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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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About Premarin 0.3 Tablet

Premarin 0.3 Tablet belongs to the class of hormones used as ‘hormone replacement therapy’ to treat symptoms and conditions associated with menopause. During menopause, estrogen levels decrease, leading to hot flushes (feeling of heat over the face, neck, and chest). Women with menopause are at risk of developing osteoporosis (thinning of bones). Premarin 0.3 Tablet can be used to prevent osteoporosis after menopause.

Premarin 0.3 Tablet contains ‘conjugated estrogens’, which is used as hormone replacement therapy (HRT). It works by replacing the estrogen hormone in menopausal women. It also regulates the secretions of hormones such as luteinizing hormone (LH) (necessary for sexual function and the menstrual cycle) and follicle-stimulating hormone (FSH) (regulates the menstrual cycle). These effects help to improve the symptoms of menopause.

Premarin 0.3 Tablet should be taken as advised by your doctor. The dose of medicine and duration of treatment will be decided by the doctor based on your medical condition. Premarin 0.3 Tablet may cause certain side effects such as abnormal vaginal bleeding or spotting, vaginal discharge, pain and swelling in the breasts, discharge from the nipples, changes in breast tissue, feeling or being sick, bloating, abdominal pain, headache, dizziness, mood changes, irritability, joint pain, leg cramps, increased or decreased libido (sexual desire), swelling of face or ankles, rashes on the skin, changes in hair growth, eye, weight and triglyceride levels (fats), intolerance to glucose, memory loss and jaundice (yellowing of the skin or eyes).

Premarin 0.3 Tablet should be avoided if you have a history of breast cancer, endometrial cancer (cancer of the lining of the womb), unexplained vaginal bleeding, untreated endometrial hyperplasia (thickening of the womb lining), have a blood clot in the veins (thrombosis), in the legs (deep vein thrombosis) or the lungs (pulmonary embolism), blood clotting disorder, heart attack or angina (chest pain), inherited porphyria (a blood disorder) or liver disease. It is not recommended for use in pregnant and breastfeeding women. Stop taking Premarin 0.3 Tablet and consult your doctor immediately if you are allergic to it or if you develop jaundice (yellowing of the skin and eyes), high blood pressure and migraine-like headache, become pregnant or notice signs of a blood clot such as redness, swelling and pain in the legs, sudden chest pain or difficulty in breathing. Inform your doctor if you have any intolerance to sugar.

Uses of Premarin 0.3 Tablet

Menopause

Directions for Use

Your doctor determines the dose of this medicine. Swallow it as a whole with a glass of water. Do not crush, chew or break it. Take this medication at a fixed time every day for better results.

Medicinal Benefits

Premarin 0.3 Tablet contains ‘conjugated estrogens’, which is used for hormone replacement therapy (HRT). In menopause, estrogen levels become too low, so Premarin 0.3 Tablet works by replacing this hormone.  It also regulates the secretions of other hormones from the pituitary gland, such as luteinizing hormone (LH) (necessary for sexual function and the menstrual cycle) and follicle-stimulating hormone (FSH) (regulates the menstrual cycle). These effects help to reduce the symptoms of menopause.

Storage

Keep Premarin 0.3 Tablet out of sight and reach of children.

Drug Warnings

Before starting treatment with Premarin 0.3 Tablet , inform your doctor if you are allergic to it. Also inform if you have fibroids inside the womb, growth of womb lining outside the womb (endometriosis), excessive thickening of the womb lining (endometrial hyperplasia), increased risk of developing blood clots, increased risk of getting estrogen-sensitive cancer (in people with a family history of breast cancer), high blood pressure, diseases associated with liver, kidney, or heart, fluid retention (oedema), diabetes, gallbladder stones, migraine or severe headache, systemic lupus erythematosus, epilepsy (fits), asthma, osteosclerosis (a condition affecting eardrum and hearing), hypocalcemia (low calcium levels in the blood), and high levels of fat in the blood. Premarin 0.3 Tablet increases the risk of endometrial hyperplasia and endometrial cancer, so your doctor may prescribe you the hormonal medicine ‘progesterone’ to minimize this risk. Inform your doctor if you are pregnant or breastfeeding, as Premarin 0.3 Tablet is not recommended for use in such a population. Long-term use of high dosages of this medication may raise your risk of heart attack, stroke, blood clots, dementia, breast cancer, or uterine cancer. Discuss this risk with your doctor. If you still have your uterus (womb), see your doctor about whether you should take progestin.

