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Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
COD available

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Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Provanol Plus 5 Tablet

Provanol Plus 5 Tablet belongs to the class of 'anti-migraine drugs' primarily used to treat migraine. Migraine is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Its symptoms include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

Provanol Plus 5 Tablet consists of 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol has anxiolytic (anxiety-reducing), anti-arrhythmic (treats abnormal heart rhythms), and antihypertensive (reduces blood pressure) properties. Propranolol works by reducing cerebral (brain) blood flow by directly acting on the brain's blood vessels. It also inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation. It effectively treats and reduces the severity and frequency of migraine headaches. Flunarizine belongs to the class of calcium channel blockers. It improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. It is also used to treat vertigo (spinning sensation).

Your doctor will decide the dose and duration based on the severity of your pain. Common side effects of Provanol Plus 5 Tablet include dry weight gain, slow heart rate, tiredness, depression, drowsiness, abnormal dreams, and cold extremities (hands and feet). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Provanol Plus 5 Tablet . Provanol Plus 5 Tablet may cause weight gain in some cases, so avoid eating junk and eat a healthy, balanced diet, including home-cooked food. Consult your doctor before taking Provanol Plus 5 Tablet if you are pregnant, planning for pregnancy or breastfeeding. Avoid consuming alcohol along with Provanol Plus 5 Tablet as it could lead to increased drowsiness.

Uses of Provanol Plus 5 Tablet

Migraine.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew, crush or break it.

Medicinal Benefits

Provanol Plus 5 Tablet is used to treat migraine. It consists of 'Propranolol' and 'Flunarizine'. Propranolol is a beta-blocker and has anxiolytic (anxiety-reducing), anti-arrhythmic, and antihypertensive properties. It works by lowering cerebral (brain) blood flow and inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation. It reduces the severity and frequency of migraine headaches. Flunarizine is a channel blocker that improves blood flow and dilates blood vessels in the brain, thereby preventing headaches caused due to migraine. 

Storage

Keep Provanol Plus 5 Tablet out of sight and reach of children.
Side effects of Provanol Plus 5 Tablet
Managing Medication-Triggered Productive cough (wet cough): A Step-by-Step Guide:
  • If you experience a persistent cough after taking medication, consult your doctor to determine the best course of action.
  • Your doctor will assess and adjust your medication regimen if necessary to minimize the cough.
  • Your doctor may recommend cough medications, such as expectorants, to help loosen and clear mucus.
  • Stay hydrated by drinking plenty of fluids, and consider a soothing lifestyle, such as a warm, humid environment, avoiding irritants like smoke and dust, and getting plenty of rest.
  • If your cough persists or worsens, follow up with your doctor for further evaluation and treatment.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
  • Keep regular sleeping hours.
  • Don’t consume nicotine, caffeine, or alcohol in the hours leading up to bed.
  • Practice relaxation exercises before bedtime.
  • Regular physical activity can promote deeper and better sleep. However, avoid intense exercise within 2-3 hours of bedtime, as it can disrupt your sleep.
  • If nightmares continue, cognitive behavioral therapy (CBT) may be a helpful treatment option. Your doctor may recommend CBT to address underlying issues and provide coping strategies to manage nightmares.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Drug Warnings

Inform your doctor if you have any history of liver or kidney diseases, breathing problems (asthma, bronchitis, emphysema), diabetes, heart failure, heart rhythm problems (sinus bradycardia, Wolff-Parkinson-White syndrome, atrioventricular block), overactive thyroid, blood circulation problems (Raynaud's disease), adrenal gland tumour (pheochromocytoma), depression, metabolic acidosis (excess acid in the blood), and myasthenia gravis (muscle weakness) before starting Provanol Plus 5 Tablet . Please consult your doctor if you are pregnant and planning to conceive if the doctor advised you Provanol Plus 5 Tablet . Avoid consuming alcohol along with Provanol Plus 5 Tablet as it could lead to increased dizziness and drowsiness.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Provanol Plus 5 Tablet:
Coadministration of thioridazine with Provanol Plus 5 Tablet may increase the blood levels of thioridazine and cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Provanol Plus 5 Tablet and thioridazine, they can be taken together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, and shortness of breath contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Provanol Plus 5 Tablet:
Taking Provanol Plus 5 Tablet with Labetalol can potentially enhance the effects of orthostatic hypotension (low blood pressure that happens when standing after sitting or lying down).

