Prealdonil Tablet 10's

Written By Urvashi Bharti , MBBS

Reviewed By Sunny S , MBBS

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MRP ₹584.5

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₹87.7 Cashback (15%)

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Prescription drug

Whats That

About Prealdonil Tablet

Prealdonil Tablet belongs to a group of medications called 'anti-convulsants' primarily used in the prevention of neuropathic pain. It is also widely used to treat diabetic neuropathy (nerve damage due to diabetes). Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling, or burning sensation.

Prealdonil Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by changing the way in which nerves send messages to your brain. Epalrestat is an aldose reductase inhibitor. It blocks the accumulation of sorbitol in the nerve, which causes diabetic nerve disease by inhibiting aldose reductase. It relieves the symptoms of neuropathic pain include numbness and pain in the hands, feet, leg cramps, etc. Together, Prealdonil Tablet helps to treat neuropathic pain (pain due to nerve damage) especially treat nerve damage due to diabetes mellitus.

You are advised to take Prealdonil Tablet for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects such as weight gain, somnolence (sleepiness/drowsiness), dry mouth, blurred vision, weight gain, urine discoloration, and thinking abnormal (primarily difficulty with concentration/attention). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Prealdonil Tablet without consulting your doctor as it could cause withdrawal symptoms. Do not take Prealdonil Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Prealdonil Tablet should not be given to children as safety and effectiveness have not been established. Prealdonil Tablet causes drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Prealdonil Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Prealdonil Tablet

Neuropathic pain, Diabetic Neuropathy

Directions for Use

Take Prealdonil Tablet with or without food as advised by the doctor. Swallow it as a whole with a glass of water, do not chew or break it.

Medicinal Benefits

Prealdonil Tablet is a combination of two drugs, namely; Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by calming the damaged or overactive nerves in your body that may cause pain, thereby decreasing the number of pain signals sent out by damaged nerves in the body. Overall it reduces the pain from damaged or irritated nerves due to chronic conditions like, diabetes, trauma or epilepsy. Epalrestat works by inhibiting the aldose reductase enzyme which catalyzes the conversion of glucose to sorbitol and reduces the accumulation of sorbitol in the nerve. In diabetes (hyperglycemia) the accumulation of sorbitol in the nerve occurs and causes various diabetic complications like diabetic peripheral neuropathy, diabetic retinopathy (damage to the blood vessels of the eye due to diabetes), and diabetic nephropathy (diabetic kidney disease). Together, Prealdonil Tablet helps to treat neuropathic pain (pain due to nerve damage) and diabetic neuropathy (nerve damage) which is a common chronic complication in patients with diabetes.

Storage

Keep Prealdonil Tablet out of the sight and reach of children.

Side effects of Prealdonil Tablet

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drowsiness

Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Swelling In The Feet And Ankles

Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
Gently massage the swollen area with firm but not painful pressure.
Keep the swollen area clean and moisturized to prevent injury and infection.
Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Irregular Heart Beat

Eat potassium-rich foods like avocados, bananas, spinach, and potatoes.
Stay hydrated by drinking plenty of water.
Exercise regularly and maintain healthy weight.
Manage stress.
Prioritize 7-9 hours of sleep each night to help your body and mind recharge.
Avoid smoking and limit intake of caffeine.
Practice stress-reducing activities like meditation, yoga, or deep breathing to help calm your mind and body.
Avoid stimulants and illegal drugs.
Call your doctor if it worsens.

Drug Warnings

Do not take Prealdonil Tablet if you are known to be allergic to Prealdonil Tablet . Inform your doctor before taking Prealdonil Tablet if you have or had heart problems, bipolar syndrome, severe liver disease or porphyria and kidney impairments. Please do not stop taking Prealdonil Tablet without consulting your doctor as it could cause withdrawal symptoms. Do not take Prealdonil Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Prealdonil Tablet should not be given to children as safety and effectiveness have not been established. Taking Prealdonil Tablet with opioids analgesics or painkillers can cause respiratory failure, coma and even leading to death, so avoid its intake together. If you have taken MAO inhibitors in the last 14 days, please do not take Prealdonil Tablet as intake of Prealdonil Tablet and MAO inhibitor together can cause life-threatening drug interaction. Prealdonil Tablet causes drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Prealdonil Tablet as it could lead to increased drowsiness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies such as killing or harming yourself. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

PregabalinSodium oxybate

Severe

PregabalinKetamine

Severe

Drug-Drug Interactions

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PregabalinSodium oxybate

Severe

How does the drug interact with Prealdonil Tablet:
Using Sodium oxybate together with Prealdonil Tablet may increase the risk of side effects.

How to manage the interaction:
Although taking Prealdonil Tablet with Sodium oxybate together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult the doctor. For at least six hours after taking sodium oxybate, avoid operating machinery or engaging in potentially dangerous activities. Also, be careful when getting up from a sitting or lying down posture. Do not stop using any medications without talking to a doctor.

PregabalinKetamine

Severe

How does the drug interact with Prealdonil Tablet:
Taking Ketamine with Prealdonil Tablet may increase the risk of side effects.

How to manage the interaction:
Although taking Prealdonil Tablet and ketamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as dizziness, drowsiness, confusion, difficulty concentrating, breathing difficulty, consult the doctor. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

PregabalinHydrocodone

Severe

How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Hydrocodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydrocodone and Prealdonil Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

PregabalinCodeine

Severe

How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Codeine may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Codeine and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

PregabalinEsketamine

Severe

How does the drug interact with Prealdonil Tablet:
When Prealdonil Tablet and Esketamine are taken together, it may increase the risk of side effects.

