does the drug interact with Polyxx-E 3 Injection:
Coadministration of Polyxx-E 3 Injection with Amikacin can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and Amikacin, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ColistinNeomycin
Severe
How does the drug interact with Polyxx-E 3 Injection:
Combining Polyxx-E 3 Injection with Neomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and Neomycin, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinAdefovir dipivoxil
Severe
How does the drug interact with Polyxx-E 3 Injection:
Combining Polyxx-E 3 Injection with Adefovir dipivoxil may decrease Polyxx-E 3 Injection's excretion rate, which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and Adefovir dipivoxil, you can take these medicines together if prescribed by your doctor. However, if you experience any irregular urination, swelling, shortness of breath, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinVecuronium
Severe
How does the drug interact with Polyxx-E 3 Injection:
Using Vecuronium with Polyxx-E 3 Injection can make Vecuronium more effective in therapy.

How to manage the interaction:
Although there is a possible interaction between Polyxx-E 3 Injection and Vecuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take probiotics after completing the full course of Polyxx-E 3 Injection to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like cheese, yogurt, kombucha, sauerkraut, and kimchi can restore the good bacteria of the intestine.
  • Include fiber-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains such as whole-grain bread and brown rice should be included in your diet.
  • Make sure you drink plenty of water or other fluids every day while you are taking Polyxx-E 3 Injection.
  • Avoid alcohol consumption as it may increase adverse effects.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Polyxx-E 3 Injection Substitute

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Author Details

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Polyxx-E 3 Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stops the leakage of cell contents. Thereby, damages bacterial cell membranes and kills bacteria.

You are not recommended to take Polyxx-E 3 Injection with gentamicin as co-administration of these two medicines may increase the risk of severe adverse effects such as kidney problems, hearing loss or respiratory depression especially in elderly people and in those who have preexisting kidney disease or who are dehydrated. However, please consult your doctor before taking Polyxx-E 3 Injection with other medicines.

Polyxx-E 3 Injection may cause dizziness as a common side effect. Avoid driving if you feel dizzy after taking Polyxx-E 3 Injection. However, if the condition persists or worsens, please consult a doctor.

Polyxx-E 3 Injection should be used with caution in patients receiving dialysis (the process of filtration and purification of blood using a machine). Therefore, if you are receiving dialysis, please inform your doctor before taking Polyxx-E 3 Injection so that the dose may be adjusted accordingly.

You are recommended to take Polyxx-E 3 Injection with extreme caution if you have kidney disease as it may worsen the condition. Regular monitoring of kidney functioning is recommended while taking Polyxx-E 3 Injection. Therefore, inform your doctor if you have any kidney problems before taking Polyxx-E 3 Injection.

Drug-Drug Interactions Checker List

  • AMIKACIN
  • NETILIMICIN
  • TOBRAMYCIN
  • GENTAMICIN
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • AZITHROMYCIN
  • CIPROFLOXACIN
  • NORFLOXACIN
  • OFLOXACIN

Special Advise

  • Regular blood tests are recommended to monitor the levels of Polyxx-E 3 Injection in blood and kidney functioning.
  • Inform your anaesthetist that you are taking Polyxx-E 3 Injection as it may increase the effects of muscle relaxants used in general anaesthesia.

Disease/Condition Glossary

Bacterial infection: It is a condition in which harmful bacteria grows in the body and cause infection. It can target any part of the body and multiple very quickly. Bacteria come in three basic shapes, namely spherical, rod or spiral-shaped. Bacteria may be gram-positive (have thick cell wall) or gram-negative (do not have cell wall). Appropriate tests are done to identify bacterial strains, and based on the results, proper medication is prescribed. Some common symptoms of bacterial infection include cough, fever and tiredness.

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