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Written By Divya L , PharmaD
Reviewed By Santoshini Reddy G , M Pharmacy
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About Pregator Capsule

Pregator Capsule is a combination medication indicated for the management of neuropathic pain. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms of neuropathic pain include shooting, burning pain followed by tingling and numbness (loss of sensation). Neuropathic pain can be caused due to amputation of limbs, diabetic neuropathy (nerve damage due to excess blood sugar level), excessive alcohol intake (alcoholism) and cancer treatment via chemotherapy.

Pregator Capsule contains Pregabalin (anticonvulsant), Methylcobalamin (vitamin B12), Alpha-lipoic acid (antioxidant), Pyridoxine hydrochloride (vitamin B6), and Folic acid (vitamin B9). Pregabalin affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain and lowering the risk of seizures (fits). Methylcobalamin and Pyridoxine hydrochloride help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and the brain. Folic acid helps in delivering essential nutrients to the nerves. Together, Pregator Capsule provides relief from neuropathic pain.

Use Pregator Capsule as prescribed by your doctor. In some cases, you may experience certain common side effects, such as dizziness, sleepiness, tiredness, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Pregator Capsule without consulting your doctor, as it could cause withdrawal symptoms. Consult your doctor before starting Pregator Capsule if you are pregnant or breastfeeding. Pregator Capsule may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Pregator Capsule as it could lead to increased dizziness and sleepiness. Pregator Capsule should not be given to children as safety and effectiveness have not been established.

Uses of Pregator Capsule

Neuropathic pain.

Directions for Use

Swallow it as a whole with a glass of water; do not chew, crush or break it.

Medicinal Benefits

Pregator Capsule is a combination of five drugs: Pregabalin (anti-convulsant or antiepileptic), methylcobalamin (vitamin B12), alpha-lipoic acid (antioxidant), pyridoxine hydrochloride (vitamin B6), and folic acid (vitamin B9). Pregator Capsule is used to treat neuropathic pain. Pregabalin affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain and lowering the risk of seizures. Methylcobalamin and Pyridoxine hydrochloride help in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Alpha-lipoic acid helps in providing a protective effect on the nerve tissues and brain. Folic acid helps in providing essential nutrients to the nerves. Together, Pregator Capsule helps in providing relief from neuropathic pain.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Pregator Capsule if you are allergic to any of its contents. Inform your doctor before taking Pregator Capsule if you have/had heart problems or bipolar syndrome. Please do not stop taking Pregator Capsule without consulting your doctor as it could cause withdrawal symptoms. Do not take Pregator Capsule if you are pregnant or breastfeeding unless prescribed by the doctor. Pregator Capsule causes drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol along with Pregator Capsule as it could lead to increased dizziness and sleepiness. Pregator Capsule should not be given to children as safety and effectiveness have not been established. Consult your doctor immediately if you experience suicidal tendencies.

Drug-Drug Interactions

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PregabalinEsketamine
Severe

Drug-Drug Interactions

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How does the drug interact with Pregator Capsule:
Using Pregator Capsule together with Butorphanol causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Butorphanol and Pregator Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinEsketamine
Severe
How does the drug interact with Pregator Capsule:
When Pregator Capsule and Esketamine are taken together, it may increase the risk of side effects.

How to manage the interaction:
Although taking Pregator Capsule and Esketamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregator Capsule:
Taking Ketamine with Pregator Capsule may increase the risk of side effects.

How to manage the interaction:
Although taking Pregator Capsule and ketamine together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience symptoms such as dizziness, drowsiness, confusion, difficulty concentrating, breathing difficulty, consult the doctor. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregator Capsule:
When Tramadol is used with Pregator Capsule, it may possibly lead to side effects such as respiratory difficulties, unconsciousness.

How to manage the interaction:
Although taking tramadol and Pregator Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinRemifentanil
Severe
How does the drug interact with Pregator Capsule:
Using Pregator Capsule together with Remifentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking remifentanil and Pregator Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinDezocine
Severe
How does the drug interact with Pregator Capsule:
Using Pregator Capsule together with Dezocine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Dezocine and Pregator Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregator Capsule:
Using Pregator Capsule together with Nalbuphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Nalbuphine and Pregator Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinPethidine
Severe
How does the drug interact with Pregator Capsule:
Using Pregator Capsule together with Pethidine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking pethidine and Pregator Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
PregabalinOxycodone
Severe
How does the drug interact with Pregator Capsule:
Using Pregator Capsule together with Oxycodone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking oxycodone and Pregator Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not exceed the doses, frequency, or duration of usage advised by a doctor. Avoid driving or operating dangerous machinery. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregator Capsule:
Using Pregator Capsule together with Buprenorphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Buprenorphine and Pregator Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in- judgment, reaction speed and motor coordination, consult the doctor immediately. Avoid driving or operating dangerous machinery. Do not exceed the doses, frequency, or duration of usage advised by the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain. 
  • Rest well, and get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Pregator Capsule contains Pregabalin, methylcobalamin, alpha-lipoic acid, pyridoxine hydrochloride, and folic acid. It affects the chemicals in the brain that send pain signals to the nervous system, thereby relieving nerve pain. Pregator Capsule also helps reduce further nerve damage in neuropathy. It works by improving blood circulation to peripheral body parts and thus relieving pain.

Do not discontinue Pregator Capsule without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually continue taking Pregator Capsule for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Pregator Capsule ; your doctor will reduce the dose gradually.

People taking Pregator Capsule should be closely monitored for suicidal thoughts or behaviour. Do not be reluctant to speak with your doctor immediately if you experience suicidal tendencies.

Pregator Capsule may decrease sperm count and may affect fertility in men. However, it is unclear whether these effects would occur. So it is advisable to ask your doctor about your risk.

Drug-Drug Interactions Checker List

  • AMITRIPTYLINE
  • DULOXETINE
  • CODEINE
  • MORPHINE
  • TRAMADOL
  • GABAPENTIN
  • PHENOBARBITAL
  • DIAZEPAM
  • METFORMIN
  • METHOTREXATE
  • SULFASALAZINE
  • CHLORAMPHENICOL
  • ALTRETAMINE
  • LEVODOPA

Disease/Condition Glossary

Neuropathic pain: It is a nervous disorder that occurs due to nerve damage caused by chronic progressive nerve disease, limb amputation, diabetes or due to infection or injury. The pain could be intermittent or continuous, felt as a prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensation is also common with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain that is not triggered by an injury, the body sends the pain signals unpromptedly. Symptoms include spontaneous, un-triggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).

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