How to manage the interaction:
Although taking Provanol Plus 5 Tablet together with Labetalol can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience lightheadedness or dizziness upon standing, blurred vision, weakness, fainting, or confusion. Do not discontinue any medicine without consulting a doctor.
How does the drug interact with Provanol Plus 5 Tablet:
Coadministration of Provanol Plus 5 Tablet and levosalbutamol can increase the risk of breathing problems.

How to manage the interaction:
Although there is an interaction between Provanol Plus 5 Tablet and levosalbutamol, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololBitolterol
Severe
How does the drug interact with Provanol Plus 5 Tablet:
Using Provanol Plus 5 Tablet together with bitolterol may reduce the benefits of both medications, since they have opposing effects in the body. In addition, Provanol Plus 5 Tablet can sometimes cause breathing problems.

How to manage the interaction:
Taking Provanol Plus 5 Tablet with Bitolterol together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Provanol Plus 5 Tablet:
Taking Provanol Plus 5 Tablet and disopyramide together can enhance the effects of disopyramide.

How to manage the interaction:
Although there may be an interaction, disopyramide can be taken with Provanol Plus 5 Tablet if prescribed by your doctor. However, consult your doctor if you experience dizziness, fainting, palpitations, or slow or fast heart rate, consult your doctor immediately. Do not stop using any medications without consulting your doctor.
How does the drug interact with Provanol Plus 5 Tablet:
Taking Provanol Plus 5 Tablet together with atazanavir can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Provanol Plus 5 Tablet together with Atazanavir can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, consult your doctor immediately if you experience sudden dizziness, lightheadedness, fainting, or an irregular heartbeat. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Provanol Plus 5 Tablet:
Co-administration of Clonidine and Provanol Plus 5 Tablet may lower blood pressure and slower heart rate.

How to manage the interaction:
Although there is a possible interaction between Clonidine and Provanol Plus 5 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience headaches, slow heartbeat, dizziness, or feeling like you might pass out, contact your doctor.
PropranololIsoetarine
Severe
How does the drug interact with Provanol Plus 5 Tablet:
Using Provanol Plus 5 Tablet together with isoetharine may reduce the benefits of both medications, since they have opposing effects in the body. In addition, Provanol Plus 5 Tablet can sometimes cause breathing problems.

How to manage the interaction:
Although taking Provanol Plus 5 Tablet together with Isoetarine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PropranololIndacaterol
Severe
How does the drug interact with Provanol Plus 5 Tablet:
Using Provanol Plus 5 Tablet together with indacaterol may reduce the benefits of both medications, since they have opposing effects in the body. In addition, Provanol Plus 5 Tablet can cause breathing problems.

How to manage the interaction:
Although taking Provanol Plus 5 Tablet together with Indacaterol can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Provanol Plus 5 Tablet:
Using Provanol Plus 5 Tablet and salbutamol together can reduce the effects or increase the risk of narrowing of the airways.

How to manage the interaction:
The combined use of Provanol Plus 5 Tablet and salbutamol can lead to an interaction, but they can be taken if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid chocolates, junk food, cheese, processed food, alcohol, and smoking. Instead, eat a healthy diet and do regular exercise to avoid weight gain caused due to Provanol Plus 5 Tablet .
  • Avoid loud music, extreme temperatures, bright lights, and noisy places as it can increase headache.
  • You can try increasing your mindfulness by doing yoga, meditation, mindfulness-based cognitive therapy, and stress reduction techniques.
  • Drink enough water to stay hydrated and limit or avoid alcohol and caffeine to relieve headaches.
  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
  • You can include antioxidants in your daily diet like ashwagandha, omega-3 fatty acids, green tea, and lemon balm.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Side Effects of Provanol Plus 5 Tablet

  • Weight gain
  • Slow heart rate
  • Tiredness
  • Depression
  • Drowsiness
  • Abnormal dreams
  • Cold extremities (hands and feet)

Habit Forming

No

Therapeutic Class

ANTIMIGRAINE AGENTS

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Provanol Plus 5 Tablet is a combination of two drugs: Propranolol and Flunarizine. Provanol Plus 5 Tablet treats migraine by reducing the blood flow to the brain, and inhibits cortical spreading depression, electrical activity in the brain that causes pain and inflammation.

