Prealdonil Tablet 10's belongs to a group of medications called 'anti-convulsants' primarily used in the prevention of neuropathic pain.  It is also widely used to treat diabetic neuropathy (nerve damage due to diabetes). Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling, or burning sensation.

Prealdonil Tablet 10's is a combination of two drugs: Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by changing the way in which nerves send messages to your brain. Epalrestat is an aldose reductase inhibitor.  It blocks the accumulation of sorbitol in the nerve, which causes diabetic nerve disease by inhibiting aldose reductase. It relieves the symptoms of neuropathic pain include numbness and pain in the hands, feet, leg cramps, etc. Together, Prealdonil Tablet 10's helps to treat neuropathic pain (pain due to nerve damage) especially treat nerve damage due to diabetes mellitus.

You are advised to take Prealdonil Tablet 10's for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects such as weight gain, somnolence (sleepiness/drowsiness), dry mouth, blurred vision, weight gain, urine discoloration, and thinking abnormal (primarily difficulty with concentration/attention). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Prealdonil Tablet 10's without consulting your doctor as it could cause withdrawal symptoms. Do not take Prealdonil Tablet 10's if you are pregnant or breastfeeding unless prescribed by the doctor. Prealdonil Tablet 10's should not be given to children as safety and effectiveness have not been established. Prealdonil Tablet 10's causes drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Prealdonil Tablet 10's as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Prealdonil Tablet 10's is a combination of two drugs, namely; Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by calming the damaged or overactive nerves in your body that may cause pain, thereby decreasing the number of pain signals sent out by damaged nerves in the body. Overall it reduces the pain from damaged or irritated nerves due to chronic conditions like, diabetes, trauma or epilepsy. Epalrestat works by inhibiting the aldose reductase enzyme which catalyzes the conversion of glucose to sorbitol and reduces the accumulation of sorbitol in the nerve. In diabetes (hyperglycemia) the accumulation of sorbitol in the nerve occurs and causes various diabetic complications like diabetic peripheral neuropathy, diabetic retinopathy (damage to the blood vessels of the eye due to diabetes), and diabetic nephropathy (diabetic kidney disease). Together, Prealdonil Tablet 10's helps to treat neuropathic pain (pain due to nerve damage) and diabetic neuropathy (nerve damage) which is a common chronic complication in patients with diabetes.

• Nausea
• Vomiting
• Diarrhea
• Dizziness
• Somnolence (sleepiness/drowsiness)
• Blurred vision
• Uncoordinated body movements
• Increased liver enzymes
• Urine discoloration

Do not take Prealdonil Tablet 10's if you are known to be allergic to Prealdonil Tablet 10's. Inform your doctor before taking Prealdonil Tablet 10's if you have or had heart problems, bipolar syndrome, severe liver disease or porphyria and kidney impairments. Please do not stop taking Prealdonil Tablet 10's without consulting your doctor as it could cause withdrawal symptoms. Do not take Prealdonil Tablet 10's if you are pregnant or breastfeeding unless prescribed by the doctor. Prealdonil Tablet 10's should not be given to children as safety and effectiveness have not been established. Taking Prealdonil Tablet 10's with opioids analgesics or painkillers can cause respiratory failure, coma and even leading to death, so avoid its intake together. If you have taken MAO inhibitors in the last 14 days, please do not take Prealdonil Tablet 10's as intake of Prealdonil Tablet 10's and MAO inhibitor together can cause life-threatening drug interaction. Prealdonil Tablet 10's causes drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Prealdonil Tablet 10's as it could lead to increased drowsiness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies such as killing or harming yourself.  Keep your doctor informed about your health condition and medicines to rule out any side effects. 

Drug-Drug Interaction: Prealdonil Tablet 10's may interact with a painkiller (morphine, fentanyl, oxycodone, tramadol, codeine) and medicines used for treating anxiety (lorazepam, diazepam, clonazepam).

Drug-Food Interaction: Prealdonil Tablet 10's may interact with alcohol. Therefore, avoid consuming alcohol while taking Prealdonil Tablet 10's as it may increase side effects such as drowsiness, dizziness or difficulty in concentrating. 

Drug-Disease Interaction: If you have suicidal ideation or behavior, drug addiction, chronic pulmonary insufficiency, heart problems, liver/kidney impairment, inform your doctor before taking Prealdonil Tablet 10's.

• MORPHINE
• FENTANYL
• OXYCODONE
• TRAMADOL
• CODEINE
• LORAZEPAM
• CLONAZEPAM
• DIAZEPAM

• Include food rich in vitamins B and D in your diet.
• Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
• Exercising regularly helps in improving overall health and combating pain.
• Rest well, and get plenty of sleep.
• Try taking a warm bath as it can be soothing.
• Avoid smoking and alcohol consumption.
• Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.
• Acupuncture can be helpful by stimulating pressure points.
• Using essential oils for massages can help increase circulation.

• People taking Prealdonil Tablet 10's should be closely monitored for suicidal thoughts or behaviour. Speak with your doctor immediately if you experience suicidal tendencies such as killing or harming yourself.
• Using of Prealdonil Tablet 10's may cause sleepiness or drowsiness, try to prevent driving, operating heavy machinery, and any work that requires concentration and attention.
• Your doctor may advise you to maintain a healthy diet as Prealdonil Tablet 10's may cause weight gain.
• To prevent nerve damage due to diabetes mellitus, wear proper footwear and examine your feet every day to detect lesions early. 
• Epalrestat in Prealdonil Tablet 10's cause yellow-brown or red urine discolorations. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Prealdonil Tablet 10's.
• Regular monitoring of blood sugar levels is recommended.

Neuropathic pain: Neuropathic pain is caused due to damage to sensory nerves. It is caused by chronic progressive nerve disease, or due to infection or injury. The pain could be intermittent or continuous, which is felt as prickling, stabbing, tingling, or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury, the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning, or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful). Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. Symptoms include numbness and pain in the legs and feet.