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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
Non returnable*
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Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Proluton Depot 250 mg Injection 1 ml

Proluton Depot 250 mg Injection 1 ml belongs to the category of a synthetic progesterone female hormone called progestin used to prevent premature labor. Premature labor can start before 37 completed weeks of pregnancy and can be caused due to premature rupture of membranes, high blood pressure during pregnancy (pre-eclampsia), and poor diet. Preterm labor symptoms include leaking fluid or bleeding from the vagina, feeling of pressure in the pelvis, and cramps that feel like menstrual cramps regularly.

Proluton Depot 250 mg Injection 1 ml contains 'Hydroxyprogesterone' a progestin (female hormones) that modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. Proluton Depot 250 mg Injection 1 ml prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labor. Proluton Depot 250 mg Injection 1 ml should be administered only to those pregnant women who are pregnant with one baby or who have had a preterm (premature) delivery of one baby in the past.

Proluton Depot 250 mg Injection 1 ml will be administered by a healthcare professional. Do not self-administer. In some cases, you may experience certain common side effects such as nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhea. Not everybody experiences these side effects. Most of the side effects of Proluton Depot 250 mg Injection 1 ml do not require medical attention and gradually resolve over time. Talk to your doctor if you feel any discomfort while taking Proluton Depot 250 mg Injection 1 ml.

Before starting Proluton Depot 250 mg Injection 1 ml, please inform your doctor if you have an allergy to any medicines, have unusual vaginal bleeding related to your pregnancy, liver disease, severe hypertension (high blood pressure), or history of breast cancer uterus, or vagina. Tell your doctor before using Proluton Depot 250 mg Injection 1 ml if you have had pre-eclampsia (high blood pressure during pregnancy), thromboembolic disorders (blood clot form in the blood), diabetes, depression, or epilepsy. Proluton Depot 250 mg Injection 1 ml may cause dizziness, so be cautious while driving and operating machinery. Avoid alcohol consumption to prevent unpleasant side effects. Inform your doctor about all medicines you are taking and about your health condition to rule out any unpleasant side effects.

Uses of Proluton Depot 250 mg Injection 1 ml

Premature labor

Directions for Use

Proluton Depot 250 mg Injection 1 ml will be administered by a healthcare professional. Do not self-administer Proluton Depot 250 mg Injection 1 ml.

Medicinal Benefits

Proluton Depot 250 mg Injection 1 ml contains “Hydroxyprogesterone” a progestin (female hormones) that is used in pregnant women who have delivered a baby too early (preterm) in the past. It works by modulating the immune response of pregnant women to prevent the rejection of the embryo and allow its attachment to the uterus. Proluton Depot 250 mg Injection 1 ml prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had a past premature delivery.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Proluton Depot 250 mg Injection 1 ml

  • Nausea
  • Vomiting
  • Itching
  • Hives (skin rashes)
  • Swelling in the face, lips, tongue, or throat
  • Diarrhea

Drug Warnings

You should not take Proluton Depot 250 mg Injection 1 ml without a doctor's advice. Before starting Proluton Depot 250 mg Injection 1 ml, please inform your doctor if you have an allergy to any medicines. Do not take Proluton Depot 250 mg Injection 1 ml if you have unusual vaginal bleeding that is not related to your pregnancy, liver disease, severe hypertension (high blood pressure), or history of cancer of the breast, uterus or vagina. Tell your doctor before using Proluton Depot 250 mg Injection 1 ml if you have had preeclampsia (high blood pressure during pregnancy), thromboembolic disorders (blood clot form in the blood), diabetes, depression, or epilepsy. Do not take Proluton Depot 250 mg Injection 1 ml on your own. Proluton Depot 250 mg Injection 1 ml can cause dizziness and drowsiness. Use caution while driving a motor vehicle as dizziness or drowsiness may occur. Let your doctor know if you are a breastfeeding mother. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Proluton Depot 250 mg Injection 1 ml is not recommended for children younger than 16 years old. Proluton Depot 250 mg Injection 1 ml is not intended for use in the first trimester of pregnancy. 

Drug-Drug Interactions

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HydroxyprogesteroneItraconazole
Severe
HydroxyprogesteroneNicotine
Severe

Drug-Drug Interactions

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HydroxyprogesteroneItraconazole
Severe
How does the drug interact with Proluton Depot 250 mg Injection 1 ml:
Coadministration of Itraconazole and Proluton Depot 250 mg Injection 1 ml can cause an increase in the levels of Proluton Depot 250 mg Injection 1 ml.

How to manage the interaction:
Using Itraconazole and Proluton Depot 250 mg Injection 1 ml together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or vaginal bleeding, consult the doctor . Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneNicotine
Severe
How does the drug interact with Proluton Depot 250 mg Injection 1 ml:
Coadministration of Nicotine and Proluton Depot 250 mg Injection 1 ml may reduce the blood levels and effects of nicotine.

