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Not for online sale
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

rxMedicinePrescription drug

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Manufacturer/Marketer :

Solis Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pregasol Trio Tablet

Pregasol Trio Tablet is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).

Pregasol Trio Tablet combines three drugs: Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin is a vitamin that aids in producing myelin, which protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Pregasol Trio Tablet helps to treat neuropathic pain.

Take Pregasol Trio Tablet as prescribed. Your doctor will decide the dose and duration based on your medical condition. In some cases, Pregasol Trio Tablet may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. These side effects do not necessitate medical attention and will subside gradually over time. However, you should consult your doctor if you are experiencing these side effects regularly.

Please do not take Pregasol Trio Tablet if you are allergic to any of its ingredients. Consult your doctor before taking Pregasol Trio Tablet if you are pregnant or breastfeeding. Pregasol Trio Tablet may cause drowsiness and dizziness, so drive only if alert. Pregasol Trio Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Pregasol Trio Tablet as it could increase dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to avoid side effects.

Uses of Pregasol Trio Tablet

Neuropathic pain

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Pregasol Trio Tablet is a combination of three drugs: Mecobalamin, Pregabalin, and Nortriptyline. Pregasol Trio Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Mecobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Together, Pregasol Trio Tablet helps to treat neuropathic pain.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to any of the ingredients in Pregasol Trio Tablet , do not consume it. Please do not stop taking Pregasol Trio Tablet without consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Pregasol Trio Tablet unless your doctor has prescribed it. Pregasol Trio Tablet may cause drowsiness and dizziness; therefore, drive only if alert. Pregasol Trio Tablet is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Pregasol Trio Tablet as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Pregasol Trio Tablet:
Coadministration of Pregasol Trio Tablet with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregasol Trio Tablet with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Pregasol Trio Tablet:
Co-administration of Pregasol Trio Tablet with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Pregasol Trio Tablet with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregasol Trio Tablet:
Coadministration of Pregasol Trio Tablet with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregasol Trio Tablet with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Pregasol Trio Tablet:
Coadministration of Pregasol Trio Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Pregasol Trio Tablet with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregasol Trio Tablet:
Coadministration of Pregasol Trio Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Pregasol Trio Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Pregasol Trio Tablet:
Using Pregasol Trio Tablet together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Pregasol Trio Tablet is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
NortriptylinePotassium citrate
Critical
How does the drug interact with Pregasol Trio Tablet:
Coadministration of Pregasol Trio Tablet with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Pregasol Trio Tablet with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineMethadone
Severe
How does the drug interact with Pregasol Trio Tablet:
Coadministration of Pregasol Trio Tablet with Methadone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Pregasol Trio Tablet with Methadone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregasol Trio Tablet:
Coadministration of Pregasol Trio Tablet with Tramadol may cause seizures (sudden, violent, uncontrollable contraction of a group of muscles).

How to manage the interaction:
Taking Pregasol Trio Tablet with tramadol together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregasol Trio Tablet:
Coadministration of Pregasol Trio Tablet with Clozapine can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Pregasol Trio Tablet with Clozapine together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include vitamin B and D-rich foods in your diet.
  • Your diet should include Cayenne pepper because it can help with neuropathic pain.
  • Exercising regularly helps to improve overall health and combat pain.
  • Rest well and get plenty of rest.
  • Taking a warm bath can be very relaxing.
  • Avoid smoking and drinking alcohol.
  • Meditation and yoga can reduce stress, and pain sensitivity, and improve coping skills.
  • Acupuncture, by stimulating pressure points, can be beneficial.
  • Massages with essential oils can help increase circulation.

Habit Forming

No

Therapeutic Class

NEUTRACEUTICAL

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Pregasol Trio Tablet contains Mecobalamin, Pregabalin, and Nortriptyline. Mecobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Together, Pregasol Trio Tablet helps to treat neuropathic pain.

Pregasol Trio Tablet contains pregabalin. It may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.

Dry mouth could be a side-effect of Pregasol Trio Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Do not stop taking Pregasol Trio Tablet without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Pregasol Trio Tablet for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Pregasol Trio Tablet , do not be afraid to speak with your doctor.

Pregasol Trio Tablet is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.

Pregasol Trio Tablet may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.

Drug-Drug Interactions Checker List

  • DULOXETINE
  • SERTRALINE
  • ESCITALOPRAM
  • CODEINE
  • HYDROCODONE
  • MORPHINE
  • OXYCODONE
  • TRAMADOL
  • ACETAMINOPHEN
  • TOPIRAMATE
  • ALPRAZOLAM
  • ZOLPIDEM
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • CYCLOBENZAPRINE
  • ONDANSETRON
  • ST JOHN'S WORT

Special Advise

Pregasol Trio Tablet contains Nortriptyline (antidepressant), which can lead to suicidal thoughts. Suicidal thoughts or behaviour should be closely monitored in people taking Pregasol Trio Tablet . If you have suicidal thoughts, don't hesitate to talk to your doctor immediately.

Disease/Condition Glossary

Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also familiar with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury. The body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping and evoked pain (pain caused by events usually not painful).

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