Drug-Drug Interactions

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Conjugated EstrogensPomalidomide
Severe
Conjugated EstrogensCarfilzomib
Severe

Drug-Drug Interactions

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Conjugated EstrogensPomalidomide
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Coadministration of Pomalidomide with Premarin 0.3 mg Tablet may increase the risk of developing blood clots.

How to manage the interaction:
Although taking Conjugated estrogen with Pomalidomide can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience chest discomfort, breathing difficulty, coughing up blood, swelling in an arm or leg, or weakness, consult a doctor. Do not stop using any medications without consulting a doctor.
Conjugated EstrogensCarfilzomib
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Combining Carfilzomib with Premarin 0.3 mg Tablet can increase the risk of developing blood clots.

How to manage the interaction:
Although taking Conjugated estrogen and Carfilzomib together can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience chest discomfort, shortness of breath, weakness, or blurred vision, consult a doctor. Do not stop using any medications without consulting a doctor.
Conjugated EstrogensLenalidomide
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Coadministration of Lenalidomide with Premarin 0.3 mg Tablet may increase the risk of developing unwanted blood clots.

How to manage the interaction:
Although there is an interaction between lenalidomide and Premarin 0.3 mg Tablet, it can be taken if prescribed by a doctor. However, if you experience chest pain, shortness of breath, coughing up blood, blurred vision, swelling in an arm or leg, and weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Conjugated EstrogensDantrolene
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Coadministration of Premarin 0.3 mg Tablet and dantrolene can increase the risk of developing liver problems.

How to manage the interaction:
Although Conjugated estrogen and Dantrolene together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, joint pain, weakness, unusual bleeding or bruising, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not stop using any medications without consulting a doctor.
Conjugated EstrogensThalidomide
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Coadministration of Thalidomide with Premarin 0.3 mg Tablet may increase the risk of developing blood clots.

How to manage the interaction:
Although taking Thalidomide and Premarin 0.3 mg Tablet can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience chest pain, shortness of breath, coughing up blood, swelling in an arm, or weakness. Do not discontinue any medications without consulting a doctor.
Conjugated EstrogensLetrozole
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Coadministration of Premarin 0.3 mg Tablet with Letrozole may reduce the effect of Letrozole.

How to manage the interaction:
Although taking Conjugated estrogen and Letrozole together can result in an interaction, it can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
Conjugated EstrogensTranexamic acid
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Co-administration of Conjugated estrogen with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Conjugated estrogen with Tranexamic acid may result in interaction, it can be taken only if your doctor has advised it. However, if you experience chest pain, shortness of breath, coughing up blood, or weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Conjugated EstrogensExemestane
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Coadministration of Premarin 0.3 mg Tablet with Exemestane may reduce the effect of Exemestane.

How to manage the interaction:
Although taking Conjugated estrogen and Exemestane together can result in an interaction, they can be taken together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
Conjugated EstrogensAnastrozole
Severe
How does the drug interact with Premarin 0.3 mg Tablet:
Coadministration of Premarin 0.3 mg Tablet with Anastrozole may reduce the effectiveness of Anastrozole.