How to manage the interaction:
Using Nicotine and Proluton Depot 250 mg Injection 1 ml together can lead to an interaction, they can be taken if advised by your doctor. Consult your doctor if your symptoms do not improve or worsen. Do not stop using any medications without a doctor's advice.
HydroxyprogesteroneRifabutin
Severe
How does the drug interact with Proluton Depot 250 mg Injection 1 ml:
Coadministration of Rifabutin and Proluton Depot 250 mg Injection 1 ml may reduce the blood levels and effects of Proluton Depot 250 mg Injection 1 ml.

How to manage the interaction:
Using Rifabutin and Proluton Depot 250 mg Injection 1 ml together can lead to an interaction; they can be taken if your doctor advises. However, if you experience any abnormal bleeding, or pain, swelling, itching, bruising, or a lump at the injection site, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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HYDROXYPROGESTERONE-250MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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HYDROXYPROGESTERONE-250MGCaffeine containing foods/drinks, Grapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu, Grapefruit Juice, Grapefruit

How to manage the interaction:
Proluton Depot 250 mg Injection 1 ml may reduce the blood levels and effects of caffeine. Grapefruit juice may increase the blood levels of Proluton Depot 250 mg Injection 1 ml. Avoid or limit taking caffeine and grape juice while taking Proluton Depot 250 mg Injection 1 ml as it can lead to interaction.

Diet & Lifestyle Advise

  • Eat a healthy and balanced diet rich in vegetables, fruits, and whole grains for reduced risk of preterm delivery.
  • Try to include heart-healthy omega 3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil.
  • Prefer more whole foods and grains instead of processed ones. Avoid the intake of processed foods, and foods high in sugar and fat.
  • Avoid stress as it can increase the chances of preterm delivery. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
  • Do regular physical activity and yoga, it keeps you fit and helps improve blood circulation and regulates oxygen supply, thereby improve the chances of carrying your baby full term.
  • Quitting smoking is the best strategy to lower the risk of premature delivery.
  • Keep your weight under control.
  • Try to avoid alcohol as it can affect your stomach and intestine and limit the absorption of the important nutrients required by your body.

Habit Forming

No

Therapeutic Class

HORMONES

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Proluton Depot 250 mg Injection 1 ml may cause dizziness, so drive only if you are alert and omit driving and operating machinery if you are feeling dizzy.

Proluton Depot 250 mg Injection 1 ml may cause weight gain. It can be due to water retention. If you feel that you are gaining a lot of weight while taking Proluton Depot 250 mg Injection 1 ml, please consult your doctor.

Proluton Depot 250 mg Injection 1 ml should be taken in the dose and duration as prescribed by the doctor.

Progesterone is an endogenous steroid and progestogen sex hormone secreted by the female reproductive part in the second half of the menstrual cycle for preparing the release of the egg in the uterus. It is also necessary for the implantation of the fertilized egg in the uterus, for maintaining pregnancy and in the hormonal replacement therapy in women deficient of progesterone.

Some of the common side effects of Proluton Depot 250 mg Injection 1 ml include nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue or throat, diarrhoea.

You should stop using Proluton Depot 250 mg Injection 1 ml and tell a doctor before using Proluton Depot 250 mg Injection 1 ml if you have uncontrolled high blood pressure (hypertension), unusual vaginal bleeding, liver disease, liver cancer, jaundice during pregnancy, circulation problems or bleeding problems, stroke, blood clot problems, breast cancer, uterus/cervix/vaginal cancer.

Drug-Drug Interactions Checker List

  • ACETAMINOPHEN
  • PRIMIDONE
  • PHENYTOIN
  • CARBAMAZEPINE
  • METFORMIN
  • GLIMEPIRIDE
  • GLIPIZIDE
  • CANAGLIFLOZIN
  • EFAVIRENZ
  • GRISEOFULVIN
  • KETOCONAZOLE
  • POSACONAZOLE

Special Advise

  • You should not be treated with Proluton Depot 250 mg Injection 1 ml if you are allergic to hydroxyprogesterone or castor oil. 
  • Proluton Depot 250 mg Injection 1 ml is not recommended for use in women less than 16 years of age. 
  • Proluton Depot 250 mg Injection 1 ml will not stop premature labor in the women in whom it has already begun.
  • Proluton Depot 250 mg Injection 1 ml is for women pregnant with only 1 child and not for use in women who are pregnant with more than one baby (twins, triplets, etc). 

Disease/Condition Glossary

Preterm labor is also called premature labor when your baby starts getting ready for birth too early in your pregnancy. It can start before 37 completed weeks of pregnancy. Premature labor can be caused by premature rupture of membranes, high blood pressure during pregnancy (pre-eclampsia), and poor diet. Symptoms of preterm labor include leaking fluid or bleeding from the vagina, feeling of pressure in the pelvis, and cramps that feel like menstrual cramps regularly. Few premature babies need special care and also have long-term mental and physical disabilities.

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