How to manage the interaction:
Although taking Prealdonil Tablet and Esketamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

PregabalinTapentadol

Severe

How does the drug interact with Prealdonil Tablet:
Using Tapentadol together with Prealdonil Tablet may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Prealdonil Tablet with Tapentadol can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not exceed the doses or frequency and duration of use advised by the doctor. Do not discontinue any medications without consulting a doctor.

PregabalinFentanyl

Severe

How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Fentanyl can increase the risk of side effects.

How to manage the interaction:
Although taking fentanyl together with Prealdonil Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you have dizziness, sleepiness, difficulty concentrating, or impairment in judgment. Do not stop taking any medication without consulting a doctor.

PregabalinHydromorphone

Severe

How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Hydromorphone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydromorphone and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

PregabalinAlfentanil

Severe

How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Alfentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Prealdonil Tablet and Alfentanil together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in- judgment, reaction speed and motor coordination, consult the doctor immediately. Avoid driving or operating dangerous machinery. Do not exceed the doses, frequency, or duration of usage advised by the doctor. Do not discontinue any medications without consulting a doctor.

PregabalinDezocine

Severe

How does the drug interact with Prealdonil Tablet:
Using Prealdonil Tablet together with Dezocine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Dezocine and Prealdonil Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Include food rich in vitamins B and D in your diet.
Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
Exercising regularly helps in improving overall health and combating pain.
Rest well, and get plenty of sleep.
Try taking a warm bath as it can be soothing.
Avoid smoking and alcohol consumption.
Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.
Acupuncture can be helpful by stimulating pressure points.
Using essential oils for massages can help increase circulation.

Side Effects of Prealdonil Tablet

Nausea
Vomiting
Diarrhea
Dizziness
Somnolence (sleepiness/drowsiness)
Blurred vision
Uncoordinated body movements
Increased liver enzymes
Urine discoloration

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Author Details

Written By

Urvashi Bharti

MBBS

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:36 AM IST

We provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Prealdonil Tablet work?

Prealdonil Tablet contains Pregabalin and Epalrestat. Prealdonil Tablet is a combination of two drugs: Pregabalin (anti-convulsant) and Epalrestat (carboxylic acid derivative). Pregabalin works by changing the way in which nerves send messages to your brain. Epalrestat is an aldose reductase inhibitor. It blocks the accumulation of sorbitol in the nerve, which causes diabetic nerve disease by inhibiting aldose reductase. It relieves the symptoms of neuropathic pain include numbness and pain of the hands, feet, leg cramps, etc. Together, Prealdonil Tablet helps to treat neuropathic pain (pain due to nerve damage) especially treat nerve damage due to diabetes mellitus.

How to cope with dry mouth?

Dry mouth could be a side-effect of Prealdonil Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Can I take Prealdonil Tablet with painkillers like tramadol?

No, you are not recommended to take Prealdonil Tablet with tramadol as co-administration of these medicines may cause breathing problems, drowsiness and even lead to a stage of coma. So, before using Prealdonil Tablet with pain killers like oxycodone or any other opioids analgesics, you are advised to contact your doctor so that the dosage may be adjusted accordingly to use safely.

Does Prealdonil Tablet cause suicidal thoughts?

People taking Prealdonil Tablet should be closely monitored for suicidal thoughts or behavior. Do not be reluctant to speak with your doctor immediately if you experience suicidal tendencies.

Is Prealdonil Tablet used to treat diabetic neuropathy?

Prealdonil Tablet is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in legs and feet.

Can I stop taking Prealdonil Tablet if I feel well?

Do not discontinue Prealdonil Tablet without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually continue taking Prealdonil Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Prealdonil Tablet , your doctor will reduce the dose gradually.

Can Prealdonil Tablet cause weight gain?

Yes, Prealdonil Tablet may cause weight gain because as it increases your hunger. However, regular physical exercise and a balanced diet with low-calorie food may help you keep your weight stable. Please consult the doctor if you have any further concerns to keep your weight stable.

Drug-Drug Interactions Checker List

MORPHINE
FENTANYL
OXYCODONE
TRAMADOL
CODEINE
LORAZEPAM
CLONAZEPAM
DIAZEPAM

Special Advise

People taking Prealdonil Tablet should be closely monitored for suicidal thoughts or behaviour. Speak with your doctor immediately if you experience suicidal tendencies such as killing or harming yourself.
Using of Prealdonil Tablet may cause sleepiness or drowsiness, try to prevent driving, operating heavy machinery, and any work that requires concentration and attention.
Your doctor may advise you to maintain a healthy diet as Prealdonil Tablet may cause weight gain.
To prevent nerve damage due to diabetes mellitus, wear proper footwear and examine your feet every day to detect lesions early.
Epalrestat in Prealdonil Tablet cause yellow-brown or red urine discolorations. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Prealdonil Tablet .
Regular monitoring of blood sugar levels is recommended.

Disease/Condition Glossary

Neuropathic pain: Neuropathic pain is caused due to damage to sensory nerves. It is caused by chronic progressive nerve disease, or due to infection or injury. The pain could be intermittent or continuous, which is felt as prickling, stabbing, tingling, or burning sensation. A feeling of numbness and loss of sensations is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury, the body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning, or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events usually not painful). Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. Symptoms include numbness and pain in the legs and feet.