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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

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Composition :

PRAMIPEXOLE-0.5MG

Manufacturer/Marketer :

Alteus Biogenics Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Prexol 0.5 mg Tablet

Prexol 0.5 mg Tablet belongs to a group of antiparkinson agents or dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Parkinson’s disease is a progressive neurological disorder in which the first signs are problems with movements. Willis-Ekbom disease is a condition which causes the uncontrollable urge to move the legs.

Prexol 0.5 mg Tablet contains 'Pramipexole' that works by mimicking the action of dopamine (acting in place of dopamine), a natural substance found in the brain needed to control body movement. This triggers the nerve impulses in the brain that control body movements.

In some cases, you may experience certain common side-effects such as sleepiness, nausea, constipation, dizziness, fatigue, hallucinations, dry mouth, muscle spasms, and peripheral oedema (leg swelling due to fluid overload). Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not discontinue Prexol 0.5 mg Tablet on your own. Consult your doctor if you are pregnant or breastfeeding. Prexol 0.5 mg Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Prexol 0.5 mg Tablet should not be used in children below 18 years. Avoid consuming alcohol along with Prexol 0.5 mg Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Prexol 0.5 mg Tablet may cause orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Uses of Prexol 0.5 mg Tablet

Parkinson’s disease, Willis Ekbom disease (restless legs syndrome)

Directions for Use

Swallow Prexol 0.5 mg Tablet as a whole with water; do not crush, break or chew it. For restless leg syndrome: Prexol 0.5 mg Tablet should be taken 2-3 hours before bedtime.

Medicinal Benefits

Prexol 0.5 mg Tablet belongs to a group of antiparkinson agents called dopamine agonists used to treat the symptoms of Parkinson’s disease and moderate to severe Willis-Ekbom disease (restless legs syndrome) in adults. Prexol 0.5 mg Tablet binds to the dopamine receptor and mimics its action. Dopamine is a naturally-occurring neurotransmitter in the brain. Dopamine is absent or reduced in people with Parkinson’s disease. Prexol 0.5 mg Tablet works by stimulating the dopamine receptors in the brain. This triggers the nerve impulses in the brain that control body movements. Prexol 0.5 mg Tablet helps in relieving the symptoms of Parkinson’s disease, such as muscle spasms, tremors, stiffness, and poor muscle control.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Prexol 0.5 mg Tablet

  • Nausea
  • Low blood pressure
  • Dizziness
  • Constipation
  • Fatigue
  • Headache
  • Dry mouth
  • Muscle spasms

Drug Warnings

Do not take Prexol 0.5 mg Tablet if you are allergic to any of its contents. Talk to your doctor before taking Prexol 0.5 mg Tablet if you have kidney problems, hallucinations, dyskinesia (abnormal limb movements), dystonia (inability to keep the neck straight), sleepiness or suddenly falling asleep, psychosis, vision impairment, severe heart or blood vessel disease, or augmentation (symptoms start earlier). Inform your doctor if you experience symptoms such as apathy, anxiety, depression, fatigue, sweating or pain after dose reduction or stopping Prexol 0.5 mg Tablet . Prexol 0.5 mg Tablet may cause intense urges such as increased sex drive, gambling, overeating and wasting money. Consult your doctor if you are pregnant or breastfeeding. Prexol 0.5 mg Tablet may cause drowsiness and dizziness, do not drive unless you are alert. Prexol 0.5 mg Tablet should not be given to children below 18 years. Avoid consuming alcohol along with Prexol 0.5 mg Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Prexol 0.5 mg Tablet causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). 

Drug-Drug Interactions

verifiedApollotooltip
PramipexoleOlanzapine
Critical
PramipexoleRisperidone
Critical

Drug-Drug Interactions

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PramipexoleOlanzapine
Critical
How does the drug interact with Prexol 0.5 mg Tablet:
Taking Olanzapine with Prexol 0.5 mg Tablet can increase the risk and severity of side effects and reduce the effectiveness of Prexol 0.5 mg Tablet.

How to manage the interaction:
Co-administration of Olanzapine and Prexol 0.5 mg Tablet is not recommended as it leads to an interaction, it can be taken if advised by a doctor. If you experience any symptoms such as drowsiness, dizziness, and lightheadedness, contact a doctor immediately. Avoid driving or operating dangerous machinery, and be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
PramipexoleRisperidone
Critical
How does the drug interact with Prexol 0.5 mg Tablet:
Taking Risperidone with Prexol 0.5 mg Tablet may reduce the effectiveness of Prexol 0.5 mg Tablet.

