Profaze Tablet

Profaze Tablet belongs to the class of 'anti-migraine drugs' primarily used to treat migraine. Migraine is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Its symptoms include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

Profaze Tablet consists of 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. Propranolol works by reducing cerebral (brain) blood flow by directly acting on the brain's blood vessels. It also inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation. It effectively treats and reduces the severity and frequency of migraine headaches. Flunarizine belongs to the class of calcium channel blockers. It improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. It is also used to treat vertigo (spinning sensation).

Your doctor will decide the dose and duration based on the severity of your pain. Common side effects of Profaze Tablet include dry weight gain, slow heart rate, tiredness, depression, drowsiness, abnormal dreams, and cold extremities (hands and feet). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Profaze Tablet. Profaze Tablet may cause weight gain in some cases, so avoid eating junk and eat a healthy, balanced diet, including home-cooked food. Consult your doctor before taking Profaze Tablet if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol along with Profaze Tablet as it could lead to increased drowsiness.

Profaze Tablet is used to treat migraine. It consists of 'Propranolol' and 'Flunarizine'. Propranolol is a beta-blocker and has anxiolytic (anxiety-reducing), anti-arrhythmic, and antihypertensive properties. It works by lowering cerebral (brain) blood flow and inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation. It reduces the severity and frequency of migraine headaches. Flunarizine is a channel blocker that improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. 

• Weight gain
• Slow heart rate
• Tiredness
• Depression
• Drowsiness
• Abnormal dreams
• Cold extremities (hands and feet)

Inform your doctor if you have any history of liver or kidney diseases, breathing problems (asthma, bronchitis, emphysema), diabetes, heart failure, heart rhythm problems (sinus bradycardia, Wolff-Parkinson-White syndrome, atrioventricular block), overactive thyroid, blood circulation problems (Raynaud's disease), adrenal gland tumour (pheochromocytoma), depression, metabolic acidosis (excess acid in the blood), and myasthenia gravis (muscle weakness) before starting Profaze Tablet. Please consult your doctor if you are pregnant and planning to conceive if the doctor advised you Profaze Tablet. Avoid consuming alcohol along with Profaze Tablet as it could lead to increased dizziness and drowsiness.

Drug-Drug Interaction: Profaze Tablet may interact with mood disorder medicines (alprazolam, quetiapine, aripiprazole), drugs treating sleeping problems (zolpidem), respiratory drugs (diphenhydramine), antidepressants (sertraline, duloxetine, fluoxetine), and fits medicine (carbamazepine, phenytoin).

Drug-Food Interaction: Alcohol may cause dizziness and drowsiness when taken with Profaze Tablet.

Drug-Disease Interaction: Before using Profaze Tablet, let your doctor know if you have any liver, kidney or heart diseases, asthma, depression, muscle disorders, metabolic acidosis, diabetes, and alcohol dependency.

• ALPRAZOLAM
• QUETIAPINE
• ARIPIPRAZOLE
• ZOLPIDEM
• DIPHENHYDRAMINE
• SERTRALINE
• DULOXETINE
• FLUOXETINE
• CARBAMAZEPINE
• PHENYTOIN

• Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. Instead, eat a healthy diet and do regular exercise to avoid weight gain caused due to Profaze Tablet.
• Avoid loud music, extreme temperatures, bright lights, and noisy places as it can increase headache.
• You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
• Drink enough water to stay hydrated and limit or avoid alcohol and caffeine to relieve headaches.
• Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
• You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.
• Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

• Let your doctor know that you are taking Profaze Tablet if you are undergoing any medical tests.
• Beta-blockers like Propranolol can mask hypoglycaemia symptoms (low blood sugar) or hyperthyroidism (high thyroid levels).
• It is advised to inform your doctor if you have diabetes or thyroid disease before using Profaze Tablet.
• Beta-blockers can also cause changes in serum lipid profiles. Patients with pre-existing hyperlipidaemia (high lipid levels) should be closely monitored if using Profaze Tablet.

Migraine: It is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Symptoms of migraine may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound. Migraine can be triggered by various factors like foods (eggs, tomatoes, onions, dairy products, wheat, pasta, citrus fruits, nitrites found in foods, alcohol, and red wine), hormonal changes, sleep changes, stress, loud noises, and medications.