How to manage the interaction:
Although taking Conjugated estrogen and Anastrozole together can result in an interaction, they can be taken if prescribed by a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Wear loose, layered clothing during the nighttime, especially in warm weather. This prevents hot flushes.
  • Manage your weight. Shed excess weight by exercising regularly if you are obese or overweight. 
  • Talk to a psychologist if you feel low, sad, isolated, or have any sleeping issues.
  • Apply moisturizers to prevent skin dryness.
  • Limit alcohol intake and quit smoking.
  • Try to eat foods that are rich in iron and Vitamin C, including red meat, shellfish, eggs, beans, and leafy green vegetables.

Side Effects of Premarin 0.3 Tablet

  • Nausea
  • Stomach pain
  • Headache
  • Back pain
  • Depression,
  • Sleep problems (insomnia)
  • Breast pain
  • Vaginal itching or discharge
  • Changes in your menstrual periods
  • Unusual vaginal bleeding
  • Changes in vision or speech

Habit Forming

No

Therapeutic Class

HORMONES

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Premarin 0.3 Tablet works by replacing the deficient estrogen hormone in menopausal women. It effectively reduces the symptoms and improves health conditions.

Premarin 0.3 Tablet is not a form of contraception. Because pregnancy is possible early in menopause while you are still experiencing monthly cycles, you should consult with your doctor about another (non-hormonal) type of birth control.

Your doctor decides the dose of Premarin 0.3 Tablet based on your health condition. It is advised not to take more than the recommended dose.

Premarin 0.3 Tablet may cause weight changes. Premarin 0.3 Tablet contains 'conjugated estrogen' that regulates metabolism and body weight. However, exercise regularly and eat a well-balanced diet to control body weight. In case of unusual weight gain, consult your doctor.

Premarin 0.3 Tablet increases the risk of breast cancer when it is used as Hormonal replacement therapy for longer durations.

Drug-Drug Interactions Checker List

  • PHENOBARBITAL
  • PHENYTOIN
  • CARBAMAZEPINE
  • RIFAMPICIN
  • RIFABUTIN
  • EFAVIRENZ
  • RITONAVIR
  • NELFINAVIR
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • KETOCONAZOLE
  • ITRACONAZOLE
  • CIMETIDINE
  • DEXAMETHASONE
  • NEVIRAPINE
  • HYPERICUM PERFORATUM
  • METYRAPONE

Special Advise

  • While giving blood for tests, inform your doctor that you are taking Premarin 0.3 Tablet as this medicine may affect some test results. 
  • Take calcium and vitamin D supplements to promote bone health and reduce the risk of osteoporosis.
  • Your doctor may advise you to get blood tests to examine the risks of taking this medication.

Disease/Condition Glossary

Menopause: Menopause occurs when a woman is between 45 and 55 and has not had a period for 12 months or more. However, some women may also experience menopause before 45 years or after 55 years. It occurs due to decreased production of estrogen hormone. The change in levels of other hormones such as progesterone, luteinizing hormone and the follicle-stimulating hormone is also observed during menopause. It causes symptoms such as hot flushes, vaginal dryness, insomnia (sleeplessness), weight gain, reduced sexual desire, sore breasts, hair loss, unwanted hair growth, headache and urinary tract infections.

Have a query?

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Alcohol

Caution

Consumption of alcohol while using this medicine may cause interactions. Discuss with your doctor for more information.

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Pregnancy

Unsafe

Premarin 0.3 Tablet is a category X drug. This medicine is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor. Your doctor may prescribe an alternative based on your medical condition.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and reduce the production of milk. Hence, inform your doctor before starting treatment with Premarin 0.3 Tablet if you are breastfeeding. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Not applicable

Premarin 0.3 Tablet may not affect your ability to drive.

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Liver

Unsafe

Premarin 0.3 Tablet should not be used in patients with liver diseases. Hence inform your doctor if you have/had a history of liver disease before starting treatment with this medicine.

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Kidney

Caution

Premarin 0.3 Tablet should be used with caution in patients with severe kidney diseases. Hence If you have a pre-existing or a history of kidney disease, inform your doctor before taking Premarin 0.3 Tablet . Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

The safety of Premarin 0.3 Tablet in children is not established. Hence, the use is not recommended.

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