How to manage the interaction:
Taking Risperidone with Prexol 0.5 mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, and lightheadedness contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PramipexoleSodium oxybate
Severe
How does the drug interact with Prexol 0.5 mg Tablet:
Taking Sodium oxybate with Prexol 0.5 mg Tablet may increase he risk of side effects.

How to manage the interaction:
Taking Prexol 0.5 mg Tablet with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleSodium oxybate
Severe
How does the drug interact with Prexol 0.5 mg Tablet:
Taking Sodium oxybate with Prexol 0.5 mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Prexol 0.5 mg Tablet with Sodium oxybate together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult a doctor. Do not discontinue the medications without consulting a doctor.
PramipexoleEsketamine
Severe
How does the drug interact with Prexol 0.5 mg Tablet:
Taking Esketamine with Prexol 0.5 mg Tablet may increase the risk of side effects.

How to manage the interaction:
Although taking Prexol 0.5 mg Tablet and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue any medications without a doctor's advice.
PramipexoleEsketamine
Severe
How does the drug interact with Prexol 0.5 mg Tablet:
Combining Esketamine with Prexol 0.5 mg Tablet may increase side effects

How to manage the interaction:
Although taking Prexol 0.5 mg Tablet and Esketamine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, reaction speed, and motor coordination, consult a doctor. Do not discontinue the medication without consulting a doctor.
PramipexoleAmisulpride
Severe
How does the drug interact with Prexol 0.5 mg Tablet:
Taking Amisulpride with Prexol 0.5 mg Tablet may decrease the efficacy of both medications.

How to manage the interaction:
Although taking amisulpride along with Prexol 0.5 mg Tablet can result in an interaction, it can be taken if a doctor has advised it. Avoid jobs that demand mental awareness and exercise caution while rising from a sitting or sleeping posture. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include a diet rich in iron, folate and magnesium. 
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Prexol 0.5 mg Tablet works by acting like dopamine and triggering the nerve impulses in the brain that controls our body movements like restless leg syndrome and Parkinson's.

Do not discontinue Prexol 0.5 mg Tablet without consulting your doctor as it could lead to recurring symptoms. To treat your condition effectually, continue taking Prexol 0.5 mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Prexol 0.5 mg Tablet .

Prexol 0.5 mg Tablet may lower the blood pressure than normal leading to hypotension (low blood pressure), especially during the initial days of treatment. Do not stand up suddenly, rise slowly to avoid a sudden drop in blood pressure. Regularly monitor your blood pressure levels while taking Prexol 0.5 mg Tablet .

Dry mouth could be a side-effect of Prexol 0.5 mg Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Prexol 0.5 mg Tablet may cause peripheral oedema (swelling of lower legs and hands due to fluid overload). So, avoid sitting or standing for too long.

Hallucination is a medical condition in which the person may feel, hear or believe things that are not true, see things that are not there, feel unusually suspicious or confused. If you experience hallucinations, please talk to your doctor immediately.

Drug-Drug Interactions Checker List

  • AMITRIPTYLINE
  • DULOXETINE
  • TRAZODONE
  • FLUOXETINE
  • DIPHENHYDRAMINE
  • CETIRIZINE
  • GABAPENTIN
  • PREGABALIN
  • MEMANTINE
  • ACETAMINOPHEN
  • HYDROCODONE
  • TRAMADOL

Special Advise

Patients and their caretakers (midwife/nurse) should be alerted as Prexol 0.5 mg Tablet may cause intense urges such as increased sex drive, gambling, overeating and wasting money.

Disease/Condition Glossary

Parkinson’s disease: It is a progressive neurological disorder in which the first signs are problems with movements. Dopamine is a naturally-occurring neurotransmitter in the brain which is reduced or absent in people with Parkinson’s disease. Due to this problems arise with smooth and coordinated movements. Symptoms include decreased ability to smell, stooped posture, changes in voice, constipation, small/cramped handwriting, tremor, slow movements, stiffness of arms, legs, and trunk, and problems with balance. 

Willis-Ekbom disease (restless leg syndrome): It is a condition which causes the uncontrollable urge to move the legs. The urge to move their legs is more intense when a person is trying to sleep or relax. This interferes with sleep leading to daytime sleepiness and fatigue. Symptoms include an uncontrollable urge to move the legs, tingling, crawling or pulling sensations in the legs.

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