Provanol Plus 5 Tablet may sometimes cause weight gain during its prolonged use. It is always advised to maintain a well-balanced, healthy diet and exercise regularly.

Provanol Plus 5 Tablet does not work for a sudden migraine attack. It is helpful in only preventing new episodes of migraine headaches. Please let your doctor know if you have sudden attacks to be prescribed other suitable medications.

Provanol Plus 5 Tablet is contraindicated in asthma, slow heart rate, abnormal heart rhythms, heart conditions like AV (Atrioventricular) block or sick sinus syndrome, depression, and Parkinson's disease. Please consult your doctor before starting Provanol Plus 5 Tablet if you have a medical history.

Your doctor will prescribe Provanol Plus 5 Tablet to prevent any new episodes of migraine. Please do not stop taking this medicine unless advised by your doctor since it may lead to recurrent episodes of migraine. Provanol Plus 5 Tablet also contains Propranolol, and its sudden withdrawal may cause sweating, shaking, irregular heartbeat, and worsening of underlying angina or heart attack. Hence, do not stop using Provanol Plus 5 Tablet unless advised by your doctor.

Drug-Drug Interactions Checker List

  • ALPRAZOLAM
  • QUETIAPINE
  • ARIPIPRAZOLE
  • ZOLPIDEM
  • DIPHENHYDRAMINE
  • SERTRALINE
  • DULOXETINE
  • FLUOXETINE
  • CARBAMAZEPINE
  • PHENYTOIN

Special Advise

  • Let your doctor know that you are taking Provanol Plus 5 Tablet if you are undergoing any medical tests.
  • Beta-blockers like Propranolol can mask hypoglycaemia symptoms (low blood sugar) or hyperthyroidism (high thyroid levels).
  • It is advised to inform your doctor if you have diabetes or thyroid disease before using Provanol Plus 5 Tablet .
  • Beta-blockers can also cause changes in serum lipid profiles. Patients with pre-existing hyperlipidaemia (high lipid levels) should be closely monitored if using Provanol Plus 5 Tablet .

Disease/Condition Glossary

Migraine: It is a medical condition that involves severe throbbing pain or a pulsing sensation on one side of the head. Severe and recurrent headaches are one of the characteristic symptoms of migraine. Symptoms of migraine may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound. Migraine can be triggered by various factors like foods (eggs, tomatoes, onions, dairy products, wheat, pasta, citrus fruits, nitrites found in foods, alcohol, and red wine), hormonal changes, sleep changes, stress, loud noises, and medications.

Have a query?

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Provanol Plus 5 Tablet . Alcohol intake, along with Provanol Plus 5 Tablet , may cause increased dizziness and drowsiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or planning to conceive before using Provanol Plus 5 Tablet .

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Breast Feeding

Caution

Please consult your doctor before taking Provanol Plus 5 Tablet if you are a lactating mother.

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Driving

Caution

Provanol Plus 5 Tablet may make you feel drowsy. Do not drive or operate machinery if you experience drowsiness.

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Liver

Caution

Therapy with propranolol should be administered cautiously in patients with liver disease. Please consult your doctor if you have a history of liver impairment/liver disease.

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Kidney

Caution

Plasma clearance of Propranolol in Provanol Plus 5 Tablet is reduced in patients with renal failure. Please consult your doctor if you have a history of kidney impairment/kidney disease.

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Children

Safe if prescribed

Provanol Plus 5 Tablet is safe to use for children below 12 years of age when prescribed by the doctor.

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